scholarly journals Usefulness of dose intensity/body surface area ratio (DI/BSA ratio; DBR) rather than relative dose intensity in the lenvatinib treatment for hepatocellular carcinoma

Kanzo ◽  
2020 ◽  
Vol 61 (3) ◽  
pp. 129-132
Author(s):  
Yuji Eso ◽  
Shigeharu Nakano ◽  
Masako Mishima ◽  
Soichi Arasawa ◽  
Eriko Iguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Dose Intensity ◽  
Area Ratio ◽  
Relative Dose Intensity ◽  
Surface Area Ratio

scholarly journals Dose Intensity/Body Surface Area Ratio is a Novel Marker Useful for Predicting Response to Lenvatinib against Hepatocellular Carcinoma

Cancers ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 49 ◽  
Author(s):  
Yuji Eso ◽  
Shigeharu Nakano ◽  
Masako Mishima ◽  
Soichi Arasawa ◽  
Eriko Iguchi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Therapeutic Response ◽  
Dose Intensity ◽  
Progression Free Survival ◽  
Area Ratio ◽  
Treatment Intensity ◽  
Surface Area Ratio

Lenvatinib was recently approved as a novel first-line molecular targeted agent (MTA) for treating hepatocellular carcinoma (HCC). The importance of relative dose intensity (RDI) has been shown in the treatment of various types of cancers. However, RDI may not accurately reflect the treatment intensity of lenvatinib, as it is the first oral MTA where the dose is based on the patient’s weight. We aimed to evaluate the utility of 2M-DBR (the delivered dose intensity/body surface area ratio at 60 days) by comparing the relationship between 2M-DBR, 2M-RDI (RDI at 60 days), and the therapeutic response. The therapeutic response to lenvatinib was evaluated in 45 patients who underwent computed tomography 8–12 weeks after treatment initiation. We also investigated the clinical factors associated with high 2M-DBR. The area under the receiver operating characteristic of 2M-DBR that predicts the response to lenvatinib was higher than that of 2M-RDI (0.8004 vs. 0.7778). Patients with high 2M-DBR achieved significantly better objective responses and disease control rates than those with low 2M-DBR (p < 0.0001 and 0.0008). Patients with high 2M-DBR experienced significantly longer progression-free survival (PFS) than those with low 2M-DBR (p = 0.0001), while there was no significant correlation between 2M-RDI levels and PFS (p = 0.2198). Patients who achieved higher levels of 2M-DBR had a significantly better modified ALBI grade (p = 0.0437), better CONUT score (p = 0.0222), and higher BTR (p = 0.0281). Multivariate analysis revealed that high 2M-DBR was the only significant factor associated with longer PFS. In conclusion, 2M-DBR could be an important factor that reflects treatment intensity and useful for predicting the response to lenvatinib against HCC, instead of 2M-RDI.

Clinical implication of renal allograft volume to recipient body surface area ratio in pediatric renal transplant

2018 ◽  
Vol 22 (8) ◽  
pp. e13295
Author(s):  
Michael E. Chua ◽  
Jin Kyu Kim ◽  
Michele Gnech ◽  
Jessica M. Ming ◽  
Bisma Amir ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Clinical Implication ◽  
Renal Allograft ◽  
Area Ratio ◽  
Surface Area Ratio ◽  
Pediatric Renal Transplant

The effect of donor/recipient body surface area ratio on outcomes in pediatric kidney transplantation

2009 ◽  
Vol 13 (3) ◽  
pp. 290-299 ◽  
Author(s):  
Stefano Giuliani ◽  
Pier Giorgio Gamba ◽  
Nikunj Kanu Chokshi ◽  
Paolo Gasparella ◽  
Luisa Murer ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Area Ratio ◽  
Surface Area Ratio ◽  
Pediatric Kidney Transplantation

scholarly journals Donor Age, Donor-Recipient Size Mismatch, and Kidney Graft Survival

2020 ◽  
Vol 15 (10) ◽  
pp. 1455-1463
Author(s):  
Fanny Lepeytre ◽  
Catherine Delmas-Frenette ◽  
Xun Zhang ◽  
Stéphanie Larivière-Beaudoin ◽  
Ruth Sapir-Pichhadze ◽  
...  
Keyword(s):  
Surface Area ◽  
Body Surface Area ◽  
Graft Survival ◽  
Body Surface ◽  
Area Ratio ◽  
Transplant Recipients ◽  
Donor Age ◽  
Surface Area Ratio ◽  
Size Mismatch ◽  
Recipient Age

