scholarly journals Statement of the PPR Panel on a framework for conducting the environmental exposure and risk assessment for transition metals when used as active substances in plant protection products (PPP)

EFSA Journal ◽  
2021 ◽  
Vol 19 (3) ◽  
Author(s):  
◽  
Antonio Hernandez‐Jerez ◽  
Paulien Adriaanse ◽  
Annette Aldrich ◽  
Philippe Berny ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Transition Metals ◽  
Environmental Exposure ◽  
Plant Protection ◽  
Plant Protection Products ◽  
Active Substances

Toxicokinetic mixture effects of co-formulants and active substances in plant protection products in vitro

2021 ◽  
Vol 350 ◽  
pp. S237
Author(s):  
M. Karaca ◽  
B. Fischer ◽  
C.T. Willenbockel ◽  
P. Marx-Stoelting ◽  
D. Bloch
Keyword(s):  
Plant Protection ◽  
Plant Protection Products ◽  
Mixture Effects ◽  
Active Substances

scholarly journals Application of the Threshold of Toxicological Concern (TTC) in Food Safety: Challenges and Opportunities

2021 ◽  
Vol 3 ◽  
Author(s):  
Rositsa Serafimova ◽  
Tamara Coja ◽  
George E. N. Kass
Keyword(s):  
Food Safety ◽  
Plant Protection ◽  
Plant Protection Products ◽  
The European Union ◽  
Use Of Data ◽  
Challenges And Opportunities ◽  
Guidance Documents ◽  
Threshold Of Toxicological Concern ◽  
Active Substances

The safety assessment of chemicals added or found in food has traditionally made use of data from in vivo studies performed on experimental animals. The nature and amount of data required to carry out a risk assessment is generally stipulated either in the different food legislations or in sectoral guidance documents. However, there are still cases where no or only limited experimental data are available or not specified by law, for example for contaminants or for some minor metabolites from active substances in plant protection products. For such cases, the Threshold of Toxicological Concern (TTC) can be applied. This review explores the use of the TTC approach in food safety in the European Union, in relation to the different food sectors, legal requirements and future opportunities.

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