PENILE CANCER

Carcinoma of the penis has a well documented metastatic pattern, regional lymph nodes being the predominant site ofinvolvement. Distant metastasis is extremely rare, with a reported incidence of 1-10%. Skin metastasis is even rarer and three cases ofmetastasis to the skin have been reported previously worldwide. We present a case of carcinoma of the penis metastasizing to the skin of trunk.

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Safety and Benefit Of Sentinel Lymph Nodes Biopsy Compared to Regional Lymph Node Dissection in Primary Vulvar Cancer Patients Without Distant Metastasis and Adjacent Organ Invasion: A Retrospective Population Study

Frontiers in Oncology ◽

10.3389/fonc.2021.676038 ◽

2021 ◽

Vol 11 ◽

Author(s):

Weili Zhou ◽

Yang Bai ◽

Yangyang Yue

Keyword(s):

Lymph Node ◽

Lymph Nodes ◽

Distant Metastasis ◽

Regional Lymph Node ◽

Invasion Depth ◽

Regional Lymph Nodes ◽

Adjacent Organ ◽

Regional Lymph Node Dissection ◽

Adjacent Organ Invasion ◽

Organ Invasion

BackgroundThe safety and benefit of sentinel lymph node biopsy (SLNB) compared with regional lymph node dissection (RLND) and no lymph nodes removed (NA) in patients with vulvar squamous cell cancer (VSCC) was not well studied.MethodsA retrospective analysis on VSCC patients without distant metastasis and adjacent organ invasion from the Surveillance, Epidemiology, and End Results Program database between 2004 and 2016 was carried out. Within subgroups stratified by negative (LN−) or positive (LN+) regional lymph node findings, inverse probability weighting (IPW) adjusted multivariate Fine-Gray compete risk (CR) model and accelerated failure time (AFT) model was used to investigate the factors associated with and cancer-specific survival (CSS) and overall survival (OS).ResultsOf the 3,161 VSCC patients treated with surgery, 287 (9.1%) underwent SLNB, 1,716 (54.3%) underwent RLND, and 1,158 (36.6%) had no regional lymph nodes removed. As illustrated by IPW adjusted multivariate regressions, SLNB was significantly associated with prolonged CSS (LN−, adjusted sub-proportional hazard ratio [sHR] = 0.42; 95% confidence interval [CI], 0.19–0.93; P=0.032; LN+, adjusted sHR = 0.29; 95% CI, 0.16–0.54, P<0.001) and OS (LN−, adjusted time ratio [TR] = 1.38; 95% CI, 0.82–2.32; P=0.226; LN+, adjusted TR = 2.68; 95% CI, 1.73–4.14; P<0.001), although the effect of SLNB on OS was not significant within the LN− cohort. Moreover, SLNB led to improved CSS (adjusted sHR = 0.40; 95% CI, 0.23–0.70; P = 0.001) and OS (adjusted TR=1.15, 95% CI 0.76-1.73, P=0.279) compared with NA. Age was a significant prognostic factor of CSS and OS, whereas tumor size, surgery type, and invasion depth were not.ConclusionsSLNB leads to significantly prolonged CSS and OS in VSCC surgery patients without distant metastasis and adjacent organ invasion than RLND, except for the similar OS in the LN− cohort. SLNB could be carried out preferentially for VSCC surgery patients without distant metastasis and adjacent organ invasion, irrespective of tumor size, surgery type, invasion depth, and regional lymph nodes metastasis. Further prospective clinical trials are warranted to confirm the findings of this study.

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Penile Cancer Clinical Regional Lymph Nodes TNM Finding v7

10.32388/w6izvf ◽

2020 ◽

Author(s):

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Regional Lymph Nodes

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Penile Cancer Pathologic Regional Lymph Nodes TNM Finding v7

10.32388/mxw3qd ◽

2020 ◽

Author(s):

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Regional Lymph Nodes

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First description of basaloid carcinoma of the canine mammary gland: case report

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-10372 ◽

2019 ◽

Vol 71 (3) ◽

pp. 878-882

Author(s):

K.Y.R. Nakagaki ◽

A.B.B. Gonçalves ◽

R.M. Rocha ◽

G.D. Cassali

Keyword(s):

Mammary Gland ◽

Case Report ◽

Lymph Nodes ◽

Distant Metastasis ◽

Regional Lymph Nodes ◽

Basaloid Carcinoma ◽

Microscopic Evaluation ◽

Peripheral Cells ◽

Canine Mammary Gland ◽

Cytokeratin 14

ABSTRACT The objective of this case report was to describe histopathological and immunohistochemical characteristics of the first reported basaloid carcinomas in the canine mammary gland. Two bitches were treated for tumors in the mammary gland and underwent mastectomy. Microscopic evaluation of these tumors revealed epithelial cells arranged in a predominantly solid pattern with hyperchromatic peripheral cells arranged in a palisade pattern. Metastases in regional lymph nodes were found in both animals, and one bitch exhibited pulmonary metastasis. Immunohistochemistry revealed positive labeling for the basal cell markers cytokeratin 14 and p63. Histopathological and immunohistochemical findings led to diagnoses of basaloid carcinoma of the canine mammary gland with regional and distant metastasis.

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ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT

Siberian Journal of Oncology ◽

10.21294/1814-4861-2021-20-4-160-165 ◽

2021 ◽

Vol 20 (4) ◽

pp. 160-165

Author(s):

Z. V. Grigoryevskaya ◽

V. B. Matveev ◽

D. A. Sergeev ◽

I. V. Tereshchenko ◽

V. D. Vinnikova ◽

...

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Clinical Effect ◽

Infection Process ◽

Regional Lymph Nodes ◽

Left Groin ◽

Inguinal Lymphadenectomy ◽

Ulcerative Lesions ◽

Inflammatory Changes ◽

Infected Tumor

Introduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional lymph nodes, etc. During hospitalization nosocomial pathogens may be possible causes of infection in ulcerative lesions.The aim of the study was to present the results of the treatment of tumor ulcer in a patient with penile cancer infected with multiresistant acinetobacter baumannii and klebsiella pneumoniae.Material and methods. We present a clinical observation of 54-year-old patient diagnosed with penile cancer pt4n3m0, with ulceration of the tumor, localized at the root of the penis and ulceration of metastatic lymph nodes in the left inguinal region and subsequent infection with highly resistant nosocomial microorganisms.Results. The patient received 6 courses of paclitaxel, ifosfamide and cisplatin with clinical effect, such as significant reduction of the tumor and therapeutic pathomorphosis of 3-rd degree. Then ileo-inguinal lymphadenectomy was performed on the left. A few months later the tumor continued to grow in the left groin area. During the 2nd line of chemotherapy (cisplatin, docetaxel and capecitabine), the patient had grade iii–iv neutropenia, febrile neutropenia. High fever and localized infection in the area of tumor ulceration with multiresistant hospital microorganisms was detected. Combined antibiotic therapy had temporary effect. After isolation of multiresistant carbapenemresistant k. Pneumoniae from the ulcer, the patient was prescribed ceftazidim/avibactam 2.5 g 3 times a day. Clinical effect, such as defervescence and significant reduction of the ulceration zone was seen subsequently.Conclusion. Etiotropic antibacterial therapy of the infected tumor ulcer resulted in a significant reduction in the manifestation of the infection process, allowing antitumor therapy to be continued, as well as surgery to be performed.

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