Family Tree for Aqueous Organic Redox Couples for Redox Flow Battery Electrolytes: A Conceptual Review

Redox flow batteries (RFBs) are an increasingly attractive option for renewable energy storage, thus providing flexibility for the supply of electrical energy. In recent years, research in this type of battery storage has been shifted from metal-ion based electrolytes to soluble organic redox-active compounds. Aqueous-based organic electrolytes are considered as more promising electrolytes to achieve “green”, safe, and low-cost energy storage. Many organic compounds and their derivatives have recently been intensively examined for application to redox flow batteries. This work presents an up-to-date overview of the redox organic compound groups tested for application in aqueous RFB. In the initial part, the most relevant requirements for technical electrolytes are described and discussed. The importance of supporting electrolytes selection, the limits for the aqueous system, and potential synthetic strategies for redox molecules are highlighted. The different organic redox couples described in the literature are grouped in a “family tree” for organic redox couples. This article is designed to be an introduction to the field of organic redox flow batteries and aims to provide an overview of current achievements as well as helping synthetic chemists to understand the basic concepts of the technical requirements for next-generation energy storage materials.

Development and Validation of an Analytical HPLC Method to Assess Chemical and Radiochemical Purity of [68Ga]Ga-NODAGA-Exendin-4 Produced by a Fully Automated Method

Background: Glucagon-like peptide 1 receptor (GLP-1R) is preferentially expressed in pancreatic islets, especially in β-cells, and highly expressed in human insulinomas and gastrinomas. In recent years several GLP-1R–avid radioligands have been developed to image insulin-secreting tumors or to provide a tentative quantitative in vivo biomarker of pancreatic β-cell mass. Exendin-4, a 39-amino acid peptide with high binding affinity to GLP-1R, has been labeled with Ga-68 for imaging with positron emission tomography (PET). Preparation conditions may influence the quality and in vivo behavior of tracers. Starting from a published synthesis and quality controls (QCs) procedure, we have developed and validated a new rapid and simple UV-Radio-HPLC method to test the chemical and radiochemical purity of [68Ga]Ga-NODAGA-exendin-4, to be used in the clinical routine. Methods: Ga-68 was obtained from a 68Ge/68Ga Generator (GalliaPharma®) and purified using a cationic-exchange cartridge on an automated synthesis module (Scintomics GRP®). NODAGA-exendin-4 contained in the reactor (10 µg) was reconstituted with HEPES and ascorbic acid. The reaction mixture was incubated at 100 °C. The product was purified through HLB cartridge, diluted, and sterilized. To validate the proposed UV-Radio-HPLC method, a stepwise approach was used, as defined in the guidance document released by the International Conference on Harmonization of Technical Requirements of Pharmaceuticals for Human Use (ICH), adopted by the European Medicines Agency (CMP/ICH/381/95 2014). The assessed parameters are specificity, linearity, precision (repeatability), accuracy, and limit of quantification. Therefore, a range of concentrations of Ga-NODAGA-exendin-4, NODAGA-exendin-4 (5, 4, 3.125, 1.25, 1, and 0.75 μg/mL) and [68Ga]Ga-NODAGA-exendin-4 were analyzed. To validate the entire production process, three consecutive batches of [68Ga]Ga-NODAGA-exendin-4 were tested. Results: Excellent linearity was found between 5–0.75 μg/mL for both the analytes (NODAGA-exendin-4 and 68Ga-NODAGA-exendin-4), with a correlation coefficient (R2) for calibration curves equal to 0.999, average coefficients of variation (CV%) <2% (0.45% and 0.39%) and average per cent deviation value of bias from 100%, of 0.06% and 0.04%, respectively. The calibration curve for the determination of [68Ga]Ga-NODAGA-exendin-4 was linear with a R2 of 0.993 and CV% <2% (1.97%), in accordance to acceptance criteria. The intra-day and inter-day precision of our method was statistically confirmed using 10 μg of peptide. The mean radiochemical yield was 45 ± 2.4% in all the three validation batches of [68Ga]Ga-NODAGA-exendin-4. The radiochemical purity of [68Ga]Ga-NODAGA-exendin-4 was >95% (97.05%, 95.75% and 96.15%) in all the three batches. Conclusions: The developed UV-Radio-HPLC method to assess the radiochemical and chemical purity of [68Ga]Ga-NODAGA-exendin-4 is rapid, accurate and reproducible like its fully automated production. It allows the routine use of this PET tracer as a diagnostic tool for PET imaging of GLP-1R expression in vivo, ensuring patient safety.

