Correlation of fetal hemoglobin in different cancer patients and sickle cell anaemia: A review

Fetal hemoglobin is the main hemoglobin during gestation period. But this globin chain is replaced and is taken over by adult hemoglobin. Sometimes this switch from fetal to adult fails to occur leading to production of fetal hemoglobin as in case of sickle cell anemia. It is also observed that fetal hemoglobin expression is also seen under malignant condition. In malignancy the spleen, liver as well as gut acquire its ability to produce fetal hemoglobin. Certain HbF cells inducing factor such as stem cell growth factor and interleukin -3 also promote HbF erythropoiesis. HbF cells are indicated as a biomarker of tumour cells implicated in many carcinomas observed by immunohisto chemical investigations.

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Stem cell growth factor receptor in canine vs. feline osteosarcomas

Oncology Letters ◽

10.3892/ol.2016.5006 ◽

2016 ◽

Vol 12 (4) ◽

pp. 2485-2492 ◽

Cited By ~ 3

Author(s):

Birgitt Wolfesberger ◽

Andrea Fuchs-Baumgartinger ◽

Juraj Hlavaty ◽

Florian R. Meyer ◽

Martin Hofer ◽

...

Keyword(s):

Stem Cell ◽

Growth Factor ◽

Cell Growth ◽

Growth Factor Receptor ◽

Stem Cell Growth Factor ◽

Cell Growth Factor Receptor

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Application of stem cell/growth factor system, as a multimodal therapy approach in regenerative medicine to improve cell therapy yields

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.02.006 ◽

2014 ◽

Vol 173 (1) ◽

pp. 12-19 ◽

Cited By ~ 19

Author(s):

Fatemeh Pourrajab ◽

Mojtaba Babaei Zarch ◽

Mohammad Baghi Yazdi ◽

Abolfazl Rahimi Zarchi ◽

Abbas Vakili Zarch

Keyword(s):

Stem Cell ◽

Growth Factor ◽

Cell Growth ◽

Regenerative Medicine ◽

Cell Therapy ◽

Multimodal Therapy ◽

Therapy Approach ◽

Factor System ◽

Stem Cell Growth Factor

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Dickkopf 1 (Dkk1) Regulates Hematopoietic Stem Cell Regeneration

Blood ◽

10.1182/blood.v126.23.1200.1200 ◽

2015 ◽

Vol 126 (23) ◽

pp. 1200-1200

Author(s):

Heather A Himburg ◽

Phuong L Doan ◽

Xiao Yan ◽

Mamle Quarmyne ◽

Liman Zhao ◽

...

Keyword(s):

Stem Cell ◽

Growth Factor ◽

Cell Growth ◽

Hematopoietic Stem Cell ◽

Systemic Administration ◽

Hematopoietic Stem ◽

University Patents ◽

Duke University ◽

Osteolineage Cells ◽

Stem Cell Growth Factor

Abstract Bone marrow endothelial cells (BM ECs) have been shown to regulate HSC regeneration following myelosuppression. The role of osteolineage cells in regulating HSC regeneration remains less well understood. Here, we show that deletion of the pro-apoptotic genes, Bak and Bax, in osterix (Osx)-expressing osteoprogenitor cells promoted HSC regeneration and hematopoietic radioprotection of mice following total body irradiation (TBI). We identified Dkk1 to be enriched in the BM of radioprotected OsxCre;Bak1-/-;BaxFL/- mice and found that Bak /Bax-deficient osteolineage cells expressed increased levels of Dkk1 compared to Bax-expressing osteolineage cells (p=0.003). Treatment of irradiated BM HSCs with DKK1 in vitro significantly increased the recovery of phenotypic HSCs (p=0.0002), colony forming cells (CFCs)(p=0.003) and long-term repopulating HSCs compared to control cultures (p=0.009). Systemic administration of Dkk1 to lethally irradiated C57Bl6 mice accelerated the recovery of mature blood counts (p=0.008), BM HSCs (p=0.008) and progenitor cells (p=0.007). Furthermore, survival after lethal irradiation was markedly increased in Dkk1 treated mice (93%) compared to saline controls (27%; p=0.0004). Conversely, systemic administration of anti-Dkk1 antibody significantly delayed recovery of BM HSCs (p=0.002), peripheral white blood cells (p=0.0004), neutrophils (p<0.0001) and lymphocytes (p=0.002) in irradiated mice compared to irradiated, control mice. Dkk1 promoted HSC regeneration via suppression of reactive oxygen species (ROS) and inhibition of caspase activation in HSCs following irradiation. Dkk1 represents a novel, osteoprogenitor cell-derived paracrine factor which is necessary for normal hematopoietic regeneration following irradiation and can be therapeutically delivered to accelerate hematopoietic reconstitution. Disclosures Himburg: Duke University: Patents & Royalties: Patent Application for use of Pleiotrophin as a hematopoietic stem cell growth factor. Chute:C2 Regenerate: Equity Ownership; Duke University: Patents & Royalties: Application to use PTN as growth factor as hematopoietic stem cell growth factor.

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