Case Report:Granular Cell Tumor In Breast

Granular cell tumor (GCT) of the breast is an unusual neoplasm, tipically benign, it represents between 5-6% of all GCT cases. These tumors are more common in middle-aged premenopausal women with a greater predilection African American race. Nevertheless, there are also cases described in men , , . Almost all of them are favorable, the malignant cases are uncommon (only 1-3%). Sometimes it could be clinically and radiologically confused with a malignant breast tumor; so it's very important to make a differential diagnosis. The choice therapy is an extensive local extirpation with free margins, without the need for adjuvant chemotherapy or radiotherapy. Our case is a 61-year-old woman with a GCT, and three years ago a history of breast carcinoma in the same breast.

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A Rare Case of a Metastatic Malignant Abrikossoff Tumor

Case Reports in Oncology ◽

10.1159/000520385 ◽

2021 ◽

pp. 1868-1875

Author(s):

Mohamed Tayeb Salaouatchi ◽

Sandra De Breucker ◽

Héloise Rouvière ◽

Véronique Lesage ◽

Laureen Jeanne Armande Rocq ◽

...

Keyword(s):

Granular Cell Tumor ◽

Soft Tissues ◽

Granular Cell ◽

Cell Tumor ◽

Benign Tumors ◽

Large Size ◽

Positron Emission ◽

History Of ◽

Malignant Granular Cell Tumor ◽

Malignant And Benign Tumors

Abrikossoff tumor, also called granular cell tumor (GCT), is a neoplasm of the soft tissues which is most commonly a solitary, painless, and benign tumor. However, 2% of Abrikossoff tumors can be malignant. We report here the case of a 75-year-old male who presented a local recurrence of Abrikossoff tumor of the left thigh. The anatomopathological analysis concluded to a malignant GCT, and the F-18 fluorodeoxyglucose positron emission tomography showed multiple lesions in the lymph nodes and bones. The potential conversion to malignancy should alert practitioners because of the extremely poor prognosis. The diagnosis of malignant granular cell tumor should be based on a bundle of clinical and histological features and not solely on histologic features because of the challenging distinction between malignant and benign tumors due to the lack of well-defined criteria for the diagnosis of malignancy. Large size and recurrence are the most important clinical features predicting malignant behavior. Patients with a history of Abrikossoff tumor should be followed closely to monitor recurrence and malignant transformation. The apparent originality of our observation – which could lie in the evolution of a GCT tumor, initially considered as benign, to a malignant form – has to be challenged regarding the issue of classifying some cases according to the classical “benign” and “malignant” dichotomy.

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The Unique Simultaneous Occurrence of Granular Cell Tumor, Gastrointestinal Stromal Tumor, and Gastric Adenocarcinoma

Archives of Pathology & Laboratory Medicine ◽

10.5858/2005-129-e121-tusoog ◽

2005 ◽

Vol 129 (5) ◽

pp. e121-e123

Author(s):

Joseph L. Sailors ◽

Samuel W. French

Keyword(s):

Gastrointestinal Stromal Tumor ◽

Gastric Adenocarcinoma ◽

Granular Cell Tumor ◽

Granular Cell ◽

Cell Tumor ◽

Stromal Tumor ◽

Simultaneous Occurrence ◽

First Case ◽

History Of ◽

Schwannian Origin

Abstract Granular cell tumors are generally benign oncocytoid lesions of schwannian origin that are often incidental findings in many locations. Gastrointestinal stromal tumors occur in older adults and express the c-Kit protein (CD117). Both of these tumors have been described in association with many other entities; however, they have never been reported to occur jointly. This report is prompted by the simultaneous appearance of 2 granular cell tumors, a gastrointestinal stromal tumor, and a gastric adenocarcinoma in a 65-year-old woman with a history of breast carcinoma and granular cell tumor. To our knowledge, this is the first case report of these tumors occurring simultaneously.

