scholarly journals Debatable aspects of systemic angiitis and autoinfl ammatory diseases

2021 ◽  
Vol 99 (4) ◽  
pp. 314-320
Author(s):  
N. P. Shilkina ◽  
I. V. Dryazhenkova ◽  
I. E. Yunonin ◽  
Zh. E. Chetvertakova
Keyword(s):  
Retrospective Analysis ◽  
Rheumatic Diseases ◽  
Consensus Conference ◽  
Therapy Recommendations ◽  
Chapel Hill ◽  
Chapel Hill Consensus Conference ◽  
Hyperimmunoglobulinemia E ◽  
Second International

The new data about immune-infl ammatory rheumatic diseases pathogenesis with the participation of the processes of autoimmunity and autoinfl ammation attract attention to the heterogeneity of systemic angiitis, their nomenclature, classifi cation, pathogenesis and the approaches to the therapy. Recommendations of the second International Chapel Hill Consensus Conference (CHCC2012) and EULAR recommendation (2016, 2018) regarding diagnostics and treatment of SA are discussed. The data of 141 patients with various forms of SA and 18 patients with the diseases, which relate to the group of autoinfl ammatory processes as well as the retrospective analysis of 130 patients with the hyperimmunoglobulinemia E are given.

scholarly journals 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

2012 ◽  
Vol 65 (1) ◽  
pp. 1-11 ◽  
Author(s):  
J. C. Jennette ◽  
R. J. Falk ◽  
P. A. Bacon ◽  
N. Basu ◽  
M. C. Cid ◽  
...  
Keyword(s):  
Consensus Conference ◽  
Chapel Hill ◽  
Chapel Hill Consensus Conference

scholarly journals CT Features of Vasculitides Based on the 2012 International Chapel Hill Consensus Conference Revised Classification

2017 ◽  
Vol 18 (5) ◽  
pp. 786 ◽  
Author(s):  
Jee Hye Hur ◽  
Eun Ju Chun ◽  
Hyon Joo Kwag ◽  
Jin Young Yoo ◽  
Hae Young Kim ◽  
...  
Keyword(s):  
Consensus Conference ◽  
Chapel Hill ◽  
Chapel Hill Consensus Conference ◽  
Ct Features

Small vessel vasculitis

2020 ◽  
pp. 4573-4579
Author(s):  
Richard A. Watts
Keyword(s):  
Antineutrophil Cytoplasmic Antibody ◽  
Consensus Conference ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Iga Vasculitis ◽  
Small Vessels ◽  
Chapel Hill ◽  
Familial Association ◽  
Chapel Hill Consensus Conference ◽  
Inflammatory Drugs

Small vessel vasculitis is vasculitis affecting predominately small intraparenchymal arteries, arterioles, capillaries, and venules. There are two main types: antineutrophil cytoplasmic antibody associated and immune complex mediated. The ANCA associated vasculitides are discussed in chapter 19.3 IgA vasculitis (IgAV) was formerly known as Henoch Schönlein purpura. The revised nomenclature reflects the importance of IgA vasculitis in pathogenesis. The Chapel Hill Consensus Conference defined IgA vasculitis as ‘vasculitis with IgA1-dominant immune deposits, affecting small vessels (predominantly capillaries, venules, or arterioles)’. IgA vasculitis often involves skin and gut, and frequently causes arthritis. Glomerulonephritis indistinguishable from IgA nephropathy may occur. Its aetiology is unknown, but it frequently occurs after an infection several days to weeks before. The most frequently isolated organism is beta-haemolytic streptococcus. Drugs such as a penicillin, ampicillin, erythromycin, and non-steroidal anti-inflammatory drugs have been reported as precipitating agents. There is an association with HLA-DRB1*01 in Caucasians and there appears to be a familial association.

scholarly journals Clinical features of kidney involvement in microscopic microscopic polyangiitis

2018 ◽  
Vol 90 (6) ◽  
pp. 55-58
Author(s):  
E M Shchegoleva ◽  
N M Bulanov ◽  
P I Novikov ◽  
S V Moiseev
Keyword(s):  
Clinical Features ◽  
Microscopic Polyangiitis ◽  
Renal Involvement ◽  
Rapidly Progressive Glomerulonephritis ◽  
Evaluation Agency ◽  
Consensus Conference ◽  
Chapel Hill ◽  
Kidney Involvement ◽  
Chapel Hill Consensus Conference ◽  
Rapidly Progressive Renal Failure

Aim. To evaluate clinical features and outcomes of renal involvement in patients with microscopic polyangiitis (MPA). Materials and methods: We enrolled 99 patients with MPA, diagnosed in accordance with the algorithm of the European Medicines Evaluation Agency (EMEA) and the Chapel Hill consensus conference definition (2012). Serum creatinine (sCr), estimated glomerular filtration rate (eGFR), hematuria and proteinuria were estimated. Frequency of rapidly progressive renal failure (a twofold increase in the sCr level in ≤3 months) was regarded as the clinical equivalent of rapidly progressive glomerulonephritis (RPGN). Results and discussion. Renal involvement was present in 92 (92.9%) patients. RPGN developed in 51 (55,4%) patients. The most common features of kidney involvement were hematuria and subnephrotic proteinuria. Arterial hypertension was revealed in 32 (34.7%) patients and was associated with RPGN (p

scholarly journals Proposal for a more practical classification of antineutrophil cytoplasmic antibody-associated vasculitis