Single Reflect-Mirror Laser Communication Tracking-Pointing System Load Technology for Micronanosatellite

In order to realize low-orbit microsatellite laser communication, L- and U-frame structures are designed, respectively, for the payload of single-lens reflex (SLR) laser communication tracking and pointing system. According to the characteristics of each load structure, the detailed system design is carried out, and the modal analysis is carried out on the key structural parts of the L- and U-frames to ensure the reliability of each load structure. The pointing accuracy of the two load structures is also calculated and analyzed. Finally, the conclusion is that both of the two load structures can meet the technical and accuracy requirements of low-orbit communication, but obviously, the U-frame structure has higher accuracy, greater pitching angle, and better reliability; eventually, the U-frame structure is adopted in this design. Then, we have completed the manufacture and assembly of the principle prototype and carried out a vibration test experiment on the principle prototype. The results show that the U-type loading structure SLR laser communication tracking and pointing system achieves the expected design purpose and can meet the technical requirements of the low-orbit microsatellite laser communication.

Printing and Publishing of Music

This article covers the dissemination of musical scores by technical means. The function of both printing and publication is to produce multiple copies of a work or a group of works and to arrange for the distribution of those copies to many purchasers. This requires diverse skills: on the one hand, the ability to print, involving preparing a copy of the music in a form suitable for the printing press, and then producing the copies; on the other, to make marketing decisions, to handle advertising and distribution of copies to individuals or to music shops, and to budget and plan for profits. Since the first printed music produced by Ottaviano Petrucci at the beginning of the 16th century, printing has been developed in Europe on a broad scale. Its technical requirements have changed from movable type to engraving, lithography, and, most recently, the computer. Entries are arranged to cover these activities separately, and then provide an introduction to bibliography, the scholarly study of both activities. Descriptive bibliography and analytic bibliography are recent in the field of music; they have been primarily devoted to the study of the printers and publishers from the 16th to the 18th centuries established in the main centers in Europe, including Venice, Paris, Antwerp, Frankfurt, London, and Vienna. Specific topics have become of increasing interest in recent years, including patterns of distributing copies and reaching markets and music appearing in general cultural periodicals and magazines. In addition, two subjects have risen to importance, the first, the paratext, or matters of design, which is sparsely discussed in connection with music; and the second, the place of music and its editions in cultural and intellectual history. Use of printed music has changed during the 20th century. Employed as a mean for performing and circulating music among musicians, professionals, and amateurs during four centuries, printed music became a support to produce performing rights when audiovisual media became the main access to music. Another important evolution has been the production of different kind of editions. During a long period, publishers sold the music written day by day for the entertainment of specific groups in society and for a specific purpose—liturgy, concert life, house music. Following a growing interest in the music of the past, they began to produce collected works and critical editions that reconcile mass production to the quality of the publishing.

Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product

The work mainly focused on a validation of the method for determining the content of salicylic acid and individual unknown impurities in new pharmaceutical product—tablets containing: 75, 100 or 150 mg of acetylsalicylic acid and glycine in the amount of 40 mg for each dosage. The separation of the components was carried out by means of HPLC, using a Waters Symmetry C18 column (4.6 × 250 mm, 5 μm) as the stationary phase. The mobile phase consisted of a mixture of 85% orthophosphoric acid, acetonitrile and purified water (2:400:600 V/V/V). Detection was carried out at a wavelength of 237 nm, with a constant flow rate of 1.0 ml min−1. In order to verify the method, linearity, precision (repeatability and reproducibility), accuracy, specificity, range, robustness, system precision, stability of the test and standard solution, limit of quantification and forced degradation were determined. Validation tests were performed in accordance with ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guidelines. The method was validated successfully. It was confirmed that the method in a tested range of 0.005–0.40% salicylic acid with respect to acetylsalicylic acid content is linear, precise and accurate.

