scholarly journals Spermine-NBD as Fluorescent Probe for Studies of Polyamine Transport System in Leishmania Donovani

2018 ◽  
Author(s):  
Raphael LABRUERE ◽  
Sébastien Pomel ◽  
Elodie Jagu ◽  
Jean-Christophe Cintrat ◽  
Philippe M. Loiseau ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Transport System ◽  
Fluorescent Probes ◽  
Leishmania Donovani ◽  
Polyamine Transport System ◽  
Polyamine Transport

This study describes the synthesis of fluorescent probes as potential substrates for the polyamine transport system (PTS) of <i>Leishmania donovani</i>. A competitive radioassay was used to determine the most efficient probe. We observed that the conjugate spermine-nitrobenzofurazan (Spm-NBD) was able to compete with [<sup>3</sup>H]-spermidine in <i>L. donovani</i> at a relevant IC<sub>50</sub> of 60 µM. <p><br></p>

scholarly journals Spermine-NBD as Fluorescent Probe for Studies of Polyamine Transport System in Leishmania Donovani

2018 ◽  
Author(s):  
Raphael LABRUERE ◽  
Sébastien Pomel ◽  
Elodie Jagu ◽  
Jean-Christophe Cintrat ◽  
Philippe M. Loiseau ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Transport System ◽  
Fluorescent Probes ◽  
Leishmania Donovani ◽  
Polyamine Transport System ◽  
Polyamine Transport

This study describes the synthesis of fluorescent probes as potential substrates for the polyamine transport system (PTS) of <i>Leishmania donovani</i>. A competitive radioassay was used to determine the most efficient probe. We observed that the conjugate spermine-nitrobenzofurazan (Spm-NBD) was able to compete with [<sup>3</sup>H]-spermidine in <i>L. donovani</i> at a relevant IC<sub>50</sub> of 60 µM. <p><br></p>

scholarly journals Spermine-NBD as fluorescent probe for studies of the polyamine transport system in Leishmania donovani

2019 ◽  
Vol 29 (14) ◽  
pp. 1710-1713
Author(s):  
Elodie Jagu ◽  
Sébastien Pomel ◽  
Stéphanie Pethe ◽  
Jean-Christophe Cintrat ◽  
Philippe M. Loiseau ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Transport System ◽  
Leishmania Donovani ◽  
Polyamine Transport System ◽  
Polyamine Transport

Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system

2009 ◽  
Vol 19 (9) ◽  
pp. 2474-2477 ◽  
Author(s):  
Yves Guminski ◽  
Martial Grousseaud ◽  
Sandrine Cugnasse ◽  
Viviane Brel ◽  
Jean-Philippe Annereau ◽  
...  
Keyword(s):  
Transport System ◽  
Fluorescent Probes ◽  
Polyamine Transport System ◽  
Polyamine Transport

Polyamine transport system-targeted nanometric micelles assembled from epipodophyllotoxin-amphiphiles

2019 ◽  
Vol 55 (99) ◽  
pp. 14968-14971 ◽  
Author(s):  
Julien Alliot ◽  
Ioanna Theodorou ◽  
Frédéric Ducongé ◽  
Edmond Gravel ◽  
Eric Doris
Keyword(s):  
Transport System ◽  
Biologically Active ◽  
Drug Conjugates ◽  
Amphiphilic Drug ◽  
Polyamine Transport System ◽  
Polyamine Transport

Micelle-forming amphiphilic drug conjugates were synthesized starting from a biologically active epipodophyllotoxin derivative which was covalently inserted in between a hydrophilic targeting spermine unit, and a hydrophobic stearyl chain.

Pulmonary alveolar macrophages express a polyamine transport system

1989 ◽  
Vol 139 (3) ◽  
pp. 624-631 ◽  
Author(s):  
Nicholas A. Saunders ◽  
Kenneth F. Ilett ◽  
Rodney F. Minchin
Keyword(s):  
Transport System ◽  
Alveolar Macrophages ◽  
Polyamine Transport System ◽  
Polyamine Transport ◽  
Pulmonary Alveolar Macrophages

Paraquat is not accumulated in B16 tumor cells by the polyamine transport system

Life Sciences ◽  
1989 ◽  
Vol 45 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Rodney F. Minchin ◽  
Roger L. Martin ◽  
Kenneth F. Ilett
Keyword(s):  
Tumor Cells ◽  
Transport System ◽  
Polyamine Transport System ◽  
Polyamine Transport
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