scholarly journals Clinical Analysis of Chronic Obstructive Lung Disease Complicated with Pulmonary Interstitial Fibrosis

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Han Lime
Keyword(s):  
Lung Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Interstitial Fibrosis ◽  
Chronic Obstructive Lung Disease ◽  
Clinical Analysis ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Interstitial Fibrosis

Objective: investigate the clinical characteristics of chronicobstructive lung disease complicated with pulmonary interstitialfibrosis. Method: Choose these 240 patients with chronicobstructive lung disease who were diagnosed and treated in thehospital from 2014 to 2016, and 80 patients were checked withchronic obstructive lung disease complicated with pulmonaryinterstitial fibrosis; these patients were underwent with CTexamination, lung function examination and blood gasexamination. Result: through the CT examination, it indicates thatthe patients with c chronic obstructive lung disease withpulmonary interstitial fibrosis show excessive lung permeabilityand bullae of lung, etc. It has the statistical difference comparedwith these patients with chronic obstructive lung disease (P <0.05). The difference of lung function and blood gas indicatorbetween the two groups is statistically significant, which is ofstatistical significance (P<0.05). Conclusion: The clinicalcharacteristics of chronic obstructive lung disease complicatedwith pulmonary interstitial fibrosis are excessive lung permeabilityand bullae of lung, and the lung function and blood gas indicator ofthese patients are significantly different from those patients'indicator with chronic obstructive pulmonary disease, so it can beregarded as an important way to diagnose patients.

scholarly journals Detection of exacerbactions of chronic obstructive lung disease in the ambulatory practice

2018 ◽  
Vol 22 (1) ◽  
pp. 18-22
Author(s):  
Natalia S Maliavko ◽  
Nikita O Shatyi ◽  
Elena V Alagova ◽  
Marina A Pokhaznikova ◽  
Anatoliy K Lebedev
Keyword(s):  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Family Doctor ◽  
Chronic Obstructive Lung Disease ◽  
Self Esteem ◽  
Chronic Obstructive ◽  
Management Skills ◽  
Obstructive Pulmonary Disease ◽  
Ambulatory Practice ◽  
Exacerbation Of Copd

The article presents the results of a retrospective study aimed at identifying exacerbations in outpatients with chronic obstructive pulmonary disease (COPD) during the previous 12 months. А telephone interview was conducted with 20 patients with COPD from the departments of general medical practice of three polyclinics in the Kalininsky district of St. Petersburg. The obtained data were compared with records in outpatient cards to determine the presence of registered cases of appeals to the polyclinic for exacerbation of the disease.7 patients (35%) were identified retrospectively using the questionnaire, which can be attributed to the phenotype of COPD with frequent exacerbations. Among them, five people were hospitalized in a hospital for exacerbation of COPD, and two patients had 2 or more exacerbations in an outpatient card that did not lead to hospitalization. In 5 patients (33%), among those who were not in hospital for an exacerbation of COPD for the previous 12 months, indirect signs of low self-esteem were revealed, indicating that it is necessary to raise awareness of the exacerbation of COPD and the education patients self-management skills. (For citation: Maliavko NS, Shatyi NO, Alagova EV, et al. Detection of exacerbactions of chronic obstructive lung disease in the ambulatory practice. Russian Family Doctor. 2018;22(1):18-22. doi 10.17816/RFD2018118-22).

scholarly journals Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e036045
Author(s):  
Diana Crossley ◽  
James Stockley ◽  
Charlotte E Bolton ◽  
Nicholas S Hopkinson ◽  
Ravi Mahadeva ◽  
...  
Keyword(s):  
Health Status ◽  
Lung Function ◽  
Lung Disease ◽  
Clinical Features ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

ObjectivesTo establish a database network for the study of alpha-1 antitrypsin deficiency (AATD) and compare the results to CT lung density as the most direct measure of emphysema.DesignA central electronic database was established to permit the upload of anonymised patient data from remote sites. Prospectively collected CT data were recorded onto disc, anonymised, analysed at the coordinating centre and compared with the clinical features of the disease.SettingTertiary referral centres with expertise in the management of AATD focused on academic Biomedical Research Units and Wellcome Clinical Research Facilities.ParticipantsData were collected from 187 patients over 1 year from eight UK academic sites. This included patient demographics, postbronchodilator physiology, health status and CT. Analysis was undertaken at the coordinating centre in Birmingham.ResultsPatient recruitment in the 12 months reached 94% of target (set at 200) covering the whole spectrum of the disease from those with normal lung function to very severe chronic obstructive lung disease. CT scan suitable for analysis was available from 147 (79%) of the patients. CT density, analysed as the threshold for the lowest 15% of lung voxels, showed statistically significant relationships with the objective physiological parameters of lung function as determined by spirometric Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity staging (p<0.001) and carbon monoxide gas transfer (p<0.01). Density also correlated with subjective measures of quality of life (p=0.02).ConclusionsEstablishment of the network for data collection and its transfer was highly successful facilitating future collaboration for the study of this rare disease and its management. CT densitometry correlated well with the objective clinical features of the disease supporting its role as the specific marker of the associated emphysema and its severity. Correlations with subjective measures of health, however, were generally weak indicating other factors play a role.

scholarly journals Only severe COPD is associated with being underweight: results from a population survey

2016 ◽  
Vol 2 (3) ◽  
pp. 00051-2015 ◽  
Author(s):  
Berne Eriksson ◽  
Helena Backman ◽  
Apostolos Bossios ◽  
Anders Bjerg ◽  
Linnea Hedman ◽  
...  
Keyword(s):  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Structured Interview ◽  
Airflow Limitation ◽  
Sensitivity Analyses ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Severity Grading ◽  
Severe Copd

Low body mass index (BMI) and malnutrition in chronic obstructive pulmonary disease (COPD) are associated with a poor prognosis. The prevalence of underweight, as well as overweight, in severity grades of COPD is sparsely investigated in studies of the general population and the associated patterns of risk factors are not well established. The aim of the present study was to determine the association between severity grades of airflow limitation in COPD, and both underweight and obesity when corrected for possible confounding factors.The study is based on pooled data from the OLIN (Obstructive Lung Disease in Northern Sweden) studies. Complete records with lung function, BMI and structured interview data were available from 3942 subjects (50.7% women and 49.3% men). COPD and severity grading were defined using the Global Initiative for Chronic Obstructive Lung Disease criteria. In sensitivity analyses, the lower limit of normal was used.The prevalence of underweight was 7.3% in severe COPD (grades 3 and 4) versus 2.0% in those with normal spirometry. The prevalence of obesity increased from 9.7% in grade 1, to 16.3% in grade 2 and 20.0% in severe COPD, versus 17.7% in those with normal spirometry.In adjusted analysis, of the COPD severity grades, only severe COPD was associated with underweight (OR 3.24, 95% CI 1.0004–10.5), while the COPD severity grades tended to be inversely associated with overweight.

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