APPLICATION OF HOUSE OF QUALITY IN THE CONCEPTUAL DESIGN OF BATIK WAX EXTRUDER AND PRINTER

Malaysian batik production is dominated by two techniques known as hand-drawn batik, or batik tjanting, and stamp batik, or batik block. In comparison to batik block, the more popular batik tjanting takes a longer time to produce. A Standardized Nordic Questionnaire (SNQ) for musculoskeletal symptom examination involving batik artisans in Kelantan and Terengganu identified high rates of musculoskeletal disorders in respondents due to their working posture during the batik tjanting process. It was also observed that the number of workers and artisans willing to participate in the traditional batik industry is on the decline. These problems have led to a systematic Quality Functional Deployment approach to facilitate the decision-making process for the conceptual design of an automatic batik printer. In this study, house of quality (HOQ) was applied to identify the critical features for a batik printer based on the voice of the customer (VOC). A survey done to rate the importance of VOC using an 8-point Likert scale revealed that the batik practitioners topmost priority for the batik printer feature is the 'ability to adjust and maintain the temperature of wax' (17.54%) while the non-batik practitioners chose 'ability to deliver a variety of complex designs' (15.94%). The least required feature for the batik printer was related to the size of the batik printer. The mapping between customer requirements (VOC) and technical requirements identified that the extruder design (21.3%), the heating element (18%), and nozzle diameter (17.8%) were the most critical components for the batik printer. Several conceptual designs of the extrusion unit, cartesian-based batik printer, and 2D image conversion using open-sourced software were proposed at the end of this work. ABSTRAK: Pengeluaran batik Malaysia telah didominasi oleh dua teknik yang dikenali sebagai batik lukisan-tangan (batik canting) dan batik cap (batik blok). Sebagai perbandingan, batik canting yang popular mengambil masa lebih lama bagi dihasilkan. Soal Selidik Nordic Standad (SNQ) bagi meneliti gejala muskuloskeletal melibatkan tukang batik di Kelantan dan Terengganu telah menunjukkan persamaan kadar muskuloskeletal yang tinggi pada postur badan semasa bekerja canting batik. Bilangan pekerja yang terlibat dalam industri tradisional batik ini turut terjejas. Masalah-masalah ini telah mengarah kepada kaedah Pengerahan Fungsi Kualiti bagi membantu proses membuat keputusan dalam rekaan konsep pencetak batik automatik. Kajian ini telah mengadaptasi Kualiti Rumah (HOQ) bagi mengesan ciri-ciri kritikal pada pencetak batik berdasarkan suara pelanggan (VOC). Kaji selidik telah dilakukan bagi menilai kepentingan VOC menggunakan skala Likert 8-poin. Didapati keutamaan yang diperlukan oleh 17.54% ahli batik adalah; ciri pencetak batik ini perlu mempunyai ‘keupayaan dalam menyelaras dan menetapkan suhu lilin’, manakala sebanyak 15.94% bukan ahli batik memilih ‘keupayaan pencetak ini harus berjaya menghasilkan pelbagai rekaan yang kompleks’. Ciri yang kurang diberi tumpuan adalah berkaitan saiz pencetak batik. Persamaan antara kehendak pelanggan (VOC) dan kehendak teknikal dalam mengenal pasti komponen-komponen penting bagi pencetak batik adalah rekaan penyemperit (21.3%), elemen pemanas (18%), dan diameter nozel (17.8%). Pelbagai rekaan konsep bagi unit penyemperit, pencetak batik canting, dan imej konversi 2D menggunakan perisian sumber terbuka telah dicadangkan di bahagian akhir kajian ini.

Are Family Businesses a Good Environment for Project Management?

Relationships between project management, operations management, and organizational strategy are well-known, as well as organizational influences on project. Family businesses work on projects, but their unique nature makes family firms a challenging context for Project Management. This chapter aims to present and discuss the specific dynamics of family business that can impact project management practices. By definition, a project is a complex system, consisting of a set of dozens of interrelated sub-processes. As is known, the percentage of projects that satisfy both technical requirements, budget compliance and which meet the deadlines, is extremely low. This fact forces the researchers to equip themselves with more sophisticated tools to face the complexity of a project, in order to increase its chances of success.