scholarly journals Discoid Lupus Erythematosus of the Scalp in a Patient with Systemic Lupus Erythematosus: A Case Report with Complete Hair Regrowth

2021 ◽  
Vol 79 (2) ◽  
pp. 155-158
Author(s):  
Cleide Garbelini-Lima ◽  
Gabriela Evangelista de Almeida ◽  
Sidharta Quércia Gabdelha ◽  
Andrea Cavalcante de Souza ◽  
Mara Lúcia Gomes de Souza ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Early Diagnosis ◽  
Hair Loss ◽  
Lupus Erythematosus ◽  
Direct Immunofluorescence ◽  
Discoid Lupus Erythematosus ◽  
Systemic Lupus ◽  
Hair Regrowth ◽  
Erythematous Plaques

Scalp involvement with hair loss is common in systemic lupus erythematosus. Discoid lupus erythematosus may cause scarring alopecia, characterized by well-delimited erythematous plaques with scales, follicular hyperkeratosis and atrophy, which is considered a trichological emergency. Early diagnosis and treatment are necessary in order to prevent permanent hair loss. We describe a 44 years’ old female patient with systemic lupus erythematosus for 4 years, with multiple areas of occipitoparietal alopecia, erythematous plaques, atrophy, scales and some bloody crusts. Trichoscopy, histopathology and direct immunofluorescence led to the diagnosis of discoid lupus erythematosus. After 9 months treatment with thalidomide there was complete hair regrowth.

scholarly journals Current possibilities for early diagnosis of systemic lupus erythematosus

2018 ◽  
Vol 12 (3) ◽  
pp. 34-39 ◽  
Author(s):  
V. A. Lila ◽  
V. I. Mazurov ◽  
S. V. Lapin ◽  
A. V. Mazing ◽  
A. N. Moshnikova
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Early Diagnosis ◽  
Lupus Erythematosus ◽  
Laboratory Tests ◽  
Final Diagnosis ◽  
Direct Immunofluorescence ◽  
Systemic Lupus ◽  
Immunofluorescence Method ◽  
Dermoepidermal Junction ◽  
Biopsy Specimens

The review presents the data available in the literature on the use of the lupus band test (LBT) for systemic lupus erythematosus (SLE). LBT is a direct immunofluorescence method used to detect immunoglobulins and complement factors in the dermoepidermal junction of skin biopsy specimens. LBT may be applied as one of the diagnostic tests for early diagnosis of SLE in patients without skin manifestations and in those of incomplete SLE. Like the results of other laboratory tests, those of LBT may be taken into account when establishing a final diagnosis only in conjunction with other clinical, immunological and instrumental data.

Bullous Systemic Lupus Erythematosus Mimicking Bullous Pemphigoid: A Case Report

2021 ◽  
Vol 3 (2) ◽  
pp. 51-58
Author(s):  
Vesri Yossy ◽  
Gardenia Akhyar ◽  
Alimuddin Tofrizal
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Skin Eruption ◽  
Bullous Pemphigoid ◽  
Lupus Erythematosus ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Direct Immunofluorescence ◽  
Systemic Lupus ◽  
Autoimmune Blistering Diseases

Introduction: Bullous systemic lupus erythematosus (BSLE) is an infrequent but distinct presentation of systemic lupus erythematosus (SLE) in less than 5% of lupus cases. It is characterized by vesicobullous skin eruption in SLE that can develop either before or after SLE diagnosis has been established. Distinguish between BSLE with other autoimmune blistering diseases such as bullous pemphigoid (BP), dermatitis herpetiformis, linear IgA, etc., is very important to prevent misdiagnosis. The physician must be able to combine clinical, histological and immunofluorescence finding for the diagnosis approach. We report a case of blistering skin eruption in SLE patient. Case Report: A 19-year-old female patient complained of tense blistering on her lip, face and wrists since one month ago. She was diagnosed with SLE two weeks ago. The dermatological state showed bullae and vesicle on erythematous/ normal base, erosions, excoriation and blackish red crust on the lip, face, armpit, neck, abdomen and wrists. Histopathological examination of the lesion showed sub-epidermal bullae containing PMN leukocytes consist of abundant neutrophils, only occasional eosinophils and the presence of keratotic plugs. Direct immunofluorescence (DIF) of the skin showed linear deposition of IgG, IgA, IgM and C1q at the dermo-epidermal junction. This patient exhibited similar features to both BSLE and BP with tensed clear blisters and subepidermal cleft. BSLE differ from BP by abundant neutrophils found on histopathological examination, whereas BP has abundant eosinophils. Conclusion: Immunofluorescence examination shows linear IgG in BP, whereas linear or granular IgG in BSLE. Establishing the correct diagnosis is important to prevent misdiagnosis and mistreatment.

