scholarly journals CONJUNCTIVAL SQUAMOUS CELL CARCINOMA;

2008 ◽  
Vol 15 (04) ◽  
pp. 455-458
Author(s):  
MUHAMMAD MUMTAZ CHAUDHRY ◽  
SHEHRYAR ALTAF
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
The Elderly ◽  
Elderly Men ◽  
In Situ Carcinoma ◽  
Conjunctival Squamous Cell Carcinoma ◽  
Study Setting ◽  
Orbital Invasion

Objectives: To evaluate 20 patients with squamous cell carcinoma of the conjunctiva. To determine the clinical andpathological characteristics. Design Retrospective study. Setting: POF hospital & EDO eye hospital Wah.Cantt Period: From June 200 toJuly 2006. Methods: The patients presenting with squamous cell carcinoma of the conjunctiva were retrospectively evaluated. Results: Patientswere usually male (80%), elderly (75% >60 years of age), with most lesions (90%) occurring at the limbus. Two patients (10%) sufferedrecurrence of the squamous cell of the conjunctiva within 2 to 4 months of resection. Corneal invasion was noted in two patients (!0%) whilethere was intraocular and orbital invasion in two patients (10%). One patient (5%) required enucleation and one patient (5%) requiredexenteration. In situ carcinoma was noted in 18 patients (90%). Conclusions: Squamous cell carcinoma of the conjunctiva occurs in the sunexposed area of the conjuntiva at the limbus in the elderly men. Recurrence was noted in the younger patients and with larger lesions.Enucleation and exenteration is required in a small number of cases.

PP - VERSICAN EXPRESSION IN ORAL LEUKOPLAKIA, IN SITU CARCINOMA AND SQUAMOUS CELL CARCINOMA: AN IMMUNOHISTOCHEMISTRY STUDY

2017 ◽  
Vol 123 (2) ◽  
pp. e77
Author(s):  
PATRICIA ROCON BIANCHI MOLINI ◽  
SANDRA VENTORIN VON ZEIDLER ◽  
KARINE GADIOLI OLIVEIRA ◽  
FABRICIO PASSADOR-SANTOS ◽  
NEY SOARES ARAÚJO ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Leukoplakia ◽  
In Situ Carcinoma

Proton beam radiotherapy of locally advanced or recurrent conjunctival squamous cell carcinoma: experience of the CATANA Centre

2020 ◽  
pp. 1-8
Author(s):  
Roberto Milazzotto ◽  
Rocco Luca Emanuele Liardo ◽  
Giuseppe Privitera ◽  
Luigi Raffaele ◽  
Vincenzo Salamone ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Proton Beam ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Disease Free Survival ◽  
Proton Beam Radiotherapy ◽  
Conjunctival Squamous Cell Carcinoma ◽  
The Impact

Abstract Aim: Conjunctival squamous cell carcinoma (SCC) is a rare tumour of the ocular region and microscopic radical surgical is difficult. There are no single guidelines for therapeutic management and the role of radiation therapy is not clearly defined although conventionally photon or electron beams are used. Proton beam radiotherapy (PBRT) is a new option for a conservative approach and allows good sparing of the organs at risk. Materials and methods: After surgical resection, we collected 15 cases treated at our institution with PBRT. The dose delivered was between 48 and 60 Gy relative biological effectiveness (RBE), with fractions of 12–15 Gy RBE. Results: After an average period of 48 months, the patients achieved excellent disease control (overall survival and disease-free survival: 86·6%), with minimal acute and late toxicity. Findings: In this work, we present our experience on the use of PBRT technique in SCC treatment. A larger sample of patients is needed to draw conclusions about the impact of this treatment on disease recurrence and overall survival.

scholarly journals De-Escalation of Therapy for Patients with Early-Stage Squamous Cell Carcinoma of the Anus

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2099
Author(s):  
Eric Miller ◽  
Jose Bazan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Early Stage ◽  
Intensity Modulated Radiation Therapy ◽  
Late Toxicity ◽  
Standard Of Care ◽  
The Elderly ◽  
Current Standard

The incidence of squamous cell carcinoma of the anus (SCCA) is increasing, particularly in the elderly, with increased mortality in this age group. While the current standard of care for localized SCCA remains chemoradiation (CRT), completion of this treatment can be challenging with risks for severe acute and late toxicity. It remains unclear if full course CRT is required for the management of early-stage SCCA or if de-escalation of treatment is possible without compromising patient outcomes. Alternative therapies include radiation therapy alone or local excision for appropriate patients. Modifying standard CRT may also reduce toxicity including the routine use of intensity-modulated radiation therapy for treatment delivery, modification of treatment volumes, and selection and dosing of concurrent systemic therapy agents. Finally, we provide an overview of currently accruing prospective trials focused on defining the role of de-escalation of therapy in patients with early-stage SCCA.

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