Synthesis, structures of cobalt/copper complexes and magnetic property of copper complex with the mixed ligands 5-nitro-1,3-benzenedicarboxylic acid and imidazole

2006 ◽  
Vol 9 (3) ◽  
pp. 300-303 ◽  
Author(s):  
Hong-Ji Chen ◽  
Jian Zhang ◽  
Wei-Ling Feng ◽  
Meng Fu
Keyword(s):  
Magnetic Property ◽  
Copper Complex ◽  
Copper Complexes ◽  
Mixed Ligands ◽  
Benzenedicarboxylic Acid ◽  
Cobalt Copper

scholarly journals Synthesis, Crystal Structure, and Properties of a New Coordination Polymer Built from N/O-Donor Mixed Ligands

Crystals ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 372
Author(s):  
Mei-An Zhu ◽  
Shuai-Shuai Han ◽  
Feng Deng ◽  
Jia-Le Li ◽  
Shui-Sheng Chen
Keyword(s):  
Coordination Polymer ◽  
Weak Interactions ◽  
Three Dimensional ◽  
Luminescent Properties ◽  
Tridentate Ligand ◽  
Supramolecular Polymer ◽  
X Ray Diffraction ◽  
X Ray ◽  
Mixed Ligands ◽  
Benzenedicarboxylic Acid

The coordination polymer, namely, [Cd(H2L)(nobda)]n (1) was prepared by the reaction of Cd(NO3)2·4H2O with 4-amino-1,2-benzenedicarboxylic acid (H2nobda) and 1,4-di(1H-imidazol-4-yl)benzene (H2L), and characterized by single-crystal X-ray diffraction, elemental analysis, infrared (IR) spectroscopy, thermogravimetric analysis, and powder X-ray diffraction (PXRD). The carboxylic acid of H2nobda ligands was completely deprotonated to be nobda2− anions, which act as tridentate ligand to connect the Cd2+ to form two-dimensional (2D) network, while the neutral H2L ligands serve as a linear didentate bridge to connect two adjacent Cd2+ ions upper and down the 2D layer. The adjacent 2D layers were further linked into the three-dimensional (3D) supramolecular polymer by the weak interactions such as hydrogen bonds and π−π stacking interactions. The ultraviolet-visible (UV-vis) absorption spectra and luminescent properties in the solid state at room temperature have been investigated.

Hexacyanidometalate molecular chemistry: di-, tri-, tetra-, penta- (cis/trans) and hepta-nuclear chromium–copper and cobalt–copper complexes

2009 ◽  
Vol 33 (6) ◽  
pp. 1301 ◽  
Author(s):  
Maria Hernandez-Molina ◽  
Jérôme Long ◽  
Lise-Marie Chamoreau ◽  
Jean-Louis Cantin ◽  
Jürgen von Bardeleben ◽  
...  
Keyword(s):  
Copper Complexes ◽  
Molecular Chemistry ◽  
Cobalt Copper

Catalytic activity of dithioic acid copper complexes in the alkyne–azide cycloaddition

2013 ◽  
Vol 91 (4) ◽  
pp. 292-299 ◽  
Author(s):  
Bayardo E. Velasco ◽  
Gustavo López-Téllez ◽  
Nelly González-Rivas ◽  
Iván García-Orozco ◽  
Erick Cuevas-Yañez
Keyword(s):  
Catalytic Activity ◽  
Copper Complex ◽  
Copper Complexes ◽  
Functional Group ◽  
High Efficiency ◽  
High Catalytic Activity ◽  
Different Temperatures ◽  
High Yields

Diverse dithioic acid copper complexes exhibit a high catalytic activity in the copper-catalyzed alkyne–azide cycloaddition using several solvents under different temperatures, showing a high efficiency with only 0.005 mmol catalyst/mmol alkyne or less. A dithioic acid copper complex derived from acetophenone was selected and used as the catalyst in the preparation of a library of 1,4-disubstituted-1,2,3-triazoles. This process occurred in high yields and good functional group tolerance.

scholarly journals A Proteomic View of Cellular Responses to Anticancer Quinoline-Copper Complexes

Proteomes ◽  
2019 ◽  
Vol 7 (2) ◽  
pp. 26 ◽  
Author(s):  
Bastien Dalzon ◽  
Joanna Bons ◽  
Hélène Diemer ◽  
Véronique Collin-Faure ◽  
Caroline Marie-Desvergne ◽  
...  
Keyword(s):  
Copper Complex ◽  
Copper Complexes ◽  
Leukemic Cell ◽  
Anticancer Activities ◽  
Proteomic Approach ◽  
Target Action ◽  
Biological Target ◽  
Ubiquitin Proteasome ◽  
Proteasome Pathway ◽  
Validation Experiments

