ANTIMICROBIAL THERAPY DURING CANCER TREATMENT: A CASE REPORT

Introduction. Penile cancer (pc) is a rare cancer. The standardized incidence rate of pc in russia is 0.82 cases per 100,000 males. On average, 58 % of patients (20–96 %) with pc have a local infection process: tumor decay, the presence of erosion, tumor ulceration, inflammatory changes in regional lymph nodes, etc. During hospitalization nosocomial pathogens may be possible causes of infection in ulcerative lesions.The aim of the study was to present the results of the treatment of tumor ulcer in a patient with penile cancer infected with multiresistant acinetobacter baumannii and klebsiella pneumoniae.Material and methods. We present a clinical observation of 54-year-old patient diagnosed with penile cancer pt4n3m0, with ulceration of the tumor, localized at the root of the penis and ulceration of metastatic lymph nodes in the left inguinal region and subsequent infection with highly resistant nosocomial microorganisms.Results. The patient received 6 courses of paclitaxel, ifosfamide and cisplatin with clinical effect, such as significant reduction of the tumor and therapeutic pathomorphosis of 3-rd degree. Then ileo-inguinal lymphadenectomy was performed on the left. A few months later the tumor continued to grow in the left groin area. During the 2nd line of chemotherapy (cisplatin, docetaxel and capecitabine), the patient had grade iii–iv neutropenia, febrile neutropenia. High fever and localized infection in the area of tumor ulceration with multiresistant hospital microorganisms was detected. Combined antibiotic therapy had temporary effect. After isolation of multiresistant carbapenemresistant k. Pneumoniae from the ulcer, the patient was prescribed ceftazidim/avibactam 2.5 g 3 times a day. Clinical effect, such as defervescence and significant reduction of the ulceration zone was seen subsequently.Conclusion. Etiotropic antibacterial therapy of the infected tumor ulcer resulted in a significant reduction in the manifestation of the infection process, allowing antitumor therapy to be continued, as well as surgery to be performed.

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Penile Cancer Clinical Regional Lymph Nodes TNM Finding v7

10.32388/w6izvf ◽

2020 ◽

Author(s):

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Regional Lymph Nodes

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Anatomic Aspects of Inguinal Lymph Nodes Applied to Lymphadenectomy in Penile Cancer

Advances in Urology ◽

10.1155/2011/952532 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 7

Author(s):

João Paulo Martins de Carvalho ◽

Bruno F. Patrício ◽

Jorge Medeiros ◽

Francisco J. B. Sampaio ◽

Luciano A. Favorito

Keyword(s):

Statistical Analysis ◽

Lymph Nodes ◽

Analysis Of Variance ◽

Penile Cancer ◽

Statistical Significance ◽

Anatomical Location ◽

Anatomical Landmarks ◽

Inguinal Lymph Nodes ◽

Inguinal Lymphadenectomy ◽

Node Distribution

Objectives. To provide a better understanding of the distribution of inguinal nodes in order to prevent the complications of unnecessary and extended dissections in penile cancer.Methods. The bilateral inguinal regions of 19 male cadavers were dissected. Nodal distribution was noted and quantified based on anatomical location. The superficial nodes were subdivided into quarters as follows: superomedial, superolateral, inferomedial, and inferolateral. Statistical analysis was performed comparing node distribution between quarters using one-way analysis of variance (ANOVA), and the unpairedT-test was used between superficial and deep nodes.Results. Superficial nodes were found in all inguinal regions studied (mean = 13.60), and their distribution was more prominent in the superomedial quarter (mean = 3.94) and less in the inferolateral quarter (mean = 2.73). There was statistical significance between quarters when comparing the upper group with the lower one (P=0.02). Nodes were widely distributed in the superficial region compared with deep lymph nodes (mean = 13.60 versus 1.71,P<0.001).Conclusions. A great number of inguinal lymph nodes are distributed near the classical anatomical landmarks for inguinal lymphadenectomy, more prominent in upper quadrants.

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Low pressure video endoscopic inguinal lymphadenectomy in the treatment of penile cancer: a historical control study

10.21203/rs.3.rs-71543/v1 ◽

2020 ◽

Author(s):

Peng Xian ◽

Gangjun Yuan ◽

Junyong Dai ◽

Xianli Tang ◽

Fang Yuan ◽

...

