The Fourth International School of Young Scientists on Molecular Genetics on the Topic “Genomics and Cell Biology”

2011 ◽  
Vol 26 (2) ◽  
pp. 87-91
Author(s):  
S. A. Limborska
Author(s):  
W. Bernard

In comparison to many other fields of ultrastructural research in Cell Biology, the successful exploration of genes and gene activity with the electron microscope in higher organisms is a late conquest. Nucleic acid molecules of Prokaryotes could be successfully visualized already since the early sixties, thanks to the Kleinschmidt spreading technique - and much basic information was obtained concerning the shape, length, molecular weight of viral, mitochondrial and chloroplast nucleic acid. Later, additonal methods revealed denaturation profiles, distinction between single and double strandedness and the use of heteroduplexes-led to gene mapping of relatively simple systems carried out in close connection with other methods of molecular genetics.


2000 ◽  
pp. 143-167 ◽  
Author(s):  
David S. Roos ◽  
John A. Darling ◽  
Mary G. Reynolds ◽  
Kristin M. Hager ◽  
Boris Striepen ◽  
...  

Parasitology ◽  
1989 ◽  
Vol 98 (S1) ◽  
pp. S19-S28 ◽  
Author(s):  
G. F. Mitchell

AbstractThe modern biology era in which molecular analyses dominate and immunology, cell biology and molecular genetics are prominent, has created unprecedented opportunities for the vaccine developer. The need for new and improved vaccines against many infectious disease agents is also great, no more so than for the protozoan and helminth parasite scourges of the rural poor in the tropical, less-industrially developed world. Despite the opportunities and needs, no vaccine against any human parasite yet exists nor does any molecular vaccine against any parasite; this chapter is a general discussion on the reasons for this state of affairs that assuredly will change soon.


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