scholarly journals A case of hepatitis C virus-associated liver cirrhosis with cryoglobulinemia, esophageal varices and ascites treated with pegylated interferon-α 2b and ribavirin

Kanzo ◽  
2011 ◽  
Vol 52 (3) ◽  
pp. 163-168
Author(s):  
Shin-ya Onohara ◽  
Kazufumi Dohmen ◽  
Hirofumi Tanaka ◽  
Masatora Haruno ◽  
Makoto Irie ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Esophageal Varices ◽  
Pegylated Interferon ◽  
Interferon Α

Pegylated interferon α-2a plus ribavirin for decompensated hepatitis C virus-related cirrhosis: relationship between efficacy and cumulative dose

2013 ◽  
Vol 34 (10) ◽  
pp. 1522-1531 ◽  
Author(s):  
Yan Xu ◽  
Wenqian Qi ◽  
Xu Wang ◽  
Ping Zhao ◽  
Yonggui Zhang ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Cumulative Dose ◽  
Pegylated Interferon ◽  
Interferon Α

SCH 503034, a Novel Hepatitis C Virus Protease Inhibitor, Plus Pegylated Interferon α-2b for Genotype 1 Nonresponders

2007 ◽  
Vol 132 (4) ◽  
pp. 1270-1278 ◽  
Author(s):  
Christoph Sarrazin ◽  
Regine Rouzier ◽  
Frank Wagner ◽  
Nicole Forestier ◽  
Dominique Larrey ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Protease Inhibitor ◽  
Pegylated Interferon ◽  
Interferon Α ◽  
Genotype 1

Hepatitis C virus resistance to interferon therapy: an alarming situation

2014 ◽  
Vol 9 (12) ◽  
pp. 1155-1167
Author(s):  
Sobia Kanwal ◽  
Tariq Mahmood
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Social Factors ◽  
Molecular Mechanisms ◽  
Public Health Problem ◽  
Pegylated Interferon ◽  
Host Factors ◽  
Interferon Α ◽  
Major Public Health Problem ◽  
Choice Of Treatment

AbstractHepatitis C virus is presently a major public health problem across the globe. The main objective in treating hepatitis C virus (HCV) infection is to achieve a sustained virological response (SVR). Interferon-α (IFN-α) and pegylated interferon (PegIFN) in combination with Ribavirin (RBV) are the choice of treatment nowadays against chronic hepatitis C. There are several mechanisms evolved by the hepatitis C virus that facilitate the persistence of virus and further lead the patient’s status as non responder. Various factors involved in patient’s lack ofresponse to the therapy include: (1) viral factors, (2) host factors, (3) molecular mechanisms related to the lack of response and (4) social factors. Herein we have made an attempt to summarize all the related predictors of drug resistance in one article so that the future polices can be planned to overcome this obstacle and potential therapies can be designed by considering these factors.

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