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Ph Value ◽

Operation Time ◽

Blood Gas Analysis ◽

Gas Analysis ◽

Blood Gas ◽

Inguinal Lymphadenectomy ◽

Group 2 ◽

Control Study

Abstract Background and ObjectiveTo decrease the risk of complications of inguinal lymphadenectomy by investigating the value of low CO2 pressure video endoscopic inguinal lymphadenectomy in the treatment of penile cancer.MethodsThe clinical data of a total of 44 patients who underwent video endoscopic inguinal lymphadenectomy (VEIL) were collected for statistical analysis.ResultsThe average operation time was ( 106.88 ± 17.93) min in low CO2 pressure (LP) group and ( 115.79 ± 20.29) min in normal CO2 pressure (NP) group. The average number of lymph nodes was (10.83 ± 2.14) in LP group and (11.16 ± 1.77) ml in NP group. The intraoperative PaCO2 value was (45.51 ± 4.57) mmHg in LP group and (50.77 ± 6.50) ml in NP group. The PH value of blood gas analysis was (7.35 ± 0.05) in LP group and (7.31 ± 0.04) ml in NP group. The incidence of emphysema was 2/25 in LP group while it was 9/19 in NP group. 2 cases of skin metastasis and 1 lung metastasis were observed in NP group, but not in LP group.ConclusionsDecrease of CO2 pressure during operation will not increase the difficulty of the surgery. LP VEIL can reduce the risk of complications including hypercapnia and the subcutaneous or lung recurrence.

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PENILE CANCER

The Professional Medical Journal ◽

10.29309/tpmj/2009.16.04.2753 ◽

2009 ◽

Vol 16 (04) ◽

pp. 606-608

Author(s):

MUTAHIR ALI TUNIO ◽

MANSOOR RAFI ◽

ALTAF HUSSAIN HASHMI

Keyword(s):

Lymph Nodes ◽

Distant Metastasis ◽

Penile Cancer ◽

Skin Metastasis ◽

Regional Lymph Nodes ◽

Metastatic Pattern

Carcinoma of the penis has a well documented metastatic pattern, regional lymph nodes being the predominant site ofinvolvement. Distant metastasis is extremely rare, with a reported incidence of 1-10%. Skin metastasis is even rarer and three cases ofmetastasis to the skin have been reported previously worldwide. We present a case of carcinoma of the penis metastasizing to the skin of trunk.

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Penile Cancer Pathologic Regional Lymph Nodes TNM Finding v7

10.32388/mxw3qd ◽

2020 ◽

Author(s):

Keyword(s):

Lymph Nodes ◽

Penile Cancer ◽

Regional Lymph Nodes

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Clinical Effect of the Preservasion of Cardiac Branch of the Right Vagal Nerve on the Post-Operative Condition after the Resection of Esophageal Cancer with 3-Regional Lymph Nodes Dissection

The Japanese Journal of Gastroenterological Surgery ◽

10.5833/jjgs.25.2446 ◽

1992 ◽

Vol 25 (9) ◽

pp. 2446-2446 ◽

Cited By ~ 2

Author(s):

Yoshiaki Kajiyama ◽

Masahiko Tsurumaru ◽

Yoshimasa Ono ◽

Harushi Udagawa ◽

Goro Watanabe ◽

...

Keyword(s):

Esophageal Cancer ◽

Lymph Nodes ◽

Clinical Effect ◽

Vagal Nerve ◽

Regional Lymph Nodes ◽

Lymph Nodes Dissection ◽

The Right

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Utility of Minimally Invasive Technology for Inguinal Lymph Node Dissection in Penile Cancer

Journal of Clinical Medicine ◽

10.3390/jcm9082501 ◽

2020 ◽

Vol 9 (8) ◽

pp. 2501

Author(s):

Reza Nabavizadeh ◽

Benjamin Petrinec ◽

Andrea Necchi ◽

Igor Tsaur ◽

Maarten Albersen ◽

...

Keyword(s):

Lymph Node ◽

Minimally Invasive ◽

Lymph Nodes ◽

Lymph Node Dissection ◽

Penile Cancer ◽

Inguinal Lymph Node ◽

Node Dissection ◽

Inguinal Lymph Node Dissection ◽

Inguinal Lymphadenectomy ◽

Operative Complications

Our aim is to review the benefits as well as techniques, surgical outcomes, and complications of minimally invasive inguinal lymph node dissection (ILND) for penile cancer. The PubMed, Wiley Online Library, and Science Direct databases were reviewed in March 2020 for relevant studies limited to those published in English and within 2000–2020. Thirty-one articles describing minimally invasive ILND were identified for review. ILND has an important role in both staging and treatment of penile cancer. Minimally invasive technologies have been utilized to perform ILND in penile cancer patients with non-palpable inguinal lymph nodes and intermediate to high-risk primary tumors or patients with unilateral palpable non-fixed inguinal lymph nodes measuring less than 4 cm, including videoscopic endoscopic inguinal lymphadenectomy (VEIL) and robotic videoscopic endoscopic inguinal lymphadenectomy (RVEIL). Current data suggest that VEIL and RVEIL are feasible and safe with minimal intra-operative complications. Perhaps the strongest appeal for the use of minimally-invasive approaches is their faster post-operative recovery and less post-operative complications. As a result, patients can tolerate this procedure better and surgeons can offer surgery to patients who otherwise would not be a candidate or personally willing to undergo surgery. When compared to open technique, VEIL and RVEIL have similar dissected nodal count, a surrogate metric for oncological adequacy, and a none-inferior inguinal recurrence rate. Larger randomized studies are encouraged to investigate long-term outcome and survival rates using these minimally-invasive techniques for ILND.

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