scholarly journals Aurora kinases: A novel target for drug development

2011 ◽  
Vol 2 (1) ◽  
Author(s):  
Liana Dedina
Keyword(s):  
Drug Development ◽  
Aurora Kinases ◽  
Novel Target

Drug development in IBD: from novel target identification to early clinical trials

Gut ◽  
2016 ◽  
Vol 65 (8) ◽  
pp. 1233-1239 ◽  
Author(s):  
Silvio Danese ◽  
Claudio Fiocchi ◽  
Julián Panés
Keyword(s):  
Clinical Trials ◽  
Drug Development ◽  
Target Identification ◽  
Novel Target

Human pregnane X receptor: a novel target for anticancer drug development

2014 ◽  
Vol 19 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Vijay Rathod ◽  
Sumit Jain ◽  
Prajwal Nandekar ◽  
Abhay T. Sangamwar
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Pregnane X Receptor ◽  
Novel Target ◽  
Anticancer Drug Development

scholarly journals Integrative Network Analysis of Early-Stage Lung Adenocarcinoma Identifies Aurora Kinase Inhibition as Interceptor of Invasion and Progression

2021 ◽  
Author(s):  
Seungyeul Yoo ◽  
Abhilasha Sinha ◽  
Dawei Yang ◽  
Nasser Altorki ◽  
Radhika Tandon ◽  
...  
Keyword(s):  
Network Analysis ◽  
Lung Adenocarcinoma ◽  
Early Stage ◽  
Aurora Kinase ◽  
Gene Signature ◽  
Aurora Kinases ◽  
Master Regulators ◽  
Novel Target ◽  
Invasive Lung Adenocarcinoma ◽  
Integrative Network

Abstract We present a gene signature distinguishing invasive and indolent tumors among early-stage lung adenocarcinoma (esLUAD). An Invasiveness Score estimated using the gene signature was strongly associated with survival of esLUAD patients in multiple independent cohorts and with the invasiveness phenotype in lung cancer cell lines. Regulatory network analysis identified aurora kinase as one of master regulators of the gene signature and perturbation of aurora kinases in vitro and in vivo reduced tumor invasion. Our study suggests aurora kinases as a novel target for treating early-stage invasive lung adenocarcinoma.

scholarly journals Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development

Virology ◽  
2017 ◽  
Vol 507 ◽  
pp. 32-39 ◽  
Author(s):  
Nopporn Chutiwitoonchai ◽  
Takafumi Mano ◽  
Michinori Kakisaka ◽  
Hirotaka Sato ◽  
Yasumitsu Kondoh ◽  
...  
Keyword(s):  
Drug Development ◽  
Nuclear Export ◽  
Influenza A ◽  
Antiviral Drug ◽  
Nuclear Export Protein ◽  
Novel Target ◽  
Export Protein

scholarly journals The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

2013 ◽  
Vol 68 (8) ◽  
pp. 1790-1800 ◽  
Author(s):  
Andrea Schiefer ◽  
Jennifer Vollmer ◽  
Christine Lämmer ◽  
Sabine Specht ◽  
Christian Lentz ◽  
...  
Keyword(s):  
Drug Development ◽  
Novel Target

Thrombin Receptor: A Novel Target for Antiplatelet Drug Development

1997 ◽  
Vol 87 (1) ◽  
pp. 37-50 ◽  
Author(s):  
Abhijit Ray ◽  
L.G. Hegde ◽  
J.B. Gupta
Keyword(s):  
Drug Development ◽  
Antiplatelet Drug ◽  
Thrombin Receptor ◽  
Novel Target
Sign in / Sign up

Export Citation Format

Share Document