Genetic polymorphism of interleukin 1β −511C/T and susceptibility to sporadic Alzheimer’s disease: a meta-analysis

2012 ◽  
Vol 40 (2) ◽  
pp. 1827-1834 ◽  
Author(s):  
Hai Yuan ◽  
Qing Xia ◽  
Pingping Ge ◽  
Shaowei Wu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Polymorphism ◽  
Meta Analysis ◽  
Interleukin 1Β ◽  
Sporadic Alzheimer’S Disease

scholarly journals Complement receptor 1 genetic polymorphism contributes to sporadic Alzheimer’s disease susceptibility in Caucasians: a meta-analysis

2020 ◽  
Vol 40 (6) ◽  
Author(s):  
Hai Yuan ◽  
Lingling Du ◽  
Pingping Ge
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Polymorphism ◽  
Statistical Difference ◽  
Meta Analysis ◽  
Recessive Model ◽  
Complement Receptor ◽  
Dominant Model ◽  
Sporadic Alzheimer’S Disease ◽  
Complement Receptor 1

Abstract Complement receptor 1 (CR1) plays an important role in the development of sporadic Alzheimer’s disease (SAD) in Caucasians. However, the influence of CR1 (rs6656401A/G and rs3818361T/C) genetic polymorphisms on the risk of SAD remains controversial. A meta-analysis of 18 case–control studies was performed to derive a more precise association of CR1 (rs6656401A/G or rs3818361T/C) genetic polymorphism with the risk of SAD in Caucasians. A statistical difference was found in the dominant model (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.16–1.30, P=0.00), recessive model (OR: 1.28, 95% CI: 1.05–1.56, P=0.02), homozygote comparison (OR: 1.36, 95% CI: 1.12–1.66, P=0.002) or heterozygote comparison (AG versus GG) (OR: 1.21, 95% CI: 1.15–1.29, P=0.00) of CR1 rs6656401A/G. For CR1 rs3818361T/C, a statistical difference was observed in the dominant model (OR: 1.21, 95% CI: 1.13–1.31, P=0.00), recessive model (OR: 1.28, 95% CI: 1.07–1.53, P=0.006), homozygote comparison (OR: 1.35, 95% CI: 1.13–1.62, P=0.001) or heterozygote comparison (TC versus CC) (OR: 1.20, 95% CI: 1.11–1.29, P=0.00). In summary, despite some limitations, the present meta-analysis indicated that rs6656401A/G or rs3818361T/C polymorphism was related to SAD risk. Moreover, a carrier of rs6656401A/G or T carrier of rs3818361T/C in CR1 genetic polymorphism might be an increased factor for SAD in Caucasians.

Association ofCYP46gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis

2013 ◽  
Vol 123 (4) ◽  
pp. 226-232 ◽  
Author(s):  
Chunhui Jin ◽  
Feng Zhang ◽  
Jianzhong Zhu ◽  
Jianmin Yuan ◽  
Minghua Xia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Chinese Han ◽  
Sporadic Alzheimer’S Disease

Association between the interleukin-1β polymorphisms and Alzheimer's disease: A systematic review and meta-analysis

2008 ◽  
Vol 59 (1) ◽  
pp. 155-163 ◽  
Author(s):  
Danilo Di Bona ◽  
Antonella Plaia ◽  
Sonya Vasto ◽  
Luca Cavallone ◽  
Francesco Lescai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Interleukin 1Β

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease

1999 ◽  
Vol 262 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Andreas Papassotiropoulos ◽  
Metin Bagli ◽  
Oliver Feder ◽  
Frank Jessen ◽  
Wolfgang Maier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Polymorphism ◽  
Cathepsin D ◽  
Sporadic Alzheimer’S Disease

An Updated Meta-Analysis of the Association between SORL1 Variants and the Risk for Sporadic Alzheimer's Disease

2013 ◽  
Vol 37 (2) ◽  
pp. 429-437 ◽  
Author(s):  
Chunhui Jin ◽  
Xiaowei Liu ◽  
Fuquan Zhang ◽  
Yue Wu ◽  
Jianmin Yuan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Meta Analysis ◽  
Sporadic Alzheimer’S Disease
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