Sodium Taurodeoxycholate

Solid Lipid Nanoparticles (SLN) containing Methotrexate (MTX), an anticancer drug for intravenous administration was formulated and characterized. The SLN dispersions with MTX, stearic acid, and soya lecithin in the ratio of 1:4:1, 1:4:1.5, and 1:4:2, sodium taurodeoxycholate and distilled water were prepared by micro emulsification solidification method. The results show that the prepared MTX-SLN particles (with MTX–Stearic acid–Soya lecithin—1:4:2) have an average size of 270 nm with 51.3% drug entrapment. The in vitro-release was attained up to 15th h. The pharmacokinetic studyreveals that the half-life and MRT of SLNs were higher than MTX solution. The life span of EAC (Ehrlich Ascite Carcinoma) bearing mice was increased when treated with MTX-SLNs (Methotrexate nanoparticles). These results clearly indicate that SLNs are a promising sustained release drug targeting system for lipophilic antitumour drugs.

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MUCOSAL INJURY: THE COMBINED EFFECTS OF LYSOPHOSPHATIDYLCHOLINE AND SODIUM TAURODEOXYCHOLATE ON THE RAT STOMACH

Journal of Pharmacy and Pharmacology ◽

10.1111/j.2042-7158.1985.tb14214.x ◽

1985 ◽

Vol 37 (S12) ◽

pp. 144P-144P ◽

Cited By ~ 2

Author(s):

R.S. Newbery ◽

G.P. Martin ◽

N.C. Turner ◽

C. Marriott

Keyword(s):

Mucosal Injury ◽

Combined Effects ◽

Rat Stomach ◽

Sodium Taurodeoxycholate

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Aggregation Dynamics of Sodium Taurodeoxycholate and Sodium Deoxycholate

Langmuir ◽

10.1021/la9903705 ◽

2000 ◽

Vol 16 (4) ◽

pp. 2038-2041 ◽

Cited By ~ 13

Author(s):

Y. Li ◽

J. F. Holzwarth ◽

C. Bohne

Keyword(s):

Sodium Deoxycholate ◽

Sodium Taurodeoxycholate

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Phase equilibria of the mixed didodecyldimethylammonium bromide–sodium taurodeoxycholate–water system with a large solution region

Colloids and Surfaces A Physicochemical and Engineering Aspects ◽

10.1016/j.colsurfa.2005.06.066 ◽

2005 ◽

Vol 269 (1-3) ◽

pp. 87-95 ◽

Cited By ~ 7

Author(s):

Malin Bydén Sjöbom ◽

Eduardo F. Marques ◽

Håkan Edlund ◽

Ali Khan

Keyword(s):

Phase Equilibria ◽

Water System ◽

Large Solution ◽

Didodecyldimethylammonium Bromide ◽

Sodium Taurodeoxycholate ◽

Solution Region

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Excystation of Isospora brachyrhynchi Cawthorn and Wobeser, 1985 in vitro

Canadian Journal of Zoology ◽

10.1139/z85-395 ◽

1985 ◽

Vol 63 (11) ◽

pp. 2646-2648 ◽

Cited By ~ 1

Author(s):

P. H. G. Stockdale ◽

Anne Sheard ◽

R. J. Cawthorn

Keyword(s):

Bile Salts ◽

Potassium Dichromate ◽

Taurocholic Acid ◽

Sodium Glycocholate ◽

Different Temperatures ◽

Sodium Taurodeoxycholate

Oocysts of Isospora brachyrhynchi Cawthorn and Wobeser, 1985 were recovered from feces of experimentally infected juvenile crows (Corvus brachyrhynchus) and stored for up to 12 months in a 2.5% (w/v) solution of potassium dichromate at 4 °C. Sporocysts were released from the oocysts by grinding in a homogenizer. Various bile salts, taurocholic acid, pooled chicken bile, sodium glycocholate, and sodium taurodeoxycholate were used in conjunction with trypsin as media to excyst sporozoites of I. brachyrhynchi. These media were tested at different temperatures and on oocysts stored for varying lengths of time. The most effective excystation (94%) was seen in oocysts that had been stored for 1 month and were incubated with 5.0% sodium taurodeoxycholate and 0.25% trypsin at 41 °C for 60 min. Varying degrees of excystation were observed using different bile salts at different temperatures on oocysts stored for up to 12 months.

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