2020 ◽  
Author(s):  
Nestor Oliva-Damaso ◽  
Andrew S Bomback
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Clinical Information ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Consensus Conference ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Chapel Hill ◽  
Chapel Hill Consensus Conference ◽  
Eosinophilic Granulomatosis ◽  
Relapse Rates

Abstract The nomenclature for antineutrophil cytoplasmic antibody (ANCA)-associated kidney disease has evolved from honorific eponyms to a descriptive-based classification scheme (Chapel Hill Consensus Conference 2012). Microscopic polyangiitis, granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis do not correlate with presentation, response rates and relapse rates as when comparing myeloperoxidase versus leukocyte proteinase 3. Here we discuss the limitations of the currently used classification and propose an alternative, simple classification according to (i) ANCA type and (ii) organ involvement, which provides important clinical information of prognosis and outcomes.

scholarly journals An Atypical Case of Vasculitis: When ‘Occult’ 18FDG-PET Scan Findings Create a Classification Dilemma

2019 ◽  
Author(s):  
Elena Lopez-Francos ◽  
Sammy Place ◽  
Daphnee Delplace ◽  
Frédéric Vandergheynst
Keyword(s):  
Systemic Vasculitis ◽  
Consensus Conference ◽  
Pet Scan ◽  
Recurrent Ulcer ◽  
Vessel Size ◽  
Cutaneous Polyarteritis Nodosa ◽  
Chapel Hill ◽  
18Fdg Pet ◽  
Chapel Hill Consensus Conference

We describe a 66-year old patient with a recurrent ulcer on her right ankle. Biopsy revealed medium-vessel vasculitis consistent with cutaneous polyarteritis nodosa. There were no signs or symptoms suggestive of systemic vasculitis, but a 18FDG-PET scan showed areas of increased uptake around the large arteries and the pelvic and shoulder girdles. These findings suggested polymyalgia rheumatica in the setting of large-vessel vasculitis. This case thus supports the statement from the Chapel-Hill consensus conference that classification of systemic vasculitis by vessel size is based on the vessels predominantly involved, but vessels of other sizes may also be affected.

Vasculitis—classification and diagnosis

2013 ◽  
pp. 1081-1089
Author(s):  
Richard A. Watts ◽  
David G. I. Scott
Keyword(s):  
Renal Involvement ◽  
Consensus Conference ◽  
Cytotoxic Agents ◽  
Unknown Aetiology ◽  
American College Of Rheumatology ◽  
Chapel Hill ◽  
Chapel Hill Consensus Conference ◽  
Potential Alternative ◽  
High Index Of Suspicion

The vasculitides are a group of conditions characterized by inflammation and necrosis of blood vessels; they are generally of unknown aetiology. The classification of vasculitides is based on the size of vessel involved and whether there is a known cause (secondary) or not (primary). This approach has stood the test of time. The American College of Rheumatology (ACR) in 1990 produced classification criteria for the major types of vasculitis and in 1994 definitions were promulgated by the Chapel Hill Consensus Conference. These did not include anti-neutrophil cytoplasm antibodies (ANCA) and the ACR scheme did not include microscopic polyangiitis. The definitions have recently been updated to include modern concepts of pathogenesis including ANCA. No validated diagnostic criteria are available for routine clinical practice. The diagnosis of vasculitis requires a high index of suspicion, especially in the systemically unwell patient with multiorgan involvement. The key to diagnosis is a detailed and systematic approach to patient assessment involving all potentially involved organs. In a patient with suspected vasculitis immediate urinalysis is mandatory as the severity of renal involvement at presentation is a major determinant of outcome. Each potentially involved organ should be comprehensively evaluated. Tissue biopsy should be obtained whenever possible, as treatment is potentially toxic using glucocorticoids combined with cytotoxic agents. Biopsy should not, however, delay initiation of treatment. Potential alternative diagnosis should be considered, especially infection and malignancy, and excluded whenever possible.

Inflammatory ulcera caused of vasculitides and vasculopathy

Phlebologie ◽  
2015 ◽  
Vol 44 (05) ◽  
pp. 261-270
Author(s):  
E. S. Kaisermayer ◽  
G. Daeschlein ◽  
M. Jünger ◽  
S. Lutze
Keyword(s):  
Differential Diagnosis ◽  
Venous Insufficiency ◽  
Arterial Disease ◽  
Lower Leg ◽  
Consensus Conference ◽  
Demographic Parameters ◽  
Chapel Hill ◽  
First Impression ◽  
Chapel Hill Consensus Conference ◽  
Peripheral Arterial

SummaryIn addition to traditional vascular causes ulceration of the lower leg as peripheral arterial disease and chronic venous insufficiency, it is primarily the vasculitis and vasculopathies, often are both diagnostically and therapeutically to a challenge.The disorder group ranked in the frequency distribution of the causes of a leg ulcer with <10 % rarely in the area, but is much more complex of the pathogenesis, the clinical picture, the course of therapy and often much more complex.The revised International in 2012 Chapel Hill Consensus Conference (CHCC) Nomenclature of vasculitis is a first impression of the diversity of this group of diseases and makes it clear how important the medical history for diagnosis is.In the CHCC- categorizing the etiology, pathogenesis, the caliber of the vessel, the inflammatory type, the organs mainly affected, the clinical manifestation, genetic predisposition and demographic parameters were included.With this revision of the first CHCC nomenclature of 1994 took place an important adaptation to the latest findings. The group of vasculitis is divided specific, this facilitates the handling of the disease in clinical practice.The vasculopathies represent another rare fringe of the causes of an ulcer curis. These disorders are often as complex as a vasculitis and must be always used in difficult to treat ulcers in the differential diagnosis.

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