Thiamine Hydrochloride Tablets

2001 ◽  
Vol 63 (4) ◽  
pp. 338-342 ◽  
Author(s):  
Michael E. Barnes ◽  
Michael H. Zehfus ◽  
Jonathan A. Schumacher ◽  
Kelly S. Stock ◽  
Faraz Farrokhi ◽  
...  

1979 ◽  
Vol 35 (2) ◽  
pp. 249-250 ◽  
Author(s):  
S. Das Gupta ◽  
M. V. Moorthy ◽  
B. L. Chowdhri ◽  
A. K. Ghosh

2018 ◽  
Vol 192 ◽  
pp. 03032
Author(s):  
Okti Herliana ◽  
A. H. Saeful Anwar ◽  
Ida Widiyawati

This study aimed to investigate the influence of organic fertilizers and seedling numbers each holes of black rice on yield, antioxidant, amylum, and thiamin hydroclorine contents, and to observe the interaction effect between types of organic fertilizers and seedling numbers each hole planting. This study was conducted on rice field in Karanglewas Kidul Village, Karanglewas, Banyumas Regency, Central Java from April until September 2016. The location altitude in this study for about 93 meters above the sea level. The study was arranged by Split Plot Design by the main plot consist with three types of organic fertilizers that was chicken, goat, and cow manures, and the sub plot was consists by seedling number were, three, two, and one seedling by each holes, with three replicates of each combination treatments. The result showed that chicken manure treatment provide the best influences on grain weight per hectare by 5.154 tons, amylum content by 33.86%, anthocyanin content by 275.40 ppm, and Thiamin hydrocloride content by 0.056 mg/10g. The three seedling each hole provide the best influences on amylum content by 33.78%, anthocyanin content by 275.18 ppm, and thiamine hydrochloride content by 0.058 mg/10g.


Author(s):  
Ilma Nugrahani ◽  
Citra Kartini

<p><strong>Objective: </strong>The combination of thiamine hydrochloride (vitamin B1) with pyridoxine hydrochloride (vitamin B6) has been efficacious to help the metabolism of carbohydrates and amino acids. FTIR (Fourier transform infrared) is a technique widely used in compound identification and determination of functional groups but rarely used for the quantitative purposes. This study aims to obtain a analysis determination method of this vitamin combination simultaneously in tablet dosage form using FTIR.</p><p><strong>Methods: </strong>Amount of vitamin B1 and B6 standard were mixed with KBr crystal in a series of concentration (% w/w) in kalium bromide (kbr) crystal, then measured with FTIR. These spectrums yielded were transformed into an absorbance afterward changed to its derivative. The finest spectrum, which showed the best specificity and linearity, was selected and its area under the curve was calculated. The other validation parameters: accuracy, precision, detection limit, quantitation limit, and ranges, next were tested and determined. The validated method than was used to analyze the levels of vitamin B1 and B6 simultaneously in the tablets.</p><p><strong>Results: </strong>Vitamin B1 and B6 have the linear concentration range from 0.5 to 3.00% w/w. The regression equation for vitamin B1 is y = 0.0608 x-0.0176 with r = 0.9997 and Vx0 = 1.5047%, for vitamin B6: y = 0.0977 x+0.0079 r = 0.9995 and Vx0 = 1.7832%. Recovery results of vitamin B1: 98.98 to 100.93%, while B6: 99.06 to 100.43%. Intra-day and inter-day precision for vitamin B1: 1.73; 1.62; 1.48, and 0.58%, meanwhile for vitamin B6: 1.29; 1.60; 1.78, and 1.39%. The limits of detection and quantitation for vitamin B12 was 0.079 and 0.263% w/w respectively, and for vitamin B6, was: 0.093 and 0.311% w/w. The tablets from the market were tested showed the results that meet with compendia requirements.</p><p><strong>Conclusion: </strong>FTIR can be used for the determination of levels of vitamin B1 and B6 simultaneously in tablet dosage form and have met the validation requirements.</p>


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