Age-related changes in body weight, Body Conformation and Scrotal Circumference and Prepubertal  Sexual behavior of Kundhi Buffalo Bull Calves

We investigated age-related changes in the distribution of body weight on soles of feet in 878 healthy subjects ranging from 5 to 80 years of age. By modifying Morton's Staticometer, we constructed an instrument for measuring body-weight distribution over three areas of soles of the feet, the big toe (inner forefoot), the other four toes combined (outer forefoot) and the heels for both feet, thus a total of six areas. The weights in the six areas were recorded at the completion of nine selected actions and postures. We observed that for inhaling and exhaling standing postures, generally younger subjects had a ratio close to 1:2:3 for weights recorded for the inner toe:outer toes:heels as observed by Morton, but elderly subjects had a smaller value than 3 for the heel. The body-weight distribution tended to shift from heels to outer toes across age groups, which was more distinctly observed in women than in men.

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Age-related changes in the feedback regulation of gonadotrophin secretion in the immature and adult male rabbit

Acta Endocrinologica ◽

10.1530/acta.0.1000018 ◽

1982 ◽

Vol 100 (1) ◽

pp. 18-24 ◽

Cited By ~ 3

Author(s):

M. Berger ◽

Ch. Jean-Faucher ◽

M. De Turckheim ◽

G. Veyssière ◽

CI. Jean

Keyword(s):

Body Weight ◽

Negative Feedback ◽

Adult Male ◽

Feedback Regulation ◽

Adult Males ◽

Age Related ◽

Gonadotrophin Secretion ◽

Age Dependent ◽

Different Doses ◽

Age Related Changes

Abstract. Male rabbits were castrated at infantile (30 days), peripubertal (60 days) and adult (7–8 months) stages. Two different doses of testosterone were injected 10 days after castration (5 injections at 12 h intervals). Plasma LH and FSH were determined by RIA 1,5 and 10 days after castration and 1 h after the last injection of testosterone. The response of both gonadotrophins to castration was age-dependent. In 30 day old castrated males LH was not significantly modified and FSH had increased only 10 days after castration. In 60 day old and adult males FSH and LH levels were increased 24 h after castration and continued to rise as time progressed. For both gonadotrophins, the response of adult males to castration was higher than that of immature animals. At all stages studied, the highest dose of testosterone (250 μg/kg body weight) depressed post-castration LH and FSH levels. Twenty-five μg of testosterone per kg body weight was effective to depress LH levels only in 30 day old males, suggesting a change in the hypothalamic-pituitary unit to the negative feedback of androgens. These findings suggest that there are marked changes in the hypothalamic-pituitary unit around the beginning of the peripubertal stage. These changes could play a determinant role in the onset of puberty.

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Age-related changes in testicular parameters and their relationship to thyroid hormones and testosterone in male Murrah buffaloes

Archives Animal Breeding ◽

10.5194/aab-61-191-2018 ◽

2018 ◽

Vol 61 (2) ◽

pp. 191-195

Author(s):

Vyankat Gangadhar Jadhav ◽

Bagepalli Sathyanarayana Bharath Kumar ◽

Sujata Pandita

Keyword(s):

Correlation Coefficients ◽

Plasma Testosterone ◽

Blood Samples ◽

Murrah Buffaloes ◽

Scrotal Circumference ◽

Age Related ◽

Testicular Weight ◽

Plasma Hormone ◽

Age Related Changes ◽

Plasma Triiodothyronine

Abstract. The present study aims to investigate the age-related changes in testicular parameters and their association with plasma triiodothyronine (T3), thyroxine (T4), and testosterone in male Murrah buffaloes. Testicular measurements and single blood samples were collected from male Murrah buffaloes (n= 103) aged between 6 months and 8 years. The correlation coefficients of average testicular length (ATL), paired testis width (PTW), and scrotal circumference (SC) in relation to age were 0.88, 0.91, and 0.90, respectively. The regression equation between testicular weight (TW) and age was Y=1.48×x0.005 (r= 0.90; R2= 0.79). Plasma T4 and testosterone increased significantly (p< 0.001) with age and their levels ranged between 12.9 and 41.8 and 0.05 and 1.48 ng mL−1, respectively. With respect to associations between testicular parameters and plasma hormone levels, we observed significant (p< 0.01) correlations between ATL, PTW, SC, TW, and plasma T4. A significant correlation (r= 0.31; p< 0.01) between plasma T4 and testosterone levels was also observed. However, the correlations between plasma T3 and testicular parameters and plasma T3 and testosterone were non-significant. From the present study, we conclude that plasma T4 is positively correlated with testicular parameters and plasma testosterone, indicating its role in testis development and steroidogenesis.