scholarly journals Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review

2020 ◽  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Skin Lesions ◽  
Discoid Lupus Erythematosus ◽  
Antiphospholipid Antibody ◽  
Antiphospholipid Antibody Syndrome ◽  
Systemic Lupus ◽  
Lupus Panniculitis ◽  
History Of

Lupus panniculitis occurs in 1–3% of the patients diagnosed with systemic lupus erythematosus (SLE) and 10% of the patients diagnosed with discoid lupus erythematosus (DLE). It is a disorder of autoimmune origin, manifesting as deep erythematous plaques and nodules involving the trunk, breasts, buttocks, face, and proximal extremities. It does not commonly ulcerate. This report highlights the case of a 22-year-old Asian female with a history of coeliac disease and significant family history of antiphospholipid antibody syndrome (APS) who presented with fever, malaise, weight loss, and subcutaneous non-tender nodules over the forearm, back, bilateral thighs, and feet. Laboratory investigations revealed positive antinuclear antibodies, anti-Ro/SSA antibody, and lupus anticoagulant, resulting in a diagnosis of APS. Biopsies of lesions were consistent with findings of lupus panniculitis. Every case of SLE and DLE with discrete skin lesions should be reviewed for any distinct entity such as lupus panniculitis, as it may be associated with greater risk of flares and systemic involvement. The purpose of this case report is to emphasise that early diagnosis and prompt treatment is crucial to improving the prognosis of such patients.

scholarly journals Successful treatment with hydroxychloroquine for systemic lupus erythematosus with cutaneous involvement accompanied by a xanthomatous reaction

Lupus ◽  
2019 ◽  
Vol 29 (1) ◽  
pp. 79-82
Author(s):  
K Takezawa ◽  
I Ueda-Hayakawa ◽  
F Yamazaki ◽  
N Kambe ◽  
Y Son ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Hair Loss ◽  
Lupus Erythematosus ◽  
Cutaneous Lupus Erythematosus ◽  
Inflammatory Cells ◽  
Skin Lesions ◽  
Discoid Lupus Erythematosus ◽  
Parietal Region ◽  
Systemic Lupus ◽  
Vacuolar Degeneration

Antimalarials are usually recommended for the first-line systemic treatment of cutaneous lupus erythematosus. Alopecia in patients with discoid lupus erythematosus (DLE) is sometimes a refractory condition in spite of topical therapies. We herein described a case of DLE on the scalp with a pathological change of a xanthomatous reaction, which was successfully treated with hydroxychloroquine (HCQ). A 34-year-old woman presented with hair loss to the parietal region. She had been diagnosed with systemic lupus erythematosus (SLE) four years previously. Treatment with 30 mg/day of prednisolone (PSL) had been initiated, and the dose was gradually reduced. At 10 mg/day of PSL, she had noticed her hair loss. Physical examination revealed some small erythematous lesions to the parietal region with accompanying hair loss. Pathological findings of the erythematous lesion on her head revealed thickening of the basement membrane zone, the interface dermatitis with vacuolar degeneration, and both superficial perivascular and perifollicular infiltration of inflammatory cells in the dermis. In addition, there was an infiltrate of xanthomatous cells detected in the papillary dermis, which were positive for CD68 and CD163. The patient started treatment with HCQ at a dose of 200 mg/day. The skin lesions completely resolved within five months after initiation of HCQ without increase in the dose of PSL. Xanthomatous reactions are rarely recognized in lupus erythematosus. The chronic epithelial injury in DLE could be implicated in triggering the secondary reactive process of a xanthomatous reaction. We believe that the reaction seen in our patient was a secondary change to pathological alteration due to SLE. However, as yet unrecognized factors may play a role in the development of a xanthomatous reaction in DLE.

