Current conservative treatment of uterine fibroids. Ulipristal acetate and liver damage: contrived tragedy?
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Uterine fibroids are the most common pelvic tumor formation in women and the most common indication for hysterectomy. The effectiveness of long-term intermittent use of ulipristal acetate (UA) in patients with uterine myoma has been proven earlier. In May 2018, the ability of UA to cause a drug-induced liver injury (drug-induced liver injury, DILI) was disproved, and the European Commission approved a positive decision. According to the conclusion Expertise of the Pharmacovigilance Risk Assessment Committee (Pharmacovigilance Risk Assessment Committee - PRAC) the benefit/risk ratio remains favorable. Published recommendations are aimed at reducing the risk of liver damage. UA remains the 1st line of treatment for most myomas.
2022 ◽
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2010 ◽
pp. 2527-2537
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2020 ◽
Vol 33
(7)
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pp. 1551-1560
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2013 ◽
Vol 17
(6)
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pp. 343-354
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2018 ◽
Vol 12
(3)
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pp. 180-189
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2020 ◽
Vol 10
(3)
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pp. 244-248
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