Metal-containing drugs have long been used in anticancer therapies. The mechansims of action of platinum-based drugs are now well-understood, which cannot be said of drugs containing other metals, such as gold or copper. To gain further insights into such mechanisms, we used a classical proteomic approach based on two-dimensional elelctrophoresis to investigate the mechanisms of action of a hydroxyquinoline-copper complex, which shows promising anticancer activities, using the leukemic cell line RAW264.7 as the biological target. Pathway analysis of the modulated proteins highlighted changes in the ubiquitin/proteasome pathway, the mitochondrion, the cell adhesion-cytoskeleton pathway, and carbon metabolism or oxido-reduction. In line with these prteomic-derived hypotheses, targeted validation experiments showed that the hydroxyquinoline-copper complex induces a massive reduction in free glutathione and a strong alteration in the actin cytoskeleton, suggesting a multi-target action of the hydroxyquinoline-copper complex on cancer cells.

scholarly journals Salicylaldehyde thiosemicarbazone copper complexes: impact of hybridization with estrone on cytotoxicity, solution stability and redox activity

2020 ◽  
Vol 44 (28) ◽  
pp. 12154-12168
Author(s):  
Tatsiana V. Petrasheuskaya ◽  
Márton A. Kiss ◽  
Orsolya Dömötör ◽  
Tamás Holczbauer ◽  
Nóra V. May ◽  
...  
Keyword(s):  
Copper Complex ◽  
Copper Complexes ◽  
Redox Activity ◽  
Solution Stability

Copper complex of a novel estrone–thiosemicarbazone hybrid with significant cytotoxicity, lipophilicity and solution stability in addition to its structurally related bicyclic analogue.

scholarly journals Enantioselectivity-Evaluation of Chiral Copper(II) Complexes Coordinated by Novel Chiral Tetradentate Ligands for Free Amino Acids by Mass Spectrometry Coupled With the Isotopically Labeled Enantiomer Method

2020 ◽  
Vol 8 ◽  
Author(s):  
Takashi Nakakoji ◽  
Kaori Yoshino ◽  
Kazuki Izutsu ◽  
Hirofumi Sato ◽  
Hiroyuki Miyake ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
Amino Acid ◽  
Copper Complex ◽  
Free Amino Acids ◽  
Free Amino ◽  
Copper Complexes ◽  
Ionization Mass ◽  
Tetradentate Ligand ◽  
Tetradentate Ligands

A series of copper(II) complexes with chiral tetradentate ligands, N,N′-ethylene- bis(S-amino acid methyl amide or methyl ester) prepared from S-alanine, S-phenylalanine, S-valine or S-proline, was generated in methanol. The copper complexes provided three component complexes in the presence of a free chiral amino acid. The enantioselectivity for the amino acid was evaluated by electrospray ionization-mass spectrometry coupled with the deuterium-labeled enantiomer method and these copper complexes were found to exhibit high enantioselectivity for free amino acids having bulky side chains. This result suggests that steric interaction between the tetradentate ligand and free amino acid was a major factor in chiral recognition. The copper complex with a chiral tetradentate ligand prepared from S-proline showed opposite enantioselectivity to copper complexes consisting of tetradentate ligands prepared from other S-amino acids. The conformational difference of the tetradentate ligand in the copper complex was found to be significant for enantioselectivity.

scholarly journals Mechanism and kinetics of copper complexes binding to the influenza A M2 channel

2020 ◽  
Author(s):  
K. McGuire ◽  
P. Smit ◽  
D. H. Ess ◽  
J. T. Hill ◽  
R. G. Harrison ◽  
...  
Keyword(s):  
Copper Complex ◽  
Influenza A ◽  
Density Functional ◽  
Copper Complexes ◽  
Covalent Bond ◽  
Proton Channel ◽  
Titration Calorimetry ◽  
Slow Step ◽  
Current Block ◽  
M2 Proton Channel

AbstractCopper(II) is known to bind in the influenza virus His37 cluster in the homotetrameric M2 proton channel and block the proton current needed for uncoating. Copper complexes based on iminodiacetate also block the M2 proton channel and show reduced cytotoxicity and zebrafish-embryo toxicity. In voltage-clamp oocyte studies using the ubiquitous amantadine-insensitive M2 S31N variant, the current block showed fast and slow phases in contrast to the single phase found for amantadine block of WT M2. Here we evaluate the mechanism of block by copper adamantyl iminodiacitate (Cu(AMT-IDA)) and copper cyclooctyl iminodiacitate (Cu(CO-IDA)) complexes and address whether the complexes can covalently bind to one or more of the His37 imidazoles. The current traces were fitted to parametrized master equations. The energetics of binding and the rate constants suggest that the first step is copper-complex binding within the channel and the slow step in the current block is the covalent bond formation between copper complex and histidine. Isothermal titration calorimetry (ITC) indicates that a single imidazole binds strongly to the copper complexes. Structural optimization using density functional theory (DFT) reveals that the complexes fit inside the channel and project the Cu(II) towards the His37 cluster allowing one imidazole to form a covalent bond with the Cu(II). Electrophysiology and DFT studies also show that the complexes block the G34E amantadine-resistant mutant in spite of some crowding in the binding site by the glutamates.

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