scholarly journals A REVIEW ON SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG USING NATURAL CARRIER

2021 ◽  
Vol 10 (10) ◽  
Keyword(s):  
Solubility Enhancement ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

scholarly journals Solubility Enhancement of Nicergoline Poorly Water Soluble Drug by Novel Melt Sonocrystallization Technique

2020 ◽  
Vol 9 (12) ◽  
pp. 347-365
Author(s):  
  Akshay Agarwal ◽  
Aman Mittal ◽  
Sayed Ikram ◽  
Dr. Lalit Tyagi ◽  
Dr. Chitra Gupta
Keyword(s):  
Solubility Enhancement ◽  
Water Soluble ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

SOLUBILITY ENHANCEMENT OF OFLOXACIN BY MIXED SOLVENCY APPROACH

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (06) ◽  
pp. 34-40
Author(s):  
D. D Gadade ◽  
◽  
T. S Lohade ◽  
S. R. Lahoti ◽  
S. S. Rawat ◽  
...  
Keyword(s):  
Sodium Acetate ◽  
Sodium Citrate ◽  
Antimicrobial Properties ◽  
Solubility Enhancement ◽  
Water Soluble ◽  
Peg 400 ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Antimicrobial Effectiveness ◽  
Poorly Water Soluble Drug

In current study we attempted mixed solvency approach for solubility enhancement of poorly water soluble drug, ofloxacin. Various hydrotropic agents including sodium benzoate, urea, sodium citrate, sodium acetate, niaciniamide, Lignocaine hydrochloride, PEG6000, PEG-400 were evaluated under study for enhancing solubility of drug. Further effect of various blends of these hydrotropic agents on solubility of ofloxacin was studied. Aqueous injection of ofloxacin was prepared and evaluated for its antimicrobial effectiveness and stability. It was found that mixed solvency approach is useful in solubility enhancement of ofloxacin without affecting its antimicrobial properties.

NANO-SIZED SOLID DISPERSION OF A POORLY WATER-SOLUBLE DRUG

2012 ◽  
pp. 31-35
Author(s):  
Truong Dinh Thao Tran ◽  
Ha Lien Phuong Tran ◽  
Nghia Khanh Tran ◽  
Van Toi Vo
Keyword(s):  
Drug Release ◽  
Droplet Size ◽  
Solid Dispersion ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Dissolution Enhancement ◽  
Particle Size Reduction ◽  
Water Soluble Drug ◽  
Poorly Water Soluble ◽  
Poorly Water Soluble Drug

Purposes: Aims of this study are dissolution enhancement of a poorly water-soluble drug by nano-sized solid dispersion and investigation of machenism of drug release from the solid dispersion. A drug for osteoporosis treatment was used as the model drug in the study. Methods: melting method was used to prepare the solid dispersion. Drug dissolution rate was investigated at pH 1.2 and pH 6.8. Drug crystallinity was studied using differential scanning calorimetric and powder X-ray diffraction. In addition, droplet size and contact angle of drug were determined to elucidate mechanism of drug release. Results: Drug dissolution from the solid dispersion was significantly increased at pH 1.2 and pH 6.8 as compared to pure drug. Drug crystallinity was changed to partially amorphous. Also dissolution enhancement of drug was due to the improved wettability. The droplet size of drug was in the scale of nano-size when solid dispersion was dispersed in dissolution media. Conclusions: nano-sized solid dispersion in this research was a successful preparation to enhance bioavailability of a poorly water-soluble drug by mechanisms of crystal changes, particle size reduction and increase of wet property.

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