Intensified environmental surveillance supporting the response to wild poliovirus type 1 silent circulation in Israel, 2013

An emergency response was triggered by recovery of wild poliovirus type 1 (WPV1) of the South Asia (SOAS) lineage from sewage in southern Israel in April 2013 during routine environmental surveillance. Public health risk assessment necessitated intensification of environmental surveillance in order to facilitate countrywide monitoring of WPV1-SOAS circulation. This involved increasing sampling frequency and broadening the geographical area, for better coverage of the population at risk, as well as modifying sewage testing algorithms to accommodate a newly developed WPV1-SOAS-specific quantitative real-time RT-PCR assay for screening of RNA extracted directly from sewage concentrates, in addition to standard virus isolation. Intensified surveillance in 74 sites across Israel between 1 February and 31 August 2013 documented a sustained high viral load of WPV1-SOAS in sewage samples from six Bedouin settlements and two cities with Jewish and Arab populations in the South district. Lower viral loads and intermittent detection were documented in sampling sites representing 14 mixed communities in three of the five health districts in central and northern Israel. Environmental surveillance plays a fundamental role in routine monitoring of WPV circulation in polio-free countries. The rapid assay specific for the circulating strain facilitated implementation of intensified surveillance and informed the public health response and decision-making.

Download Full-text

Detection of Multiple Cocirculating Wild Poliovirus Type 1 Lineages Through Environmental Surveillance: Impact and Progress During 2011–2013 in Pakistan

The Journal of Infectious Diseases ◽

10.1093/infdis/jiu160 ◽

2014 ◽

Vol 210 (suppl_1) ◽

pp. S324-S332 ◽

Cited By ~ 13

Author(s):

Muhammad Masroor Alam ◽

Shahzad Shaukat ◽

Salmaan Sharif ◽

Mehar Angez ◽

Adnan Khurshid ◽

...

Keyword(s):

Environmental Surveillance ◽

Poliovirus Type ◽

Wild Poliovirus

Download Full-text

Public Health Response to Restore Polio Free Status in Malaysia

Borneo Epidemiology Journal ◽

10.51200/bej.v1i2.2743 ◽

2020 ◽

Vol 1 (2) ◽

pp. 93-95

Author(s):

Richard Avoi ◽

SYED SHARIZMAN SYED ABDUL RAHIM ◽

Pasupuleti Visweswara Rao

Keyword(s):

Public Health ◽

Environmental Samples ◽

Public Health Response ◽

Poliovirus Type ◽

Immunization Programme ◽

Health Response ◽

Polio Immunization ◽

Free Status

Malaysia started the polio immunization programme since 1972 and achieved polio-free certification in 2000. After 27 years from the last reported polio case in 1992, on 8 December 2019, the Ministry of Health Malaysia announced the return of polio into the country when the first polio case detected in Sabah involving a 3-month-old male child (Abdullah, N.H., 2019). The child confirmed to be infected with vaccine-derived poliovirus type 1 (VDPV1) which later classified as a circulating vaccine-derived poliovirus type 1 (cVDPV1). Further test confirmed that the virus is genetically linked to poliovirus (PHL-NCR-2) circulating in the southern Philippines (Alleman, M.M. et al., 2020). To date, a total of four polio cases were confirmed in Sabah of which due to vaccine-derived poliovirus type 1 (VDPV1). The vaccine-derived poliovirus type 2 (VDPV2) was also detected from environmental samples taken from various locations in Sabah.

Download Full-text

Inferring Numbers of Wild Poliovirus Excretors Using Quantitative Environmental Surveillance

Vaccines ◽

10.3390/vaccines9080870 ◽

2021 ◽

Vol 9 (8) ◽

pp. 870

Author(s):

Yuri Perepliotchikov ◽

Tomer Ziv-Baran ◽

Musa Hindiyeh ◽

Yossi Manor ◽

Danit Sofer ◽

...

