scholarly journals Diagnostic Accuracy of MR Mammography in Diagnosing Malignant Breast Lesions Taking Histopathology as Gold Standard

2019 ◽  
Vol 29 (1) ◽  
pp. 16-18
Author(s):  
Saba Fatima ◽  
◽  
Shahid Waheed ◽  
Muhammad Imran Khan
Keyword(s):  
Diagnostic Accuracy ◽  
Gold Standard ◽  
Breast Lesions ◽  
Mr Mammography ◽  
Malignant Breast

scholarly journals Diagnostic Accuracy of Magnetic Resonance Spectroscopy (MRS) in Diagnosing Malignant Breast Lesions Taking Histopathology as Gold Standard

2021 ◽  
Vol 15 (7) ◽  
pp. 1847-1849
Author(s):  
Adnan Ahmed ◽  
Jawad Ali Memon ◽  
Muhammad Sibtain Shah ◽  
Hafeez ur Rehman ◽  
Tahir Baig ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Gold Standard ◽  
Resonance Spectroscopy ◽  
Breast Lesions ◽  
Female Patients ◽  
Malignant Breast

Background and Aims: Breast cancer is the prime cause of mortality among women of both developing and developed world. Out of 34.6% of female cancer patients, malignant breast cancer being the most common cancer found in Pakistan. The current study aims to evaluate the diagnostic accuracy of magnetic resonance spectroscopy in diagnosing malignant breast lesions taking histopathology as a gold standard. Materials and Methods: This cross-sectional study was carried out on 135 female patients with suspicious palpable lesions for malignancy referred from surgical OPD of Liaquat University of Medical and Health Sciences, Jamshoro during the period from October 2020 to March 2021. Magnetic resonance spectroscopy (MRS) dynamic enhanced images taken with contrast on 1.5 Tesla MRI machines were assessed based on kinetic and morphology. Malignancy biomarker was assessed with choline peak (Cho) allowed by MRS. The Single-voxel technique was utilized in order to evaluate the diagnostic performance of MRS in breast lesions malignancy. A comparison was made between MRS and biopsy findings. Results: Out of 135 female patients, 118 (87.40%) were malignant lesions patients assessed by MRS while histopathologically proven patients were 104 (77.33%). The calculated mean age of all the malignant patients was 48.3 ± 14.5 years with a range of 40-79 years. The diagnostic parameters of MRS such as specificity, accuracy, sensitivity, negative predictive value (NPV), and positive predictive value (PPV) was 74%, 88.2%, 93%, 77.8%, and 93.1% respectively while taking histopathology as a gold standard. Conclusion: MRS must be utilized as a primary imaging technique for the diagnosis of breast lesions malignancy due to its higher specificity, sensitivity, and accuracy in breast lumps characterization. MRS was found to be specific 74%, sensitive 88.2%, and accurate 93% in malignant breast cancer diagnosis. Keywords: MRS, Malignant breast lesions, Histopathology

Diagnostic Accuracy of Sonomammography in Diagnosis of BIRADS 4 Suspicious Breast Lesions Keeping Histopathology as Gold Standard

2021 ◽  
Vol 15 (10) ◽  
pp. 2772-2775
Author(s):  
Anam Manzoor ◽  
Iqra Rafique ◽  
Sana Naseer
Keyword(s):  
Diagnostic Accuracy ◽  
Predictive Value ◽  
Gold Standard ◽  
False Negative ◽  
Military Hospital ◽  
Breast Lesions ◽  
True Negative ◽  
Cross Sectional ◽  
Standard Design ◽  
Malignant Breast

