The Possible Protective Effect of Propolis Against Aluminum Chloride Induced Hepatic Injury in Adult Male Rats. Histological Study

Objectives: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity. Methods: This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily and amikacin (200 mg/kg, i.m.) once daily for 14 days. (4) The cilostazol (28 days)-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily for 28 days and amikacin (200 mg/kg, i.m.) once daily for 14 days. Changes in the transient evoked otoacoustic emissions (TEOAEs) in the 4 groups were interpreted statistically. Results: No reported significant differences in TEOAE levels were detected between the groups at the start of the study. In all frequency bands, TEOAEs disappeared after amikacin treatment in the amikacin-alone group and remained absent in the amikacin-cilostazol (14 days) group, while TEOAEs reappeared in the amikacin-cilostazol (28 days) group. Conclusion: Cilostazol treatment for 28 days had a protective effect against amikacin-induced ototoxicity in rats.

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Effects of aluminum chloride on normal and uremic adult male rats

Biological Trace Element Research ◽

10.1007/bf02785319 ◽

1996 ◽

Vol 54 (1) ◽

pp. 43-53 ◽

Cited By ~ 15

Author(s):

G. Cherroret ◽

D. Desor ◽

M. F. Hutin ◽

D. Burnel ◽

B. Capolaghi ◽

...

Keyword(s):

Adult Male ◽

Aluminum Chloride ◽

Male Rats

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Histological study of the effect of induced arsenic intoxication on the cardiac muscle of adult male albino rats and the possible protective effect of coenzyme Q10

The Egyptian Journal of Histology ◽

10.1097/01.ehx.0000470837.21211.29 ◽

2015 ◽

Vol 38 (3) ◽

pp. 474-483

Author(s):

Noha M. Zahran ◽

Nancy M. El Sekily

Keyword(s):

Protective Effect ◽

Cardiac Muscle ◽

Adult Male ◽

Coenzyme Q10 ◽

Histological Study ◽

Albino Rats

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The protective effect of Withania somnifera against oxidative damage caused by ethanol in the testes of adult male rats

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20151340 ◽

2015 ◽

pp. 1104-1108 ◽

Cited By ~ 1

Author(s):

Divya Bhargavan ◽

B. Deepa ◽

Harish Shetty ◽

A. Krishna

Keyword(s):

Oxidative Damage ◽

Protective Effect ◽

Adult Male ◽

Withania Somnifera ◽

Male Rats

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Protective effect of propolis against aluminum chloride-induced reproductive toxicity in male rats

GSC Advanced Research and Reviews ◽

10.30574/gscarr.2021.9.2.0273 ◽

2021 ◽

Vol 9 (2) ◽

pp. 083-088

Author(s):

Essam Eldin Abdelhady Salama ◽

Ahmed Fathalla El Fouhil ◽

Khaleel Ibrahim Alyahya ◽

Sameerah Yasain Shaheen ◽

Sanaa Ahmed Alshaarawy ◽

...

Keyword(s):

Protective Effect ◽

Aluminum Chloride ◽

Testosterone Level ◽

Reproductive Toxicity ◽

Ethanol Extract ◽

Treated Group ◽

Male Rats ◽

Serum Testosterone Level ◽

Plasma Testosterone ◽

Daily Ingestion

The aim of the present study was to investigate the toxic effects of aluminum chloride (AlCl3) on the reproductive organs, as well as, the protective effect of propolis against AlCl3-induced reproductive toxicity in male rats. Eighty adult male fertile Sprague Dawley albino rats were randomly divided into four groups of 20 each. Group 1: served as control group and received only distilled water. Group 2: received a daily ingestion of 80 mg/kg of AlCl3. Group 3: received a daily ingestion of 200 mg/kg of an ethanol extract of propolis. Group 4: received a daily ingestion of 80 mg/kg of AlCl3 in addition to 200 mg/kg of an ethanol extract of propolis. The duration of experiment was six weeks. At the end of the experiment, the testes, seminal vesicles, prostate glands and epididymides were dissected out, and weighed. Sperm characteristics were evaluated and plasma testosterone level was estimated. There were no significant changes between the control and the propolis-treated group. AlCl3-treated group showed a highly significant decrease in the index weights of testes and prostate glands, a highly significant lower sperm count, motility and viability, a highly significant increase in the number of abnormal sperms, as well as, a highly significant decrease in serum testosterone level (p < 0.001), compared to control. Rats of AlCl3+propolis-treated group showed a highly significant improvement in all previous alterations. In conclusion, propolis appeared to ameliorate AlCl3-induced reproductive toxicity in male rats.

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