Keyword(s):

Oral Polio Vaccine ◽

Turnaround Time ◽

Quantitative Detection ◽

Environmental Surveillance ◽

Wild Poliovirus ◽

Polio Vaccine ◽

Kinetic Information ◽

Using Data ◽

Number Of Individuals

Response to and monitoring of viral outbreaks can be efficiently focused when rapid, quantitative, kinetic information provides the location and the number of infected individuals. Environmental surveillance traditionally provides information on location of populations with contagious, infected individuals since infectious poliovirus is excreted whether infections are asymptomatic or symptomatic. Here, we describe development of rapid (1 week turnaround time, TAT), quantitative RT-PCR of poliovirus RNA extracted directly from concentrated environmental surveillance samples to infer the number of infected individuals excreting poliovirus. The quantitation method was validated using data from vaccination with bivalent oral polio vaccine (bOPV). The method was then applied to infer the weekly number of excreters in a large, sustained, asymptomatic outbreak of wild type 1 poliovirus in Israel (2013) in a population where >90% of the individuals received three doses of inactivated polio vaccine (IPV). Evidence-based intervention strategies were based on the short TAT for direct quantitative detection. Furthermore, a TAT shorter than the duration of poliovirus excretion allowed resampling of infected individuals. Finally, the method documented absence of infections after successful intervention of the asymptomatic outbreak. The methodologies described here can be applied to outbreaks of other excreted viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where there are (1) significant numbers of asymptomatic infections; (2) long incubation times during which infectious virus is excreted; and (3) limited resources, facilities, and manpower that restrict the number of individuals who can be tested and re-tested.

Download Full-text

Molecular epidemiology of wild poliovirus type 1 circulation in West and Central Africa, from 1997 to 1999, using genotyping with a restriction fragment length polymorphism assay

Archives of Virology ◽

10.1007/s00705-007-0001-x ◽

2007 ◽

Vol 153 (3) ◽

pp. 409-416 ◽

Cited By ~ 2

Author(s):

Ionela Gouandjika-Vasilache ◽

Cara C. Burns ◽

Nicksy Gumede ◽

Sophie Guillot ◽

Didier Ménard ◽

...

Keyword(s):

Restriction Fragment Length Polymorphism ◽

Length Polymorphism ◽

Fragment Length ◽

Fragment Length Polymorphism ◽

Central Africa ◽

Poliovirus Type ◽

Wild Poliovirus ◽

West And Central Africa ◽

Restriction Fragment Length

Download Full-text

Environmental Surveillance System To Track Wild Poliovirus Transmission

Applied and Environmental Microbiology ◽

10.1128/aem.69.5.2919-2927.2003 ◽

2003 ◽

Vol 69 (5) ◽

pp. 2919-2927 ◽

Cited By ~ 52

Author(s):

Jagadish M. Deshpande ◽

Sushmitha J. Shetty ◽

Zaeem A. Siddiqui

Keyword(s):

Environmental Samples ◽

Uttar Pradesh ◽

Immunization Coverage ◽

Paralytic Poliomyelitis ◽

Nucleotide Sequence Analysis ◽

Environmental Surveillance ◽

Poliovirus Type ◽

Wild Poliovirus ◽

Supplementary Immunization Activities ◽

Type 3

ABSTRACT Eradication of poliomyelitis from large metropolis cities in India has been difficult due to high population density and the presence of large urban slums. Three paralytic poliomyelitis cases were reported in Mumbai, India, in 1999 and 2000 in spite of high immunization coverage and good-quality supplementary immunization activities. We therefore established a systematic environmental surveillance study by weekly screening of sewage samples from three high-risk slum areas to detect the silent transmission of wild poliovirus. In 2001, from among the 137 sewage samples tested, wild poliovirus type 1 was isolated from 35 and wild poliovirus type 3 was isolated from 1. Acute flaccid paralysis (AFP) surveillance indicated one case of paralytic poliomyelitis from the city. Phylogenetic analysis with complete VP1 sequences revealed that the isolates from environmental samples belonged to four lineages of wild polioviruses recently isolated from poliomyelitis cases in Uttar Pradesh and not to those previously isolated from AFP cases in Mumbai. Wild poliovirus thus introduced caused one case of paralytic poliomyelitis. The virus was detected in environmental samples 3 months before. It was found that wild polioviruses introduced several times during the year circulated in Mumbai for a limited period before being eliminated. Environmental surveillance was found to be sensitive for the detection of wild poliovirus silent transmission. Nucleotide sequence analysis helped identify wild poliovirus reservoir areas.

Download Full-text