The influence of pH,pCO2and concentrations of dyshemoglobins on the oxygen dissociation curve (ODC) of human blood determined by non-linear least squares regression analysis

1990 ◽  
Vol 50 (sup203) ◽  
pp. 163-168
Author(s):  
P. R. Sørensen
2000 ◽  
Vol 77 (5) ◽  
pp. 669 ◽  
Author(s):  
Sidney Young ◽  
Andrzej Wierzbicki

1976 ◽  
Vol 65 (1) ◽  
pp. 21-38
Author(s):  
G. M. Hughes ◽  
J. G. O'Neill ◽  
W.J. van Aardt

1. A detailed account is given of an electrolytic method for determining the oxygen dissociation curve of fish blood using a single sample of 50–100 mul for the whole curve. The accuracy and some of the problems arising from its uses are discussed. 2. Oxygen dissociation curves have been determined for trout blood and human blood at temperatures of 15 and 37 degrees C. The relationship between P50 and temperature is similar to that obtained using other methods. Absolute values of P50 are generally lower than those obtained by other methods, especially in the case of fish blood. 3. The effect of PCO2 and pH on the oxygen dissociation curve of trout blood is tested and it is shown that PCO2 has a more marked effect than pH when the other factor is maintained at a constant level. The Bohr factor (delta log P50/delta pH) appears to be approximately the same and independent of the PCO2. 4.The P50 of ray blood determined from fish during and after an operation showed an increased Bohr factor.


2020 ◽  
Vol 30 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Elena Moltchanova ◽  
Shirin Sharifiamina ◽  
Derrick J. Moot ◽  
Ali Shayanfar ◽  
Mark Bloomberg

AbstractHydrothermal time (HTT) models describe the time course of seed germination for a population of seeds under specific temperature and water potential conditions. The parameters of the HTT model are usually estimated using either a linear regression, non-linear least squares estimation or a generalized linear regression model. There are problems with these approaches, including loss of information, and censoring and lack of independence in the germination data. Model estimation may require optimization, and this can have a heavy computational burden. Here, we compare non-linear regression with survival and Bayesian methods, to estimate HTT models for germination of two clover species. All three methods estimated similar HTT model parameters with similar root mean squared errors. However, the Bayesian approach allowed (1) efficient estimation of model parameters without the need for computation-intensive methods and (2) easy comparison of HTT parameters for the two clover species. HTT models that accounted for a species effect were superior to those that did not. Inspection of credibility intervals and estimated posterior distributions for the Bayesian HTT model shows that it is credible that most HTT model parameters were different for the two clover species, and these differences were consistent with known biological differences between species in their germination behaviour.


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