Differential diagnosis of serous papillary carcinoma of the gynaecological tract and basal breast carcinoma: an immunohistochemical approach

Abstract Nodular hidradenoma is an uncommon cutaneous adnexal tumor arising from sweat glands. In the skin, it usually presents as a solitary dermal nodule; excision is curative in most cases. In rare instances, it may present as a breast mass and can mimic breast carcinoma clinically and radiologically, causing diagnostic dilemmas for the treating physician and pathologist. Herein, we discuss a case of nodular hidradenoma in a 20-year-old Hispanic woman as a rapidly growing mass in the breast that mimicked breast carcinoma. We discuss the rare presentation of this uncommon tumor and the differential diagnosis of this entity, as well as the results of our literature review on the topic.

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BRCA germline mutations in Jewish women with uterine serous papillary carcinoma

Gynecologic Oncology ◽

10.1016/j.ygyno.2003.11.009 ◽

2004 ◽

Vol 92 (2) ◽

pp. 521-524 ◽

Cited By ~ 83

Author(s):

Ofer Lavie ◽

Gila Hornreich ◽

Alon Ben-Arie ◽

Gad Rennert ◽

Yoram Cohen ◽

...

Keyword(s):

Papillary Carcinoma ◽

Germline Mutations ◽

Jewish Women ◽

Serous Papillary Carcinoma

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Overexpression of EpCAM in Uterine Serous Papillary Carcinoma: Implications for EpCAM-Specific Immunotherapy With Human Monoclonal Antibody Adecatumumab (MT201)

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-09-0675 ◽

2010 ◽

Vol 9 (1) ◽

pp. 57-66 ◽

Cited By ~ 25

Author(s):

Karim El-Sahwi ◽

Stefania Bellone ◽

Emiliano Cocco ◽

Francesca Casagrande ◽

Marta Bellone ◽

...

Keyword(s):

Monoclonal Antibody ◽

Papillary Carcinoma ◽

Specific Immunotherapy ◽

Human Monoclonal Antibody ◽

Serous Papillary Carcinoma

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Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast

SAGE Open Medicine ◽

10.1177/2050312118811542 ◽

2018 ◽

Vol 6 ◽

pp. 205031211881154 ◽

Cited By ~ 3

Author(s):

Ichiro Maeda ◽

Shinya Tajima ◽

Yoshihide Kanemaki ◽

Koichiro Tsugawa ◽

Masayuki Takagi

Keyword(s):

Differential Diagnosis ◽

Papillary Carcinoma ◽

Carcinoma In Situ ◽

Immunohistochemical Staining ◽

Immunohistochemical Analysis ◽

Intraductal Papilloma ◽

Solid Papillary Carcinoma ◽

Usual Ductal Hyperplasia ◽

Ductal Hyperplasia

Objectives: The aim of this study was to use immunohistochemistry to differentiate solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia (IPUDH). Three types of high-molecular-weight cytokeratins (CKs) – CK5/6, CK14, and CK34betaE12 – were targeted. Methods: We studied 17 patients with solid papillary carcinoma in situ and 18 patients with IPUDH diagnosed by at least two pathologists. Immunohistochemical analyses used antibodies to CK5/6, CK14, and CK34betaE12 to make the differential diagnosis of solid papillary carcinoma in situ versus IPUDH. Immunohistochemical staining was scored as 0–5 using Allred score. Results: Immunohistochemistry with CK5/6 and CK14 antibodies produced scores of 0–3 in all patients with solid papillary carcinoma in situ and 2–5 in all patients with IPUDH. Immunohistochemical staining with CK34betaE12 antibody produced scores of 1–3 in all patients with solid papillary carcinoma and 3–5 in all patients with IPUDH. In tissues from patients with IPUDH, significantly more cells were stained with CK34betaE12 than CK5/6 ( p < 0.05) or CK14 ( p < 0.05). Conclusion: The immunoreactivity of CK5/6, CK14, and CK34betaE12 antibodies was useful to differentiate solid papillary carcinoma in situ from IPUDH. CK34betaE12 is especially useful for distinguishing solid papillary carcinoma from IPUDH.

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