Objective: To assess the diagnostic accuracy of sonomammography in diagnosis of BIRADS ≥4 suspicious breast lesions taking histopathology as gold standard. Design of the Study: It was a descriptive cross-sectional study. Study Settings: This study was carried out at Department Of Diagnostic Radiology And Diagnostic Imaging Combined Military Hospital, Lahore from January 2017 to June 2017. Material and Methods: A total of 190 patients of age 30-70 years, presenting with palpable breast lesions with BIRAD ≥4 undergoing biopsy under local anesthesia were included. Patients with already diagnosed with breast cancer and recurrent breast lesion were excluded. Then all patients were undergone USG by using a high-resolution unit (PLM703AT) with a linear array probe centered at 7, 5 MHz, along with mammography using mamomet 3000 NOVA SIEMENS, General Electric Medical Systems, Milwaukee. Patients were labeled as positive or negative. Sonomammography findings were correlated with histopathological findings. Results of the Study: In 117 sonomammography positive patients, 107 (True Positive) had malignant breast lesions and 08 (False Positive) had benign on histopathology findings. Among, 75 sonomammography negative patients, 06 (False Negative) had malignant breast lesions on histopathology whereas 69 (True Negative) had benign lesions on histopathology. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of sonomammography in diagnosis of BIRADS ≥4 suspicious breast lesions taking histopathology as gold standard was 94.69%, 89.61%, 93.04%, 92.0% and 92.63% respectively. Conclusion: This study concluded that diagnostic accuracy of sonomammography in diagnosis of BIRADS ≥4 suspicious breast lesions is quite high. Keywords: Breast lesions, malignant, sonomammography, sensitivity.

scholarly journals Ultrasound Molecular Imaging With BR55 in Patients With Breast and Ovarian Lesions: First-in-Human Results

2017 ◽  
Vol 35 (19) ◽  
pp. 2133-2140 ◽  
Author(s):  
Jürgen K. Willmann ◽  
Lorenzo Bonomo ◽  
Antonia Carla Testa ◽  
Pierluigi Rinaldi ◽  
Guido Rindi ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Gold Standard ◽  
Breast Lesions ◽  
Clinical Grade ◽  
Human Clinical Trial ◽  
Before And After ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Ultrasound Molecular Imaging ◽  
Benign Breast Lesions

Purpose We performed a first-in-human clinical trial on ultrasound molecular imaging (USMI) in patients with breast and ovarian lesions using a clinical-grade contrast agent (kinase insert domain receptor [KDR] –targeted contrast microbubble [MBKDR]) that is targeted at the KDR, one of the key regulators of neoangiogenesis in cancer. The aim of this study was to assess whether USMI using MBKDR is safe and allows assessment of KDR expression using immunohistochemistry (IHC) as the gold standard. Methods Twenty-four women (age 48 to 79 years) with focal ovarian lesions and 21 women (age 34 to 66 years) with focal breast lesions were injected intravenously with MBKDR (0.03 to 0.08 mL/kg of body weight), and USMI of the lesions was performed starting 5 minutes after injection up to 29 minutes. Blood pressure, ECG, oxygen levels, heart rate, CBC, and metabolic panel were obtained before and after MBKDR administration. Persistent focal MBKDR binding on USMI was assessed. Patients underwent surgical resection of the target lesions, and tissues were stained for CD31 and KDR by IHC. Results USMI with MBKDR was well tolerated by all patients without safety concerns. Among the 40 patients included in the analysis, KDR expression on IHC matched well with imaging signal on USMI in 93% of breast and 85% of ovarian malignant lesions. Strong KDR-targeted USMI signal was present in 77% of malignant ovarian lesions, with no targeted signal seen in 78% of benign ovarian lesions. Similarly, strong targeted signal was seen in 93% of malignant breast lesions with no targeted signal present in 67% of benign breast lesions. Conclusion USMI with MBKDR is clinically feasible and safe, and KDR-targeted USMI signal matches well with KDR expression on IHC. This study lays the foundation for a new field of clinical USMI in cancer.

scholarly journals ASSESSMENT OF DIAGNOSTIC ACCURACY OF FINE NEEDLE ASPIRATION CYTOLOGY IN BENIGN AND MALIGNANT BREAST LESIONS

2020 ◽  
Vol 4 (3) ◽  
Author(s):  
Tanwi Singh ◽  
Kalpana Chandra
Keyword(s):  
Diagnostic Accuracy ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Large Population ◽  
Needle Aspiration ◽  
Breast Lesions ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Malignant Breast ◽  
Needle Aspiration Cytology

