Added Value of Digital Over Analog PET/CT: More Significant as Image Field of View (FOV) and Body Mass Index (BMI) Increases

Abstract BackgroundTime-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low counts acquisitions, such as in overweight patients, allowing a reduction of administered activity and/or imaging time. However, international guidelines and recommendations on 18F-fluoro-2-deoxyglucose (FDG) activity administration scheme are old or only partially account for TOF technology and advanced reconstruction modalities. The aim of this study was to optimize FDG whole-body studies on a TOF PET/CT scanner by using a multivariate approach to quantify how physical figures of merit related to image quality change with acquisition/reconstruction/patient-dependent parameters in a phantom experiment. MethodsThe NEMA-IQ phantom was used to evaluate contrast recovery coefficient (CRC), background variability (BV) and contrast-to-noise ratio (CNR) as a function of changing emission scan duration (ESD), activity concentration (AC), target internal diameter (ID), target-background activity ratio (TBR), and body mass index (BMI). The phantom was filled with an average concentration of 5.3 kBq/mL of FDG solution and the spheres with TBR of 21.2, 8.8, and 5.0 in 3 different sessions. Images were acquired at varying background activity concentration from 5.1 to 1.3 kBq/mL and images were reconstructed for ESD of 30-151 seconds per bed position with and without Point Spread Function (PSF) correction. The parameters were all considered in a single analysis using multiple linear regression methods. ResultsAs expected, CRC depended only on sphere ID and on PSF application, while BV depended on sphere ID, ESD, AC and BMI of the phantom, in order of decreasing relevance. Noteworthy, ESD and AC resulted as the most significant predictors of CNR variability with a similar relevance, followed by the weight of the patient and TBR of the lesion. ConclusionsAC and ESD proved to be effective tools in modulating CNR. ESD could be increased rather than AC to improve image quality in overweight/obese patients to fulfil ALARA principles.

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Benefits of Point-Spread Function and Time of Flight for PET/CT Image Quality in Relation to the Body Mass Index and Injected Dose

Clinical Nuclear Medicine ◽

10.1097/rlu.0b013e31828da3bd ◽

2013 ◽

Vol 38 (6) ◽

pp. 407-412 ◽

Cited By ~ 13

Author(s):

Go Akamatsu ◽

Katsuhiko Mitsumoto ◽

Kaori Ishikawa ◽

Takafumi Taniguchi ◽

Nobuyoshi Ohya ◽

...

Keyword(s):

Body Mass Index ◽

Image Quality ◽

Body Mass ◽

Point Spread Function ◽

The Body ◽

Ct Image ◽

Point Spread ◽

Pet Ct ◽

Spread Function ◽

Ct Image Quality

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Whole-Body PET/CT Studies with Lowered 18F-FDG Doses: The Influence of Body Mass Index in Dose Reduction

Journal of Nuclear Medicine Technology ◽

10.2967/jnmt.113.130393 ◽

2014 ◽

Vol 42 (1) ◽

pp. 62-67 ◽

Cited By ~ 5

Author(s):

R. Sanchez-Jurado ◽

M. Devis ◽

R. Sanz ◽

J. E. Aguilar ◽

M. d. Puig Cozar ◽

...

Keyword(s):

Body Mass Index ◽

Dose Reduction ◽

Body Mass ◽

Whole Body ◽

Pet Ct ◽

18F Fdg ◽

Ct Studies

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Variations of the hepatic SUV in relation to the body mass index in whole body PET-CT studies

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) ◽

10.1016/j.remnie.2012.11.004 ◽

2013 ◽

Vol 32 (1) ◽

pp. 26-32

Author(s):

S.M. Batallés ◽

R.L. Villavicencio ◽

A. Quaranta ◽

L. Burgos ◽

S. Trezzo ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

The Body ◽

Whole Body ◽

Pet Ct ◽

Ct Studies

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The role of activity, scan duration and patient’s body mass index in the optimization of FDG imaging protocols on a TOF-PET/CT scanner

EJNMMI Physics ◽

10.1186/s40658-021-00380-9 ◽

2021 ◽

Vol 8 (1) ◽

Author(s):

Roberta Matheoud ◽

Naema Al-Maymani ◽

Alessia Oldani ◽

Gian Mauro Sacchetti ◽

Marco Brambilla ◽

...

Keyword(s):

Body Mass Index ◽

Image Quality ◽

Body Mass ◽

Activity Concentration ◽

Background Activity ◽

Whole Body ◽

Internal Diameter ◽

Ct Scanner ◽

Pet Ct ◽

Tof Pet

Abstract Background Time-of-flight (TOF) PET technology determines a reduction in the noise and improves the reconstructed image quality in low count acquisitions, such as in overweight patients, allowing a reduction of administered activity and/or imaging time. However, international guidelines and recommendations on the 18F-fluoro-2-deoxyglucose (FDG) activity administration scheme are old or only partially account for TOF technology and advanced reconstruction modalities. The aim of this study was to optimize FDG whole-body studies on a TOF-PET/CT scanner by using a multivariate approach to quantify how physical figures of merit related to image quality change with acquisition/reconstruction/patient-dependent parameters in a phantom experiment. Methods The NEMA-IQ phantom was used to evaluate contrast recovery coefficient (CRC), background variability (BV) and contrast-to-noise ratio (CNR) as a function of changing emission scan duration (ESD), activity concentration (AC), target internal diameter (ID), target-background activity ratio (TBR) and body mass index (BMI). The phantom was filled with an average concentration of 5.3 kBq/ml of FDG solution and the spheres with TBR of 21.2, 8.8 and 5.0 in 3 different sessions. Images were acquired at varying background activity concentration from 5.1 to 1.3 kBq/ml, and images were reconstructed for ESD of 30–151 s per bed position with and without point spread function (PSF) correction. The parameters were all considered in a single analysis using multiple linear regression methods. Results As expected, CRC depended only on sphere ID and on PSF application, while BV depended on sphere ID, ESD, AC and BMI of the phantom, in order of decreasing relevance. Noteworthy, ESD and AC resulted as the most significant predictors of CNR variability with a similar relevance, followed by the BMI of the patient and TBR of the lesion. Conclusions AC and ESD proved to be effective tools in modulating CNR. ESD could be increased rather than AC to improve image quality in overweight/obese patients to fulfil ALARA principles.

Download Full-text