Age-related changes of malondialdehyde, body weight and organ weight in male mice

Introduction Aging is characterized by gradual impairment in all physiological functions. Increases in free radicals and changes in organ morphology occur with aging. The purpose of this study was to determine age-related changes in serum free radicals, body weight, organ weights, and relative organ weights in male mice. Methods An experimental animal study was performed on 25 male mice (Mus musculus), which were randomized into 5 groups according to age at termination, i.e. 12 (group K1), 24 (K2), 32 (K3), 40 (K4) and 48 weeks (K5), respectively. Retro-orbital venous blood was taken for examination of malondialdehyde (MDA) levels. After termination, liver, heart, kidneys, testes, brain, thymus and spleen were weighed using an analytical balance. ANOVA and Kruskal Wallis tests were used to analyze the data, with p<0.05 being considered significant. Results Significant changes were found with age in serum MDA level (p=0.000), body weight (p=0.000), and weights of all organs except thymus (p>0.05) (liver p=0.023, heart p=0.000, kidneys p=0.002, testes p=0.000, brain p=0.012 and spleen p=0.006). Significant changes in relative weight of brain (p=0.001) and spleen (p=0.049) were also found with age. Conclusion This study demonstrated increases in serum MDA levels, body weight, and weights of the liver, heart, kidneys, testes, brain and spleen with age. Peak increases in weights of kidneys and thymus were found earlier than those in MDA levels and weights of other organs.

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CHARACTERIZATION OF AGE-RELATED CHANGES IN BODY WEIGHT AND ORGAN WEIGHTS FROM BIRTH TO ADOLESCENCE IN HUMANS

Journal of Toxicology and Environmental Health Part A ◽

10.1080/152873901753215911 ◽

2001 ◽

Vol 64 (6) ◽

pp. 453-464 ◽

Cited By ~ 76

Author(s):

Sami Haddad ◽

Concetta Restieri ◽

Kannan Krishnan

Keyword(s):

Body Weight ◽

Organ Weights ◽

Age Related ◽

Age Related Changes

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NPY Deficiency Prevents Postmenopausal Adiposity by Augmenting Estradiol-Mediated Browning

The Journals of Gerontology Series A ◽

10.1093/gerona/gly282 ◽

2018 ◽

Vol 75 (6) ◽

pp. 1042-1049

Author(s):

Seongjoon Park ◽

Erkhembayar Nayantai ◽

Toshimitsu Komatsu ◽

Hiroko Hayashi ◽

Ryoichi Mori ◽

...

Keyword(s):

Body Weight ◽

Adipose Tissue ◽

Fat Metabolism ◽

Male Mice ◽

Wild Type ◽

Male And Female ◽

Female Mice ◽

Age Related ◽

Promising Target ◽

Intracellular Mechanism

Abstract The orexigenic hormone neuropeptide Y (NPY) plays a pivotal role in the peripheral regulation of fat metabolism. However, the mechanisms underlying the effects of sex on NPY function have not been extensively analyzed. In this study, we examined the effects of NPY deficiency on fat metabolism in male and female mice. Body weight was slightly decreased, whereas white adipose tissue (WAT) mass was significantly decreased as the thermogenic program was upregulated in NPY-/- female mice compared with that in wild-type mice; these factors were not altered in response to NPY deficiency in male mice. Moreover, lack of NPY resulted in an increase in luteinizing hormone (LH) expression in the pituitary gland, with concomitant activation of the estradiol-mediated thermogenic program in inguinal WAT, and alleviated age-related modification of adiposity in female mice. Taken together, these data revealed a novel intracellular mechanism of NPY in the regulation of fat metabolism and highlighted the sexual dimorphism of NPY as a promising target for drug development to reduce postmenopausal adiposity.

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Age-Related changes in Male Rat Reproductive Organ Weights and Plasma Testosterone Concentrations After Administration of a Monoamine Oxidase Inhibitors†Supported by the Henry C. Buswell Fund for Urology Research.†Presented at the Thirty-Second Annual Meeting of The American Fertility Society, April 5 to 9, 1976, Las Vegas, Nev.

Fertility and Sterility ◽

10.1016/s0015-0282(16)42204-1 ◽

1976 ◽

Vol 27 (11) ◽

pp. 1326-1334 ◽

Cited By ~ 6

Author(s):

Ronald L. Urry ◽

Kathryn A. Dougherty ◽

Abraham T.K. Cockett

Keyword(s):

Monoamine Oxidase ◽

Annual Meeting ◽

Las Vegas ◽

Reproductive Organ ◽

Male Rat ◽

Plasma Testosterone ◽

Organ Weights ◽

Age Related ◽

American Fertility Society ◽

Age Related Changes

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Age-related changes in serum free thyroxine during childhood and adolescence

The Journal of Pediatrics ◽

10.1016/s0022-3476(05)80385-3 ◽

1993 ◽

Vol 123 (6) ◽

pp. 899-905 ◽

Cited By ~ 54

Author(s):