Increasing awareness, associated anxiety & stress among women who perceive every lump in breast as carcinoma, compels the patient to seek the medical advice. It is sometimes difficult to determine whether a suspicious lump is benign or malignant simply from clinical assessment and fine needle aspiration cytology (FNAC) is helpful in reaching definitive diagnosis. Accuracy in the diagnosis can be increased by multiple sampling of appropriate sites by ultrasonography guidance and/or mammographic localization. Breast cancer is the most common cancer in women all over India. Due to lack of awareness and almost non-existent breast screening practices, patients present with palpable breast cancers. Hence based on above findings the present study was planned for Assessment of Diagnostic Accuracy of Fine Needle Aspiration Cytology in Benign and Malignant Breast Lesions. The present study was planned in Department of Pathology, Indira Gandhi Institute of Medical Science, Patna, Bihar, India. The present study was planned from duration of march 2019 to August 2019. In the present study 50 females with breast lesion were included and evaluated in the present study. The FNAC was performed in each patient by the technique of Martin and Ellis using 21-22G needle attached to 20 ml disposable syringe and smear prepared both wet fixed in 95% ethanol and air dried. All cytology smears were stained by May Grunwald Giemsa, Papanicolaou, and hematoxylin and eosin stain. It is highly useful in screening large population as it is simple, rapid, cost effective and reliable. FNAC has few limitations and biopsy is must in cases with suspicious and atypical lumps. FNAC serves as a compliment and not a substitute to the histopathology in such cases. So, it is concluded that FNAC should be used as a routine diagnostic procedure to maximize the availability of effective health care to patients with breast lesions. Keywords: Diagnostic Accuracy, Fine Needle Aspiration, Cytology, Benign, Malignant Breast Lesions, etc.

scholarly journals Diagnostic Accuracy of Ultrasound in the Detection of Malignant Focal Solid Breast Lesions Taking Biopsy as a Gold Standard

2020 ◽  
Vol 3 (3) ◽  
Author(s):  
Lina Khaled Jallad ◽  
◽  
Syed Amir Gilani ◽  
Raham Bacha ◽  
Asif Hanif ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Gold Standard ◽  
Breast Lesions

scholarly journals Evaluation of breast lesions with Doppler ultrasound: Diagnostic accuracy of resistive index as a predictor of malignancy.

2020 ◽  
Vol 27 (04) ◽  
pp. 825-830
Author(s):  
Ishrat Parveen ◽  
Koukab Javed ◽  
Breeha Elahi ◽  
Faran Nasrullah ◽  
Rashid Mahmood ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Doppler Ultrasound ◽  
Predictive Value ◽  
Gold Standard ◽  
False Negative ◽  
Malignant Lesion ◽  
Resistive Index ◽  
Breast Lesions ◽  
Malignant Lesions ◽  
Noninvasive Characterization

Objectives: To evaluate breast lesions with doppler ultrasound and calculated the diagnostic accuracy of resistive index as a predictor of malignancy, taking histopathology as gold standard. Study Design: Cross-sectional study. Setting: Radiology Department, CMH Multan. Period: December 2015 to May 2016. Material & Methods: 150 female patients, having age between 20 – 60 years, with palpable breast lumps were admitted in the study. Doppler ultrasound of the lesion was performed with emphasis on the vascularity and resistive index was formulated. Categorization as malignant or otherwise was declared as established by doppler ultrasound. Patients then underwent biopsy followed by histopathology. Correlation of doppler ultrasound and histopathological findings was done with calculation of diagnostic accuracy of doppler ultrasound, keeping histopathology as gold standard. Results: The mean of age was 40.23 ± 5.75 years. In 81 breast doppler ultrasound positive patients, 73 (True Positive) showed malignant lesions in breast while 08 (False Positive) did not have malignancy on biopsy. Among 69 Breast Doppler Ultrasound negative patients, 06 (False Negative) demonstrated malignancy on biopsy whereas 63 (True Negative) did not have any malignant lesion. Overall specificity was 88.77%, sensitivity 92.40%, negative predictive value 91.30%, positive predictive value 90.12% and diagnostic accuracy of Doppler Ultrasound came out 90.67%. Conclusion: Angiogenesis in malignant lesions lead to formation of structurally abnormal and tortuous vessels with increased resistive index. Doppler ultrasound is a safe and effective modality which shows acceptable diagnostic accuracy for noninvasive characterization of malignant breast lesions. Therefore, it can be employed as an alternative to histopathology in patients who present with breast lesions.

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