Cytotoxic effect of hydroalcoholic extract of Cota tinctoria (L.) J.Gay on AGS and Hep-G2 cancer cell lines

Cota tinctoria is a medicinal plant which has been used for management of cancer in folk medicine of various regions. The aim of present study is to investigate cytotoxic activity of different concentrations of hydroalcoholic extract of C. tinctoria flowers on gastric (AGS) and liver (Hep-G2) cancer cell lines as well as Human Natural GUM fibroblast (HUGU) cells. Cell mortality rates were examined after 24, 48 and 72 h incubations using the MTT assay. IC50 of extract on AGS cells after 24, 48 and 72h was 1.46, 1.29 and 1.14 µg/mL respectively. The extract demonstrated IC50 of 5.15, 3.92 and 2.89 µg/mL on Hep-G2 cells after 24, 48 and 72 h respectively. No cytotoxic effect was detected on HUGU (Human Natural GUM fibroblast) cells. C. tinctoria seems to have a promising potential to be considered as a source for anticancer drug discovery. However, more experimental and clinical studies are required.

Beneficiation of Commiphora africana Plant: Extraction and Application of Green Softener on Cotton Fabric

This paper aims at the extraction and application of eco- and user-friendly natural gum obtained from Commiphora Africana tree. The result obtained is also compared with fabric treated with a commercial softener of the same concentration. The gum was extracted by puncturing the stem of the plant and the extracted gum was applied directly to 100% cotton fabric through a padding process with different concentrations of extracted gum (i.e., 20 gram per litre (g/l), 25 g/l, and 30 g/l). Another similar fabric sample was treated with a silicon softener of the same concentration. The fabric samples treated with both natural gum and silicon softener were tested for their stiffness, crease recovery, and drapability. The results show that the change in fabric softness depends on the concentration of softener used in both cases. As the concentration of the softener increased, there was a decrease in bending length and drape coefficient for both fabric samples. The drape coefficient of fabric sample treated with natural gum has a comparable result with fabric treated with silicon/commercial softener. Maximum increases in recovery angle were seen in fabric treated with natural gum at a concentration of 30 g/l.

Pharmacological Importance of Peach Gum Polysaccharide: A Review

Background: Peach gum is a natural gum exudate secreted from a peach tree (Prunus persica) from a process known as physiological gummosis. Peach gum is a natural biopolymer that is composed of acidic polysaccharides with a high percentage of arabinose and galactose subunit, which classifies it as an arabinogalactan. Objectives: This review summarizes the compositions, chemical structures, physical properties, biological properties of peach gum, and its potential biotechnological applications. Method: Literature search was performed using Google Scholar using keywords such as Peach Gum, Prunus persica. Only articles written in English and articles with downloadable full-texts were included in this review. Results: Peach gum polysaccharides possess antibacterial, antioxidant and anti-diabetic, and hypolipidemic properties. Excellent emulsification properties of PGP show it has potential to be employed as a food-grade emulsifier. Conclusion: PGP exhibits excellent emulsification, antioxidant, antibacterial, anti-diabetic and hypolipidemic properties. As plastic pollution has become an alarming global issue, PGP could be a promising edible raw material in the field of bioplastic research and development.

A Review of Gum Hydrocolloid Polyelectrolyte Complexes (PEC) for Biomedical Applications: Their Properties and Drug Delivery Studies

The utilization of natural gum polysaccharides as the vehicle for drug delivery systems and other biomedical applications has increased in recent decades. Their biocompatibility, biodegradability, and price are much cheaper than other materials. It is also renewable and available in massive amounts, which are the main reasons for its use in pharmaceutical applications. Gum can be easily functionalized with other natural polymers to enhance their applications. Various aspects of the utilization of natural gums in the forms of polyelectrolyte complexes (PECs) for drug delivery systems are discussed in this review. The application of different mathematical models were used to represent the drug release mechanisms from PECs; these models include a zero-order equation, first-order equation, Higuchi, simplified Higuchi, Korsmeyer–Peppas, and Peppas–Sahlin.

FORMULATION AND EVALUATION OF BUDESONIDE PELLETS CONTAINING NATURAL GUMS FOR COLON TARGETING

Pellets formulation with natural gums. The formulation of an enzyme as well as pH dependant pellets containing natural gums such as Mornings oleifera gum Lam. (MOG) and Cyamopsis tetragonolobus gum Taub. (CTG) were used for enzyme dependant release and further coating is provided to shows colon-specific delivery. Extrusion and spheronization techniques were used for the preparation of pellets. Pellets of budesonide evaluated for various properties such as flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability also investigated in vitro and in vivo targeting in rabbit. Preparation of pellets was done by using extrusion and spheronization method with the use of optimized concentration of gums those were 7.5% and 10% for CTG and MOG respectively and proportion of solvent mixture of water and Isopropyl alcohol in the ratio of 80:20. Pellets of budesonide evaluated for various properties includes flow behavior, physical properties such as sphericity, roundness, aspect ratio, hardness, and friability and found that all properties as per official limit also in vitro release study found that release of uncoated pellets in a sustained manner in 0.1N HCl for 2h due to swelling of natural gum, therefore further step of the coating was done in fluidized bed coater to prevent the release of drug in the upper part of GIT and after coating found that In vitro release of drug at the colonic environment and it confirmed with in vivo investigation in rabbit with X-ray examination of targeting and found that pellets reach at colonic part without disintegration. The use of natural gums for preparation of pellets in optimized concentration and wetting agent produce a formulation with all required chemical and physical properties and it gives effective in vitro release and also shows In vivo targeting in rabbit and due to use of natural gum for preparation of pellets also reduce some problems of metabolism of synthetic excipients.