A Study of Neurotransmitters in Human Inner Ear: Preservation of Human Temporal Bone and Value of Organ Donation for Inner Ear Research

1994 ◽  
Vol 114 (3) ◽  
pp. 245-253 ◽  
Author(s):  
Wei-Jia Kong ◽  
Gisela Egg ◽  
Burkhard Hussl ◽  
Michaela Seyr ◽  
Anneliese Schrott-fischer
2016 ◽  
Vol 1 (6) ◽  
pp. 126
Author(s):  
Jeļena Šaboviča ◽  
Renāta Klagiša

<p>Otosclerosis is a primary osteodystrophy which affects a localized area within the human temporal bone. Hearing loss is the most functional deficit caused by otosclerosis. However, tinnitus is frequently reported by otosclerotic patients, especially in those patients with inner ear involvement. The best therapy in achieving a significant improvement is surgery - stapedoplasty. Analysis of early hearing results (1 month after surgery) shows efficiency of surgical treatment and improvement in hearing.</p>


2018 ◽  
Vol 123 (3) ◽  
pp. 131-142 ◽  
Author(s):  
Xueshuang Mei ◽  
Francesca Atturo ◽  
Karin Wadin ◽  
Sune Larsson ◽  
Sumit Agrawal ◽  
...  

2011 ◽  
Vol 33 (10) ◽  
pp. E124-E128 ◽  
Author(s):  
D. Kolditz ◽  
T. Struffert ◽  
Y. Kyriakou ◽  
A. Bozzato ◽  
A. Dörfler ◽  
...  

2002 ◽  
Vol 116 (4) ◽  
pp. 256-260 ◽  
Author(s):  
Shinichi Nishimura ◽  
Kimitaka Kaga ◽  
Toshihiro Tsuzuku ◽  
Yukiko Iino

Four cases (seven ears) of metastatic tumour of the internal auditory canal were studied. The histopathological findings confirmed that the inner ear invasion of the tumour follows a unique course, as reported in the literature. Relationship between duration of deafness and extent of tumour invasion in the inner ear is discussed. It is suggested that the deafness could occur via neural invasion or compression near the ductus spiralis foraminosus.


2007 ◽  
Vol 121 (11) ◽  
pp. 1025-1028 ◽  
Author(s):  
M Suzuki ◽  
A Hagiwara ◽  
Y Ogawa ◽  
H Ono

AbstractPurpose:This study aimed to investigate the validity of adjusting computed tomography thresholds in order to replicate a temporal bone model suitable for dissection training and education.Materials and methods:A simulated three-dimensional model of a human temporal bone was prototyped using selective laser sintering. The powder layers were laser-fused, based on detailed computed tomography data, and accumulated to create a three-dimensional structure. The computed tomography threshold value of the stapes was modified on standard triangular language file in order to replicate the stapes. The intensity value was determined to select the fluid lumen of the inner ear and the bone surface, in order to replicate the inner ear.Results:The model could be shaved, using surgical instruments, in the same manner as during real surgery. The stapes could be reproduced, making this model even more realistic than a previous version. The inner ear was recreated, along with the surrounding bony wall and the ossicles.Conclusion:This model facilitates dissection training and easy understanding of the relation between the labyrinth and the surrounding structures.


Author(s):  
Robert W. Baloh

Like Joseph Toynbee, Harold Schuknecht believed that the only way to develop rational treatments for inner ear diseases was to understand the pathology of these diseases. Schuknecht used his human temporal bone studies to “refute the conceptual validity of several popular otologic therapies.” Probably the most controversial of these was the treatment of Ménière’s disease with endolymphatic shunt surgery. Schuknecht argued the concept that the endolymph sac can be drained to relieve endolymphatic hydrops is a pedantic notion at best. He studied numerous human temporal bone specimens of patients who had had shunts placed in the endolymphatic sac, and in every case the shunt devices were ensheathed in fibrous tissue. He debunked many other controversial treatments in otolaryngology. He argued that most cases of sudden deafness and acute vertigo (vestibular neuritis) were due to viral infections of the inner ear and eighth nerve, and that vascular treatments were inappropriate.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. A. Neves ◽  
E. D. Tran ◽  
I. M. Kessler ◽  
N. H. Blevins

AbstractMiddle- and inner-ear surgery is a vital treatment option in hearing loss, infections, and tumors of the lateral skull base. Segmentation of otologic structures from computed tomography (CT) has many potential applications for improving surgical planning but can be an arduous and time-consuming task. We propose an end-to-end solution for the automated segmentation of temporal bone CT using convolutional neural networks (CNN). Using 150 manually segmented CT scans, a comparison of 3 CNN models (AH-Net, U-Net, ResNet) was conducted to compare Dice coefficient, Hausdorff distance, and speed of segmentation of the inner ear, ossicles, facial nerve and sigmoid sinus. Using AH-Net, the Dice coefficient was 0.91 for the inner ear; 0.85 for the ossicles; 0.75 for the facial nerve; and 0.86 for the sigmoid sinus. The average Hausdorff distance was 0.25, 0.21, 0.24 and 0.45 mm, respectively. Blinded experts assessed the accuracy of both techniques, and there was no statistical difference between the ratings for the two methods (p = 0.93). Objective and subjective assessment confirm good correlation between automated segmentation of otologic structures and manual segmentation performed by a specialist. This end-to-end automated segmentation pipeline can help to advance the systematic application of augmented reality, simulation, and automation in otologic procedures.


2020 ◽  
Vol 53 (2) ◽  
pp. 16424-16429
Author(s):  
Milka C.I. Madahana ◽  
Otis T.C. Nyandoro ◽  
John E.D. Ekoru

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