scholarly journals SYNTHESIS, CHARACTERISATION, THERMAL ANALYSIS AND DNA CLEAVAGE ACTIVITY OF A NOVELZINC (II) COMPLEX OF PYRAZOLE SCHIFF BASES

2018 ◽  
Vol 5 (2) ◽  
pp. 19-23
Author(s):  
Jayanthi Eswaran
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Acid Hydrazide ◽  
Single Step ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Shiff Base ◽  
Ft Ir

A hydrazone Schiff base Zn(II) metal complex is synthesised from the Shiff base ligand Thiophene-2-carboxylic acid hydrazide and 1, 3-diphenyl-1H-pyrazole-4-carboxaldehyde reacted together in 1:1 mole ratio to obtain Schiff base ligand (HL) which was subsequently, allowed to react with Zn(CH3COO)2.2H2O. The Schiff base ligand and its Zn (II) complex prepared were characterized on the basis of elemental nalysis,thermogravimetry, UV-Visible spectroscopy, FT-IR spectroscopy and NMR spectroscopy. IR spectrum of the zinc complex shows that the ligand (HL) is coordinated to the metal ion in monoanionicbidentate fashion with the 1:2 metal to ligand stoichiometry. The thermal behaviour of thecomplex shows a single step decomposition pattern leaving the respective ZnO residue. The DNA cleavage activity of the complex ismonitored using agarose gel lectrophoresis method which indicates the potential of the complex to cleave supercoiled DNA.

scholarly journals SYNTHESIS, CHARACTERISATION, THERMAL ANALYSIS AND DNA CLEAVAGE ACTIVITY OF COPPER PYRAZOLE SCHIFF BASE

2018 ◽  
Vol 5 (1) ◽  
pp. 23-27
Author(s):  
Jayanthi E ◽  
Anusuya M
Keyword(s):  
Schiff Base ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Acid Hydrazide ◽  
Single Step ◽  
Cleavage Activity ◽  
Imine Nitrogen ◽  
Dna Cleavage Activity ◽  
Bidentate Chelate ◽  
Ft Ir

Thiophene-2-carboxylic acid hydrazide and 1, 3-diphenyl-1H-pyrazole-4-carboxaldehyde reacted together in 1:1 mole ratio to form Schiff base ligand(L) which was subsequently, reacted with CUCl2.2H2 Oformed complex of the composition (Cu(L)Cl2). The Schiff base ligand and its Cu(II) complex were characterized on the basis of elemental analysis,thermogravimetry, UV-Visible spectroscopy, FT-IR spectroscopy and NMR spectroscopy. IR spectrum of the copper complex shows that the ligand coordinated through imine nitrogen and amide oxygen atom forming a neutral bidentate chelate with the metal centre.The thermal behaviour of thecomplex shows a single step decomposition pattern leaving CuO residues.DNA cleavage activity of the complexshowed the potential of the complex to cleave supercoiled DNA.

scholarly journals Syntheses, Characterization, Antimicrobial and DNA Cleavage Activity of Cr(III) Complexes with Coumarin based Schiff Base Ligands

2021 ◽  
Vol 33 (12) ◽  
pp. 2983-2988
Author(s):  
Ramhari Meena ◽  
Anita Kumari ◽  
Naveen Sharma ◽  
Nighat Fahmi
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Biological Activities ◽  
Spectroscopic Techniques ◽  
Molecular Weight Determination ◽  
Central Metal ◽  
Schiff Base Ligands ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

A series of biologically important complexes of chromium(III) have been synthesized by the reaction of 3-formyl-4-chlorocoumarin hydrazinecarbothioamide (L1H) and 3-formyl-4-chlorocoumarin hydrazinecarboxamide (L2H) with CrCl3·6H2O in 1:1 and 1:2 molar ratio. All the complexes have been characterized by elemental analysis, molecular weight determination, melting point, conductivity measurements, electronic, IR, 1H NMR, 13C NMR and EPR spectroscopic techniques and X-ray diffraction. In vitro biological screening effects of the compounds were tested against the pathogenic bacterial and fungal species. Further, free ligands and their metal complexes have been screened for their DNA cleavage activity. A comparative study of the biological activities of the Schiff base ligands and their Cr(III) complexes indicates that the complexes exhibit higher antimicrobial and DNA cleavage activity than the free ligands. Physico-chemical studies and spectral data suggested a hexa-coordinated environment around the central metal ion.

