Corticotropin-releasing hormone and the blood-brain-barrier

10.2741/2174 ◽  
2007 ◽  
Vol 12 (1) ◽  
pp. 1615 ◽  
Author(s):  
Theoharis, C. Theoharides
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Blood Brain

scholarly journals Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress

2002 ◽  
Vol 303 (3) ◽  
pp. 1061-1066 ◽  
Author(s):  
Pamela Esposito ◽  
Nathan Chandler ◽  
Kristiana Kandere ◽  
Subimal Basu ◽  
Stanley Jacobson ◽  
...  
Keyword(s):  
Mast Cells ◽  
Blood Brain Barrier ◽  
Acute Stress ◽  
Brain Barrier ◽  
Corticotropin Releasing Hormone ◽  
Barrier Permeability ◽  
Releasing Hormone ◽  
Blood Brain Barrier Permeability ◽  
Blood Brain ◽  
Brain Barrier Permeability

Differential Interactions of Urocortin/Corticotropin-Releasing Hormone Peptides with the Blood-Brain Barrier

2002 ◽  
Vol 75 (6) ◽  
pp. 367-374 ◽  
Author(s):  
Abba J. Kastin ◽  
Victoria Akerstrom
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Corticotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Blood Brain

scholarly journals Corticotropin-Releasing Hormone Receptor-1 in Cerebral Microvessels Changes during Development and Influences Urocortin Transport across the Blood-Brain Barrier

Endocrinology ◽  
2009 ◽  
Vol 151 (3) ◽  
pp. 1221-1227 ◽  
Author(s):  
Hung Hsuchou ◽  
Abba J. Kastin ◽  
Xiaojun Wu ◽  
Hong Tu ◽  
Weihong Pan
Keyword(s):  
Blood Brain Barrier ◽  
Hormone Receptor ◽  
Brain Barrier ◽  
Receptor Subtypes ◽  
Multiple Time ◽  
Corticotropin Releasing Hormone ◽  
Cerebral Microvessels ◽  
Releasing Hormone ◽  
Adult Mice ◽  
Blood Brain

In this study we tested the hypothesis that receptor-mediated transport of urocortin across the blood-brain barrier (BBB) undergoes developmental changes. Urocortin is a peptide produced by both selective brain regions and peripheral organs, and it is involved in feeding, memory, mood, cardiovascular functions, and immune regulation. In BBB studies with multiple-time regression analysis, we found that neonatal mice had a significant influx of 125I-urocortin. By contrast, adult mice did not transport urocortin across the BBB. Quantitative RT-PCR showed that corticotropin-releasing hormone receptor (CRHR)-1 was developmentally regulated in enriched cerebral microvessels as well as hypothalamus, being significantly higher in neonatal than adult mice. This change was less dramatic in agouti viable yellow mice, a strain that develops adult-onset obesity. The level of expression of CRHR1 mRNA was 33-fold higher in the microvessels than in hypothalamic homogenates. The mRNA for CRHR2 was less abundant in both regions and less prone to changes with development or the agouti viable yellow mutation. Supported by previous findings of receptor-mediated endocytosis of urocortin, these results suggest that permeation of urocortin across the BBB is dependent on the level of CRHR1 expression in cerebral microvessels. These novel findings of differential regulation of CRH receptor subtypes help elucidate developmental processes in the brain, particularly for the urocortin system.

Passage through the blood-brain barrier of thyrotropin-releasing hormone encapsulated in liposomes

1980 ◽  
Vol 32 (1) ◽  
pp. 722-724 ◽  
Author(s):  
TH. J. POSTMES ◽  
M. HUKKELHOVEN ◽  
A. E. J. M. BOGAARD ◽  
S. G. HALDERS ◽  
J. COENEGRACHT
Keyword(s):  
Blood Brain Barrier ◽  
Thyrotropin Releasing Hormone ◽  
Brain Barrier ◽  
Releasing Hormone ◽  
Blood Brain

Slow Penetration of Thyrotropin-Releasing Hormone Across the Blood-Brain Barrier of an In Situ Perfused Guinea Pig Brain

1988 ◽  
Vol 51 (1) ◽  
pp. 252-257 ◽  
Author(s):  
Berislav V. Zloković ◽  
Milo N. Lipovac ◽  
David J. Begley ◽  
Hugh Davson ◽  
Ljubiša Rakić
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Thyrotropin Releasing Hormone ◽  
Brain Barrier ◽  
Releasing Hormone ◽  
Blood Brain ◽  
Pig Brain ◽  
Guinea Pig Brain

Impermeability of the Rat Blood-Brain Barrier to Exogenously Administered Gonadotropin-Releasing Hormone

1983 ◽  
Vol 36 (2) ◽  
pp. 102-104 ◽  
Author(s):  
Christian Verheugen ◽  
Larry R. Laufer ◽  
John L. DeFazio ◽  
William B. Pardridge ◽  
John K.H. Lu ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Gonadotropin Releasing Hormone ◽  
Brain Barrier ◽  
Releasing Hormone ◽  
Rat Blood ◽  
Blood Brain

scholarly journals Transport of CRH from mouse brain directly affects peripheral production of β-endorphin by the spleen

1997 ◽  
Vol 273 (6) ◽  
pp. E1083-E1089 ◽  
Author(s):  
J. Martin Martins ◽  
William A. Banks ◽  
Abba J. Kastin
Keyword(s):  
Pituitary Gland ◽  
Blood Brain Barrier ◽  
Mouse Brain ◽  
Brain Barrier ◽  
Regulatory Function ◽  
Corticotropin Releasing Hormone ◽  
Peripheral Organ ◽  
Releasing Hormone ◽  
Peripheral Production ◽  
The Brain

The blood-brain barrier (BBB) regulates the passage of substances between the brain and the periphery. It has not been shown that the secretion from the brain of a small amount of a substance can directly affect the periphery by transport across the BBB. We found that central injection of radioactively labeled corticotropin-releasing hormone (CRH) resulted in the accumulation of intact CRH in the spleen. CRH also increased splenic β-endorphin, an effect not blocked by pretreatment with dexamethasone. Inhibition of the secretion of CRH from the brain by colchicine resulted in decreased accumulation of CRH in the spleen and also decreased splenic β-endorphin. Similar findings occurred in the pituitary gland. The results show that the passage of labeled CRH from the brain can directly affect a peripheral organ, thus emphasizing the regulatory function of the BBB.

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