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Granular Cell Tumor Presenting as a Tracheal Mass in a 17-year-old Female

Philippine Journal of Otolaryngology Head and Neck Surgery ◽

10.32412/pjohns.v23i1.777 ◽

2008 ◽

Vol 23 (1) ◽

pp. 39-40

Author(s):

Jose M. Carnate ◽

Audie G. Silva

Keyword(s):

Tumor Cells ◽

Granular Cell Tumor ◽

S100 Protein ◽

Granular Cell ◽

Surgical Excision ◽

Cell Tumor ◽

Granular Cytoplasm ◽

History Of ◽

Infiltrative Growth Pattern ◽

One Year

Granular cell tumors involving the trachea are rare. We present the case of a seventeen year old female with a one year history of gradually worsening dyspnea necessitating a tracheotomy. A suprastomal intraluminal tracheal mass was excised. Histologic sections (Figure 1) show a poorly circumscribed neoplasm infiltrating through the tracheal cartilage. It is composed of polygonal to somewhat elongated tumor cells that have small, dark nuclei. The cytoplasm is ample, eosinophilic and strikingly granular in quality. The cell borders are ill-defined creating a `syncytial’ pattern of dark nuclei scattered in a sea of granular cytoplasm. The diagnosis was a granular cell tumor. Immunohistochemistry (Figure 2) revealed strong, diffuse cytoplasmic positivity for S100 protein, attesting to its neural crest histogenesis. The infiltrative growth pattern may momentarily raise the question of malignancy but this is dispelled by awareness that infiltration is the natural history for all granular cell tumors, benign or malignant. Histologically, malignancy is diagnosed if three or more of the following are present: necrosis, spindling of tumor cells, vesicular nuclei with large nucleoli, greater than 2 mitoses per ten high power fields, high nucleus-to-cytoplasm ratio and nuclear pleomorphism. None was present in our case. Surgical excision remains the mainstay of treatment.

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Colocalized Granular Cell Tumor and Infiltrating Ductal Carcinoma of the Breast

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-0731-cgctai ◽

2002 ◽

Vol 126 (6) ◽

pp. 731-733 ◽

Cited By ~ 4

Author(s):

Hikmat Al-Ahmadie ◽

Per-Olof Hasselgren ◽

Rawia Yassin ◽

George Mutema

Keyword(s):

Invasive Ductal Carcinoma ◽

Granular Cell Tumor ◽

Ductal Carcinoma ◽

Granular Cell ◽

Cell Tumor ◽

Palpable Mass ◽

First Case ◽

History Of ◽

Well Differentiated ◽

The Right

Abstract A 57-year-old woman presented with a 2-year history of a palpable mass in the upper inner quadrant of the right breast. A 1.1-cm, poorly circumscribed, firm tumor nodule was noted, consisting of 2 histologically distinct lesions in the same location, with some areas showing purely well-differentiated invasive ductal carcinoma and others composed of granular cell tumor. In 1 area, the 2 tumors collided and infiltrated each other. The invasive ductal carcinoma was admixed with ductal carcinoma in situ of solid and cribriform types. To our knowledge, this is the first case report demonstrating colocalization of these 2 neoplasms, which raises questions regarding causal relationship. We also review the literature on granular cell tumor of the breast.

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Cutaneous granular cell tumor: A case report

Journal of Pathology of Nepal ◽

10.3126/jpn.v9i1.23384 ◽

2019 ◽

Vol 9 (1) ◽

pp. 1511-1513

Author(s):

Deliya Paudel ◽

Ram Chandra Adhikari

Keyword(s):

Soft Tissue ◽

Granular Cell Tumor ◽

Histopathological Examination ◽

Benign Neoplasm ◽

Granular Cell ◽

Soft Tissue Tumors ◽

Cell Tumor ◽

Internal Organs ◽

History Of ◽

Biliary Ducts

Granular cell tumor is a rare benign neoplasm of the skin that accounts for 0.5% of all soft-tissue tumors. Granular cell tumor can affect both sexes and in any age, although it is most common in females. The common locations are the head and neck, the tongue is affected in 25% of cases but any internal organs can be affected such as soft tissue, bronchus, stomach, rectum, anus, biliary ducts. Here, we report a 58-year-old female patient who presented with a 4-year history of a slowly growing mass, with a dimension of 5 × 4 cm on her left waist, diagnosed as a Granular cell tumor at histopathological examination.

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