Gentamicin Sulfate Ophthalmic Solution

Introduction: Polyvinyl alcohol (PVA), a polymer, is in demand due to its usage in different applications such as pharmaceutical, biomedical and textile, paper, food industries. Methods: A new sensitive reversed phased high-pressure liquid chromatography (RP-HPLC) method with refractive index detector (RID) was developed for determination of PVA in an ophthalmic solution containing dexpanthenol and PVA as active substances and it was validated according to The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) guideline. Results: Chromatographic separation was achieved on a Chiral-AGP (150 mm × 4.0 mm, 5 μm) column kept at 30°C with an isocratic flow at a flow rate of 1.0 ml/min. The detector temperature was 30°C, the retention time of PVA was around 1.0 min and the total run time was 5 minutes. Conclusion: The proposed method showed linearity, accuracy, precision, specificity, robustness, solution stability, and system suitability results within the acceptance criteria.

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A One-Week Comfort Study of BID-Dosed Brinzolamide 1%/Timolol 0.5% Ophthalmic Suspension Fixed Combination Compared to BID-Dosed Dorzolamide 2%/Timolol 0.5% Ophthalmic Solution in Patients with Open-Angle Glaucoma or Ocular Hypertension

Journal of Ocular Pharmacology and Therapeutics ◽

10.1089/jop.2008.0030 ◽

2008 ◽

Vol 24 (6) ◽

pp. 601-606 ◽

Cited By ~ 12

Author(s):

Stephen D. Vold ◽

Richard M. Evans ◽

Robert H. Stewart ◽

Thomas Walters ◽

Sushanta Mallick ◽

...

Keyword(s):

Ocular Hypertension ◽

Fixed Combination ◽

Open Angle Glaucoma ◽

Ophthalmic Solution ◽

Open Angle ◽

Ophthalmic Suspension

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Development of thermoresponsive poloxamer in situ gel loaded with gentamicin sulfate for cavity wounds

Journal of Polymer Research ◽

10.1007/s10965-020-02352-6 ◽

2021 ◽

Vol 28 (4) ◽

Author(s):

Jitti Niyompanich ◽

Piyachat Chuysinuan ◽

Prasit Pavasant ◽

Pitt Supaphol

Keyword(s):

In Situ Gel ◽

Gentamicin Sulfate

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Topical bromfenac reduces multiple inflammatory cytokines in the aqueous humour of pseudophakic patients

Scientific Reports ◽

10.1038/s41598-021-85495-w ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Takehiro Matsumura ◽

Kentaro Iwasaki ◽

Shogo Arimura ◽

Ryuji Takeda ◽

Yoshihiro Takamura ◽

...

Keyword(s):

Growth Factor ◽

Inflammatory Cytokines ◽

Aqueous Humour ◽

Ophthalmic Solution ◽

Vascular Endothelial ◽

Monocyte Chemoattractant Protein 1 ◽

Monocyte Chemoattractant ◽

Before And After ◽

Endothelial Growth Factor ◽

Single Blind

AbstractIntraocular surgery is associated with increased ocular inflammation. If maintained for a prolonged period after surgery, this inflammation can cause various complications, including subconjunctival fibrosis and bleb scarring. This clinical trial was a prospective, randomised, single-blind, interventional study comparing the efficacy and safety of 0.1% bromfenac sodium ophthalmic solution and 0.02% fluorometholone ophthalmic suspension in the inhibition of multiple inflammatory cytokines in the aqueous humour of 26 patients with pseudophakic eyes who had undergone phacoemulsification and intraocular lens implantation. The patients were randomly assigned to one of the trial drugs, and aqueous humour samples were collected before and after drug administration. Platelet-derived growth factor-AA levels significantly decreased in both drug groups, but they were significantly higher in the fluorometholone group than in the bromfenac group (P = 0.034). Bromfenac also significantly decreased vascular endothelial growth factor level (P = 0.0077), as well as monocyte chemoattractant protein-1 level (P = 0.013), which was elevated for a prolonged period after phacoemulsification. These data suggest that bromfenac is useful to alleviate prolonged microenvironmental alterations in the aqueous humour of pseudophakic eyes.

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