Background and objectivesSmall donor and/or kidney sizes relative to recipient size are associated with a higher risk of kidney allograft failure. Donor and recipient ages are associated with graft survival and may modulate the relationship between size mismatch and the latter. The aim of this study was to determine whether the association between donor-recipient size mismatch and graft survival differs by donor and recipient age.Design, setting, participants, & measurementWe performed a retrospective cohort study of first adult deceased donor kidney transplantations performed between 2000 and 2018 recorded in the Scientific Registry of Transplant Recipients. We used multivariable Cox proportional hazards models to assess the association between donor-recipient body surface area ratio and death-censored graft survival, defined as return to dialysis or retransplantation. We considered interactions between donor-recipient body surface area ratio and each of recipient and donor age.ResultsAmong the 136,321 kidney transplant recipients included in this study, 23,614 (17%) experienced death-censored graft loss over a median follow-up of 4.3 years (interquartile range, 1.9–7.8 years). The three-way donor-recipient body surface area ratio by donor age by recipient age interaction was statistically significant (P=0.04). The magnitude of the association between severe size mismatch (donor-recipient body surface area ratio <0.80 versus ≥1.00) and death-censored graft survival was stronger with older donor age and recipient age. In all recipient age categories except the youngest (18–30 years), 5- and 10-year graft survival rates were similar or better with a size-mismatched donor aged <40 years than a nonsize-mismatched donor aged 40 years or older.ConclusionsThe association of donor-recipient size mismatch on long-term graft survival is modulated by recipient and donor age. Size-mismatched kidneys yield excellent graft survival when the donor is young. Donor age was more strongly associated with graft survival than size mismatch.

Neither toxicity nor dose intensity of carboplatin is affected by glomerular filtration rate versus body surface area dose calculation in gynecologic malignancy

1994 ◽  
Vol 4 (5) ◽  
pp. 315-319 ◽  
Author(s):  
K. S. Tonkin ◽  
L. Levin ◽  
J. Powe
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Filtration Rate ◽  
Area Under The Curve ◽  
Dose Intensity ◽  
Dose Schedule ◽  
Percentage Difference

Twelve patients were given 31 courses of carboplatin using a glomerular filtration rate (GFR)-based area under the curve (AUC) dose schedule, and nine patients were given 35 cycles at a body surface area (BSA) dose of 350 mg m−2 every 3 weeks. The GFR was determined using technetium-99m-DTPA. The dose given was calculated according to AUC, 5 for previously treated and 7 for previously untreated patients × GFR + 25. Patients treated using the GFR had a 22% lower projected dose intensity (DI) and a 15% lower received DI compared with controls. The percentage difference between the received and projected DI was not different between the two groups of patients. In 11 of 12 patients treated according to the GFR, if the BSA calculation dose had been used it would have resulted in a higher dose of carboplatin. Twenty per cent (six of 30 courses) of GFR-based doses were delayed compared to 29% (10 of 35) of the BSA-calculated control groups. We conclude that giving a dose according to a BSA of 350 mg m−2 leads to a higher DI and total dose and does not substantially effect toxicity. It is also cost effective as it eliminates the need for unnecessary radiometric GFR determination.

Infection Risk Factors in Pediatric Cardiac Surgery

2002 ◽  
Vol 10 (4) ◽  
pp. 329-333 ◽  
Author(s):  
Wojciech Mrowczynski ◽  
Michal Wojtalik ◽  
Danuta Zawadzka ◽  
Girish Sharma ◽  
Jacek Henschke ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Intensive Care ◽  
Surface Area ◽  
Body Surface Area ◽  
Body Surface ◽  
Heart Surgery ◽  
Positive Culture ◽  
Surface Area Ratio ◽  
Surface Areas ◽  
Infection Risk Factors

Cardiac operations were preformed in 499 children from January 1998 through December 1999. Their median age was 263 days. A positive culture from blood, bronchoalveolar lavage, wound, or central catheter was obtained in 110 patients (22%). Age, sex, presence of pulmonary hypertension, body surface area, ratio of body surface area to oxygenator surface area, whether heart surgery was open or closed, and the duration of the operation, cardiopulmonary bypass, intubation, and intensive care were analyzed. Patients who developed infections were significantly younger, with smaller body surface areas and disparity with the oxygenator surface area, longer operative and bypass times, extended intubation, and prolonged intensive care. There was a significant correlation between infection and pulmonary hypertension. Sex and type of operation were not predictors of infection.

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