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Age-related changes of malondialdehyde, body weight and organ weight in male mice

Zinc supplementation improves heme biosynthesis in rats exposed to lead ◽

10.18051/univmed.2018.v37.115-126 ◽

2018 ◽

Vol 37 (2) ◽

pp. 115

Author(s):

Ika Fidianingsih ◽

Dwi Nur Ahsani

Keyword(s):

Body Weight ◽

Free Radicals ◽

Venous Blood ◽

Relative Weight ◽

Male Mice ◽

Serum Free ◽

Organ Weights ◽

Age Related ◽

Experimental Animal Study ◽

Age Related Changes

Introduction Aging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. Methods An experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p<0.05 being considered significant. Results Significant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p>0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. Conclusion This study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.

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Age-related changes in scrotal circumference, testis size and sperm reserves in bulls of the tropically adapted Senepol breed

Animal Reproduction Science ◽

10.1016/0378-4320(93)90090-e ◽

1993 ◽

Vol 32 (3-4) ◽

pp. 185-195 ◽

Cited By ~ 5

Author(s):

S. Wildeus

Keyword(s):

Testis Size ◽

Scrotal Circumference ◽

Age Related ◽

Age Related Changes

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Age-related changes in the secretion of growth hormone in vivo and in vitro in infantile and prepubertal Holstein bull calves

Journal of Endocrinology ◽

10.1677/joe.0.1390307 ◽

1993 ◽

Vol 139 (2) ◽

pp. 307-315 ◽

Cited By ~ 9

Author(s):

J. M. McAndrews ◽

C. M. Stroud ◽

R. D. MacDonald ◽

W. C. Hymer ◽

D. R. Deaver

Keyword(s):

Pulse Amplitude ◽

Average Concentration ◽

Cell Content ◽

Baseline Concentration ◽

Age Related ◽

Bull Calves ◽

Intracellular Content ◽

Age Related Changes

ABSTRACT The average concentration of GH in blood is high at birth and declines during the period of sexual maturation in bulls. The objectives of these studies were (1) to define age-related changes in vivo in the pulsatile secretion of GH from birth to puberty, (2) to determine whether pituitary cell content of GH and characteristics of the secretion of GH in vitro reflect age-related changes in vivo, and (3) to examine whether responsiveness to GH-releasing hormone (GHRH) and somatostatin (SRIF) in vitro changed with age in Holstein bull calves. In experiment 1, calves were bled every 15 min for 12 h at <1, 12 and 42 weeks of age (n= 5/group), these being representative of infantile, juvenile and pubertal stages of development. Calves were killed 3 to 5 days later and the pars distalis of the anterior pituitary gland was enzymatically dispersed into a suspension of single cells. Aliquots of cells were extracted with 0·01 mol NaHCO3/l to determine the content of GH and cultured for 18 and 72 h. As expected, the average concentration of GH in plasma decreased with age (P<0·001). The initial decrease in GH was caused by a reduction in the baseline concentration between birth and 12 weeks of age. There was a marked decrease in GH pulse amplitude between 12 and 42 weeks of age and a further reduction in the baseline concentration. In contrast, the pulse frequency of GH increased (P<0·05) from <1 week to 12 weeks of age and remained constant thereafter. The initial intracellular content of GH and basal release of GH into media were similar at birth and 12 weeks of age. However, intracellular content of GH and basal release were decreased (P<0·01) after 18 and 72 h of culture from cells obtained from 42-week-old calves when compared with cells obtained from calves <1 and 12 weeks of age. At each age, the total amount of GH present in the cultures at 18 and 72 h was greater than intracellular GH, indicating net synthesis in culture. In experiment 2, pituitary responsiveness to GHRH and SRIF were evaluated in vitro using cells obtained from calves at <1, 12 and 25 weeks of age. GHRH stimulated and SRIF inhibited the release of GH in a dose-dependent manner. The dose required to achieve 50% of the maximum response for GHRH and SRIF was 46·9 pmol/l and 4·76 nmol/l respectively and these were not influenced by age. However, the maximum response to GHRH was greatest at 25 weeks of age and this was correlated with the initial cell content. In summary, the decrease in the average concentration of GH in plasma in bull calves was caused initially by a reduction in the baseline concentration of GH and then by a decline in GH pulse amplitude. The decrease in GH levels between birth and 12 weeks of age was not accompanied by changes in the initial GH content of the pituitary, the ability of somatotrophs to secrete GH in vitro, or changes in pituitary sensitivity to GHRH or SRIF. Thus, the changes in the secretion of hypothalamic factors may account for the initial decrease in GH. However, the low circulating level of GH at 42 weeks of age was associated with a reduced somatotroph content of GH and a decrease in the ability to secrete GH in culture, indicating a fundamental change in somatotroph function in older animals that is retained in vitro. Journal of Endocrinology (1993) 139, 307–315

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