Jerald C. Nelson ◽

Susan J. Clark ◽

Danielle L. Borut ◽

Ray T. Tomei ◽

Esther I. Carlton

Keyword(s):

Free Thyroxine ◽

Childhood And Adolescence ◽

Serum Free ◽

Age Related ◽

Age Related Changes ◽

Serum Free Thyroxine

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Age-Related Determinants of Stress-Induced Weight Change in Mice

Psychological Reports ◽

10.2466/pr0.1975.37.1.112 ◽

1975 ◽

Vol 37 (1) ◽

pp. 112-114 ◽

Cited By ~ 2

Author(s):

Walter B. Essman ◽

Fred Kimmelstiel ◽

Barry Sporer

Keyword(s):

Weight Loss ◽

Body Weight ◽

Gas Phase ◽

Tobacco Smoke ◽

Body Weight Loss ◽

Plasma Corticosterone ◽

Male Mice ◽

Air Exposure ◽

Age Related ◽

Old Mice

25-day-old male mice showed a greater incidence of body weight loss and a late peak of plasma corticosterone elevation when exposed to tobacco smoke for 5 successive days, as compared with mice exposed to filtered smoke (gas phase) or air. 50-day-old mice had a greater incidence and magnitude of body weight loss and a late plasma corticosterone peak after 5 days of air exposure, but not with gas phase or nicotine + gas phase. Diencephalic serotonin, while higher among 25-day-old mice, did not differ as a function of the stress of confinement during exposure to the ventillatory stimulus or as a function of the different stimuli. The results suggest that weight loss and the time following stimulation at which plasma corticosterone is maximally elevated may serve as indices of stress and are consistent even when the stressor-susceptibility is age-related.

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Age-Related Changes in Distribution of Body Weight on Soles of Feet for Selected Actions and Postures

Perceptual and Motor Skills ◽

10.2466/pms.1997.85.3f.1263 ◽

1997 ◽

Vol 85 (3_suppl) ◽

pp. 1263-1271 ◽

Cited By ~ 1

Author(s):

Toshiaki Yanagida ◽

Takaaki Asami

Keyword(s):

Body Weight ◽

Weight Distribution ◽

Healthy Subjects ◽

Age Groups ◽

The Body ◽

The Other ◽

Elderly Subjects ◽

Age Related ◽

Soles Of The Feet ◽

Age Related Changes

We investigated age-related changes in the distribution of body weight on soles of feet in 878 healthy subjects ranging from 5 to 80 years of age. By modifying Morton's Staticometer, we constructed an instrument for measuring body-weight distribution over three areas of soles of the feet, the big toe (inner forefoot), the other four toes combined (outer forefoot) and the heels for both feet, thus a total of six areas. The weights in the six areas were recorded at the completion of nine selected actions and postures. We observed that for inhaling and exhaling standing postures, generally younger subjects had a ratio close to 1:2:3 for weights recorded for the inner toe:outer toes:heels as observed by Morton, but elderly subjects had a smaller value than 3 for the heel. The body-weight distribution tended to shift from heels to outer toes across age groups, which was more distinctly observed in women than in men.

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Age-related changes in the feedback regulation of gonadotrophin secretion in the immature and adult male rabbit

Acta Endocrinologica ◽

10.1530/acta.0.1000018 ◽

1982 ◽

Vol 100 (1) ◽

pp. 18-24 ◽

Cited By ~ 3

Author(s):

M. Berger ◽

Ch. Jean-Faucher ◽

M. De Turckheim ◽

G. Veyssière ◽

CI. Jean

Keyword(s):

Body Weight ◽

Negative Feedback ◽

Adult Male ◽

Feedback Regulation ◽

Adult Males ◽

Age Related ◽

Gonadotrophin Secretion ◽

Age Dependent ◽

Different Doses ◽

Age Related Changes

Abstract. Male rabbits were castrated at infantile (30 days), peripubertal (60 days) and adult (7–8 months) stages. Two different doses of testosterone were injected 10 days after castration (5 injections at 12 h intervals). Plasma LH and FSH were determined by RIA 1,5 and 10 days after castration and 1 h after the last injection of testosterone. The response of both gonadotrophins to castration was age-dependent. In 30 day old castrated males LH was not significantly modified and FSH had increased only 10 days after castration. In 60 day old and adult males FSH and LH levels were increased 24 h after castration and continued to rise as time progressed. For both gonadotrophins, the response of adult males to castration was higher than that of immature animals. At all stages studied, the highest dose of testosterone (250 μg/kg body weight) depressed post-castration LH and FSH levels. Twenty-five μg of testosterone per kg body weight was effective to depress LH levels only in 30 day old males, suggesting a change in the hypothalamic-pituitary unit to the negative feedback of androgens. These findings suggest that there are marked changes in the hypothalamic-pituitary unit around the beginning of the peripubertal stage. These changes could play a determinant role in the onset of puberty.

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