Photocytotoxicity and DNA cleavage activity of l-arg and l-lys Schiff base oxovanadium(iv) complexes having phenanthroline bases

2010 ◽  
Vol 39 (30) ◽  
pp. 7104 ◽  
Author(s):  
Pijus K. Sasmal ◽  
Ritankar Majumdar ◽  
Rajan R. Dighe ◽  
Akhil R. Chakravarty
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Phenanthroline Bases

scholarly journals Synthesis, Characterization, Antimicrobial, DNA Cleavage and Fluorescent Activity of Metal ion(II) Coordinate with 2H-Chromene Azo novel ligand

2020 ◽  
Vol 11 (2) ◽  
pp. 1953-1960
Author(s):  
Huda Muayad Nafea ◽  
Ali Muayad Nafea Al- Kawaz
Keyword(s):  
Dna Cleavage ◽  
Metal Ion ◽  
Condensation Reaction ◽  
Free Ligand ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Uv Visible ◽  
Group 2 ◽  
Conductance Measuring ◽  
Cobalt And Nickel

A new ligand 2H-chromene containing azo group 2-(4-nitrophenyl)-N-(4-(phenyldiazenyl)-2H-chromen-4-amine (AH), were synthesized from the condensation reaction (1:2)of 2'-hydroxychalcone and p-aminoazobenzene. Co(II), Cu(II) and Ni(II) complexes of the new ligand have been synthesized and characterized using C.H.N. analysis,1HNMR spectra, FT.IR, UV/Visible, magnetic susceptible, conductance measuring, and fluorescence spectral spectroscopy; 13CNMR spectroscopy of the ligand was also studied. Spectroscopic results revealed the 2H-Chromene Azo (AH) ligand behaves as monodentate chelating via the nitrogen atom of amine groupat position 4 having 1:1 [M:L] ratio; suggested that the cobalt and nickel complexes have the tetrahedralstructure and a distorted tetrahedralgeometry for the copper complex, indicating their non-electrolyte nature. The new ligand shows a fluorescence emissioncomparingwith this fluorescence quenching was noticed in its metal complexes. The antibacterial potency of the free ligand and its chelates with metal ion(II) were screened against E.coli, K.pneumoniae, Staph.aureus andB.Subtilis;The DNA cleavage activity of the free ligand and its 2H-chromene azo metal (II) complexes was performedby the gel electrophoresis process, which giventhat thesecompounds are effectiveupon DNA cleavage .

Syntheses, structures and DNA cleavage activity of NNO-tridentate Schiff base copper complexes

Polyhedron ◽  
2012 ◽  
Vol 45 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Bao-Tsan Ko ◽  
Chia-Chih Chang ◽  
Shu-Ling Lai ◽  
Fun-Jie Lai ◽  
Chu-Chieh Lin
Keyword(s):  
Schiff Base ◽  
Dna Cleavage ◽  
Copper Complexes ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Tridentate Schiff Base

Synthesis, characterization, antimicrobial, pesticidal and DNA cleavage activity of germanium(IV) derivatives of 3-(2-methyl-2,3-dihydro-benzthiazo-2-yl)-chromen-2-one and N′-[1-2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester ligands

2011 ◽  
Vol 34 (5-6) ◽  
pp. 139-146 ◽  
Author(s):  
Latika Dawara ◽  
Nighat Fahmi ◽  
R.V. Singh
Keyword(s):  
Antimicrobial Activity ◽  
Metal Complexes ◽  
Dna Cleavage ◽  
Metal Ion ◽  
Benzyl Ester ◽  
Germanium Atom ◽  
Conventional Heating ◽  
Molar Ratio ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Abstract The new ligands 3-(2-methyl-2,3-dihydro-benzthiazo-2-yl)-chromen-2one (AcBzH) and N′-[1-2-oxo-2H-chrome-3yl-ethylidene]-hydrazinecarbodithionic acid benzyl ester (AcBDTZH) were prepared by the reaction of 3-acetyl-2H-chromen-2-one with 2-aminothiophenol and S-benzyl dithiocarbazate, respectively. The germanium(IV) complexes have been prepared by reacting Ph3GeCl and Me3GeCl in 1:1 molar ratio with these monofunctional bidentate AcBzH and AcBDTZH ligands by using microwave as well as conventional heating methods for comparison purposes. All the synthesized compounds were characterized by elemental analyses, melting point, IR, 1H-NMR 13C-NMR, mass and X-ray powder diffraction techniques. These studies showed that the ligands coordinated to the germanium atom in a monobasic bidentate manner and trigonal bipyramidal environment around the germanium atom have been established for the complexes. To evaluate the effect of metal ion upon chelation, both ligands and their complexes have been screened for their antimicrobial activity against the various pathogenic bacterial and fungal strains. The metal complexes have shown antimicrobial activity as compared to the free ligands. The pesticidal activity and DNA cleavage activity of both ligands and their metal complexes have been tested and discussed.

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