Sex differences in the lung function in chronic obstructive lung disease

2020 ◽  
Vol 0 (3) ◽  
pp. 57-61
Author(s):  
A.M. Popa ◽  
A.N. Capros ◽  
M.S. Savca
Keyword(s):  
Sex Differences ◽  
Lung Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive

scholarly journals Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e036045
Author(s):  
Diana Crossley ◽  
James Stockley ◽  
Charlotte E Bolton ◽  
Nicholas S Hopkinson ◽  
Ravi Mahadeva ◽  
...  
Keyword(s):  
Health Status ◽  
Lung Function ◽  
Lung Disease ◽  
Clinical Features ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin

ObjectivesTo establish a database network for the study of alpha-1 antitrypsin deficiency (AATD) and compare the results to CT lung density as the most direct measure of emphysema.DesignA central electronic database was established to permit the upload of anonymised patient data from remote sites. Prospectively collected CT data were recorded onto disc, anonymised, analysed at the coordinating centre and compared with the clinical features of the disease.SettingTertiary referral centres with expertise in the management of AATD focused on academic Biomedical Research Units and Wellcome Clinical Research Facilities.ParticipantsData were collected from 187 patients over 1 year from eight UK academic sites. This included patient demographics, postbronchodilator physiology, health status and CT. Analysis was undertaken at the coordinating centre in Birmingham.ResultsPatient recruitment in the 12 months reached 94% of target (set at 200) covering the whole spectrum of the disease from those with normal lung function to very severe chronic obstructive lung disease. CT scan suitable for analysis was available from 147 (79%) of the patients. CT density, analysed as the threshold for the lowest 15% of lung voxels, showed statistically significant relationships with the objective physiological parameters of lung function as determined by spirometric Global Initiative for Chronic Obstructive Lung Disease (GOLD) severity staging (p<0.001) and carbon monoxide gas transfer (p<0.01). Density also correlated with subjective measures of quality of life (p=0.02).ConclusionsEstablishment of the network for data collection and its transfer was highly successful facilitating future collaboration for the study of this rare disease and its management. CT densitometry correlated well with the objective clinical features of the disease supporting its role as the specific marker of the associated emphysema and its severity. Correlations with subjective measures of health, however, were generally weak indicating other factors play a role.

scholarly journals Spatial Ventilation Inhomogeneity Determined by Electrical Impedance Tomography in Patients With Chronic Obstructive Lung Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Inéz Frerichs ◽  
Livia Lasarow ◽  
Claas Strodthoff ◽  
Barbara Vogt ◽  
Zhanqi Zhao ◽  
...  
Keyword(s):  
Lung Function ◽  
Lung Disease ◽  
Healthy Subjects ◽  
Obstructive Lung Disease ◽  
Electrical Impedance ◽  
Vital Capacity ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Impedance Tomography ◽  
Ventilation Inhomogeneity

The aim of this study was to examine whether electrical impedance tomography (EIT) could determine the presence of ventilation inhomogeneity in patients with chronic obstructive lung disease (COPD) from measurements carried out not only during conventional forced full expiration maneuvers but also from forced inspiration maneuvers and quiet tidal breathing and whether the inhomogeneity levels were comparable among the phases and higher than in healthy subjects. EIT data were acquired in 52 patients with exacerbated COPD (11 women, 41 men, 68 ± 11 years) and 14 healthy subjects (6 women, 8 men, 38 ± 8 years). Regional lung function parameters of forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), forced inspiratory vital capacity (FIVC), forced inspiratory volume in 1 s (FIV1), and tidal volume (VT) were determined in 912 image pixels. The spatial inhomogeneity of the pixel parameters was characterized by the coefficients of variation (CV) and the global inhomogeneity (GI) index. CV and GI values of pixel FVC, FEV1, FIVC, FIV1, and VT were significantly higher in patients than in healthy subjects (p ≤ 0.0001). The ventilation distribution was affected by the analyzed lung function parameter in patients (CV: p = 0.0024, GI: p = 0.006) but not in healthy subjects. Receiver operating characteristic curves showed that CV and GI discriminated patients from healthy subjects with an area under the curve (AUC) of 0.835 and 0.852 (FVC), 0.845 and 0.867 (FEV1), 0.903 and 0.903 (FIVC), 0.891 and 0.882 (FIV1), and 0.821 and 0.843 (VT), respectively. These findings confirm the ability of EIT to identify increased ventilation inhomogeneity in patients with COPD.

scholarly journals Clinical Analysis of Chronic Obstructive Lung Disease Complicated with Pulmonary Interstitial Fibrosis

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Han Lime
Keyword(s):  
Lung Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Interstitial Fibrosis ◽  
Chronic Obstructive Lung Disease ◽  
Clinical Analysis ◽  
Chronic Obstructive ◽  
Blood Gas ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Interstitial Fibrosis

Objective: investigate the clinical characteristics of chronicobstructive lung disease complicated with pulmonary interstitialfibrosis. Method: Choose these 240 patients with chronicobstructive lung disease who were diagnosed and treated in thehospital from 2014 to 2016, and 80 patients were checked withchronic obstructive lung disease complicated with pulmonaryinterstitial fibrosis; these patients were underwent with CTexamination, lung function examination and blood gasexamination. Result: through the CT examination, it indicates thatthe patients with c chronic obstructive lung disease withpulmonary interstitial fibrosis show excessive lung permeabilityand bullae of lung, etc. It has the statistical difference comparedwith these patients with chronic obstructive lung disease (P <0.05). The difference of lung function and blood gas indicatorbetween the two groups is statistically significant, which is ofstatistical significance (P<0.05). Conclusion: The clinicalcharacteristics of chronic obstructive lung disease complicatedwith pulmonary interstitial fibrosis are excessive lung permeabilityand bullae of lung, and the lung function and blood gas indicator ofthese patients are significantly different from those patients'indicator with chronic obstructive pulmonary disease, so it can beregarded as an important way to diagnose patients.

Sign in / Sign up

Export Citation Format

Share Document