Association ofCYP46gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis

2013 ◽  
Vol 123 (4) ◽  
pp. 226-232 ◽  
Author(s):  
Chunhui Jin ◽  
Feng Zhang ◽  
Jianzhong Zhu ◽  
Jianmin Yuan ◽  
Minghua Xia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Chinese Han ◽  
Sporadic Alzheimer’S Disease

scholarly journals Association Study of Clusterin Polymorphism rs11136000 With Late Onset Alzheimer’s Disease in Chinese Han Population

2011 ◽  
Vol 26 (8) ◽  
pp. 627-630 ◽  
Author(s):  
Jian-Fang Ma ◽  
Li-hua Liu ◽  
Yu Zhang ◽  
Ying Wang ◽  
Yu-Lei Deng ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Meta Analysis ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Published Data ◽  
Chinese Han ◽  
Han Population ◽  
Pcr Rflp

Objective: We conducted a case–control study to investigate whether clusterin polymorphism (rs11136000) was associated with late-onset Alzheimer’s disease in Chinese Han population. Methods: Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) assay was performed on genotype rs11136000 and APOEε4 in 127 patients with late-onset Alzheimer’s disease and 143 control individuals. Previous published data from other Chinese samples was also included for further meta-analysis. Results: APOEε4 was demonstrated to increase the risk of Alzheimer’s disease in Chinese population (odds ratio = 2.35, 95% confidence interval: 1.40-3.96). There is no significant association between clusterin rs11136000 with late-onset sporadic AD in our small cohort. However, meta-analysis revealed significant allele and genotype differences between Alzheimer’s disease and controls following a recessive model. Conclusion: Clusterin (rs11136000) was associated with Alzheimer’s disease in Chinese Han population.

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