Nursing Technology in Vibration Perception Threshold Testing in Diabetic Peripheral Neuropathy Patients

Foot ulcers, infections, and deformity are some of the major sources of mortality and morbidity among the diabetic population. The relationship between glycated hemoglobin (HbA1c) and diabetic peripheral neuropathy (DPN) has been well established. There is a dearth of literature on the relationship between vibration perception threshold (VPT) and HbA1c values. So, the objective of the study was to determine the strength of linear relationship between HbA1c levels and vibration perception threshold in DPN. This cross-sectional study was conducted at Kasturba Hospital, Manipal, and diabetic foot screening camps held at various parts of Udupi district. Ethical approval was obtained from the Institutional Ethics Committee, Kasturba Hospital, Manipal (IEC:281/2017). A total of 534 participants ranging from 30 to 70 years of age and were diagnosed with type 2 diabetes mellitus on medications were included in the study. Neuropathy assessment consisting of monofilament and vibration perception threshold was done using Neurotouch beta version (Yostra Labs, Bengaluru, India). HbA1c measurement was done using turbidimetric inhibition immunoassay technique (Roche Diagnostics, Mannheim, Germany). Pearson correlation coefficient showed a moderate to good correlation between HbA1c and VPT ( r = .0.753, P < .001). Linear regression result has shown a significant relationship of VPT with HbA1c (4.033 [95% confidence interval = 3.67-4.39]). The present study has concluded that there is strong relationship between HbA1c values and VPT and could be a predictor for complications in the foot following DPN.

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The Semmes -Weinstein monofilament examination as a single effective screening tool in the evaluation of diabetic peripheral neuropathy when compared to vibration perception threshold

National Journal of Physiology Pharmacy and Pharmacology ◽

10.5455/njppp.2020.10.03076202028032020 ◽

2020 ◽

pp. 1

Author(s):

Subathra Ammaiyappan ◽

Babitha Rangarajan

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Screening Tool ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Effective Screening ◽

Vibration Perception

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Vibration Perception Threshold Values and Clinical Symptoms of Diabetic Peripheral Neuropathy

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2018/32825.11549 ◽

2018 ◽

Author(s):

Anirudhan Arya Medakkel ◽

Pavithran Sheela

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Clinical Symptoms ◽

Threshold Values ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Vibration Perception

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Diagnostic Value of Vibration Perception Threshold in Diabetic Peripheral Neuropathy

International Journal of Physiology ◽

10.5958/2320-608x.2018.00091.4 ◽

2018 ◽

Vol 6 (3) ◽

pp. 84

Author(s):

C Bharathi ◽

M S Roopakala ◽

C Shivaprasad ◽

P T Acharya

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Diagnostic Value ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Vibration Perception

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Diagnostic accuracy of monofilament test to detect diabetic neuropathy

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v10i1.37086 ◽

2021 ◽

Vol 10 (1) ◽

pp. 20-25

Author(s):

Sujan Shrestha ◽

Mamen Prasad Gorhaly ◽

Manil Ratna Bajracharya

Keyword(s):

Peripheral Neuropathy ◽

Positive Predictive Value ◽

Diagnostic Accuracy ◽

Negative Predictive Value ◽

Predictive Value ◽

Diabetic Peripheral Neuropathy ◽

Perception Threshold ◽

Sensitivity Specificity ◽

Vibration Perception ◽

Monofilament Test

Background Diabetic peripheral neuropathy (DPN) is a significant independent risk factor for diabetic foot, and an effective screening instrument is required to diagnose DPN early to prevent future ulceration and amputation. This study aims to determine the diagnostic accuracy of monofilament test to detect diabetic peripheral neuropathy. Methods This cross-sectional study was conducted in National Academy of Medical Sciences, Bir hospital, Mahabouddha, Kathmandu from February 2016 to January 2017. A total of 96 diabetic patients attending inpatient and outpatient Department were selected. Diabetic peripheral neuropathy was assessed by measurement of loss of protective sensation (LOPS) by monofilament test and compared with vibration perception threshold by standard biothesiometer. The sensitivity, specificity, positive predictive value and negative predictive value of monofilament test were calculated. Results The prevalence of diabetic peripheral neuropathy was 26%. The sensitivity, specificity, positive predictive value and negative predictive value of monofilament test were found to be 92.0%, 95.8%, 88.5% and 97.1% respectively. There was strong association between LOPS by monofilament and vibration perception threshold by biothesiometer. Conclusion This study showed a strong diagnostic accuracy of monofilament test to detect DPN when compared with biothesiometer. As monofilament test is a cheap, easily available, and portable, it can be used in the periphery where biothesiometer is not available.

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Vibration Perception Threshold as a Measure of Distal Symmetrical Peripheral Neuropathy in Type 1 Diabetes: Results from the DCCT/EDIC study

Diabetes Care ◽

10.2337/dc10-0616 ◽

2010 ◽

Vol 33 (12) ◽

pp. 2635-2641 ◽

Cited By ~ 43

Author(s):

C. L. Martin ◽

B. H. Waberski ◽

R. Pop-Busui ◽

P. A. Cleary ◽

S. Catton ◽

...

Keyword(s):

Type 1 Diabetes ◽

Peripheral Neuropathy ◽

Perception Threshold ◽

Vibration Perception Threshold ◽

Vibration Perception

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Prealbumin to fibrinogen ratio is closely associated with diabetic peripheral neuropathy

Endocrine Connections ◽

10.1530/ec-20-0316 ◽

2020 ◽

Vol 9 (8) ◽

pp. 858-863

Author(s):

Shufei Zang ◽

Lei Shi ◽

Jinying Zhao ◽

Min Yang ◽

Jun Liu ◽

...

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Nerve Conduction Velocity ◽

Roc Analysis ◽

Diagnostic Value ◽

Related Factors ◽

Perception Threshold ◽

Area Under Roc Curve ◽

Vibration Perception

The aim of our study was to explore the diagnostic value of prealbumin to fibrinogen ratio (PFR) for predicting prognosis with the optimal cut-off value in diabetic peripheral neuropathy (DPN) patients. A total of 568 type 2 diabetes mellitus (T2DM) patients were enrolled in this study. The values including Toronto clinical neuropathy score (TCNS), nerve conduction velocity (NCV), vibration perception threshold (VPT), blood cells count, biochemical parameters, fibrinogen and PFR were recorded. The patients were divided into tertiles based on admission PFR value. First, clinical parameters were compared among the groups. Secondly, a logistic regression and ROC analysis were performed as the statistical model. The percentage of DPN, TCNS and VPT were significantly higher in the lowest PFR tertile than in the middle PFR tertile and the highest PFR tertile (P < 0.01–0.001). NCV was significantly lower in lowest PFR tertile than in the middle PFR tertile and the highest PFR tertile (P < 0.01–0.001). The Spearman correlation analysis showed that PFR was negatively correlated with TCNS and VPT (P < 0.001), while PFR was positively correlated with median motor NCV (P < 0.001), peroneal motor NCV (P < 0.001), median sensory NCV (P < 0.001), and peroneal sensory NCV (P < 0.001). After adjusting these potentially related factors, PFR was independently related to DPN (P = 0.007). The area under ROC curve was 0.627. This study finds the first evidence to suggest PFR may be the key component associated with DPN in T2DM, while PFR might underlie the pathophysiologic features of DPN.

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