PROPERTIES OF ALBENDAZOLE SOLID DISPERSIONS OBTAINED BY MECHANOCHEMICAL MODIFICATION WITH POLYMERS
Given the potential for using methods of mechanochemical modification of difficultly soluble substances of drugs using water soluble polymers of synthetic and natural origin, we conducted studies to improve the solubility of the anthelmintic substance of albendazole (ABZ) by coprocessing ABZ with polymers chitosan and PVP. In this case, solid dispersions (SD) of the ABZ compositions – chitosan = 1:9 and ABZ : PVP = 1:9 – were obtained, which were easy loose powders that formed stable suspension concentrates suitable for the use on animals. Moreover, the solubility of ABZ in these SDs was 20 and 27 times higher respectively than that of the initial substance. When studying the anthelmintic activity of the obtained SDs against the causative agents of fascioliasis, monieziasis, marshallagiasis, nematodirosis and other gastrointestinal strongylatoses in sheep, their high efficiency was established. Thus, if before ABZ : chitosan = 1: 9 was used, sheep were infected with Marshallagia at 88.8%, Nematodirus at 58.0%, and other gastrointestinal strongylates (Ostertagia, Trychostrongilus, etc.) at 80.6%, Fasciola at 96.7%, Moniezia at 6.4%, and the total invasion rate was 96.7%, the prevalence (EI) of these helminths amounted to 58.0%, 3.2%, 9.6%, 5.8%, 0% and 83.8% respectively after 5 days following the use of the drug. When testing the drug composition ABZ : PVP = 1:9 on sheep infected with Marshallagia at 88.8%, Nematodirus at 66.6%, other gastrointestinal strongylates at 72.2%, Fasciola at 24.0%, Moniezia at 5.5%, and all helminths at 100%, decrease in the invasion was observed to 50.0%, 0%, 5.5%, 27.7%, 0% and 50.0% respectively. These experimental data allowed the authors to recommend the ABZ-based drugs for practical use.