JESSNER LYMPHOCYTIC INFILTRATE POST COVID VACCINATION

2021 ◽  
pp. 48-49
Author(s):  
Kammari Divya ◽  
Kakarla Sandhya Rani
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Hymenoptera Venom ◽  
Venom Immunotherapy ◽  
Systemic Lupus ◽  
Histopathological Correlation ◽  
Erythematous Plaques ◽  
Married Female

Jessner-Kanof lymphocytic inltrate is a rare benign chronic T cell inltrative disease characterized by multiple tumid erythematous papules,plaques and nodules predominantly on sun exposed sites like face, neck and upper back. Etiology of Jessner lymphocytic inltrate is unknown but autoimmunity, Borrelia burgdorferi infection may have a possible role. There is a case report of Jessner lymphocytic inltrate after third dose of bee venom immunotherapy in hymenoptera venom anaphylaxis. Here,we report a case of 27 year married female who presented with multiple erythematous plaques and few nodules on face ,neck and upper back after 2 days of second dose of covishield vaccine. Clinical and histopathological correlation conrmed the diagnosis of Jessner-Kanof lymphocytic inltrate. Skin biopsy revealed dense perivascular and periadnexal lymphocytic inltrates in the dermis. Dermatological manifestations with covid vaccines are few in clinical volunteers but have been increasing since mass vaccination has started. A few side effects like urticaria , erythema and edema at injection site, pityriasis rosea, covid toes, systemic lupus erythematosus,rheumatoid arthritis have been reported after covid vaccination.

scholarly journals A Rare Presentation of Toxic Epidermal Necrolysis – Like Acute Systemic Lupus Erythematosus

2018 ◽  
Vol 2 (2) ◽  
pp. 144-149
Author(s):  
Brandon T Beal ◽  
Taryn Blaha ◽  
David D Xiong ◽  
Sarah H Schneider ◽  
Steven D Billings ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Toxic Epidermal Necrolysis ◽  
Lupus Erythematosus ◽  
Stevens Johnson Syndrome ◽  
Direct Immunofluorescence ◽  
Systemic Lupus ◽  
Rare Presentation ◽  
Johnson Syndrome ◽  
Perivascular Infiltrate ◽  
Erythematous Plaques

A 25-year-old woman with a history of systemic lupus erythematosus (SLE) was transferred from an outside hospital with a worsening painful generalized rash and oral ulcerations for the prior 3 weeks due to concern for Stevens-Johnson Syndrome / toxic epidermal necrolysis (TEN). Exam revealed denuded erythematous plaques covering over 80% of the patient’s body surface area and a 4.2 x 2.6 cm ulcerated plaque of the superior hard palate. Histology demonstrated parakeratosis and compact hyperkeratosis overlying an atrophic epidermis with vacuolar interface change, prominent keratinocyte dyskeratosis, and a thickened basement membrane zone (BMZ). The superficial dermis had a mild predominantly lymphocytic perivascular infiltrate and superficial dermal mucin deposition. Direct immunofluorescence was positive for IgG (granular, BMZ), C3 (granular, BMZ), and IgA was negative. Labs were remarkable for positive ANA (1:160), ds-DNA, anti-Smith, anti-RNP, low C3/C4, with negative anti-SSA/SSB. The clinicopathological correlation was most consistent with the diagnosis of TEN-like acute systemic lupus erythematosus (TEN-like ASLE). Our patient improved with treatment for her ASLE. This case highlights a challenging clinicopathologic differential diagnosis.

Endocrine malignancies and systemic lupus erythematosus: case report

2019 ◽  
Author(s):  
Nadia Ghariani Fetoui ◽  
Rima Gammoudi ◽  
Najet Ghariani ◽  
Yosra Hasni ◽  
Racha Fekih ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Case Report ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Systemic Lupus Erythematosus Case
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