Follow-Up After Radical Surgery for Colorectal Cancer. Design of a Randomized Study

1988 ◽  
Vol 23 (sup149) ◽  
pp. 159-162 ◽  
Author(s):  
O. Kronborg ◽  
C. Fenger ◽  
E. Deichgräber ◽  
L. Hansen
Keyword(s):  
Colorectal Cancer ◽  
Radical Surgery ◽  
Randomized Study

A prospective randomized study of follow-up after radical surgery for colorectal cancer

1997 ◽  
Vol 84 (5) ◽  
pp. 666-669 ◽  
Author(s):  
B. J. Kjeldsen ◽  
O. Kronborg ◽  
C. Fenger ◽  
O. D. Jørgensen
Keyword(s):  
Colorectal Cancer ◽  
Radical Surgery ◽  
Randomized Study ◽  
Prospective Randomized Study

A prospective randomized study of follow-up after radical surgery for colorectal cancer

1997 ◽  
Vol 84 (5) ◽  
pp. 666-669 ◽  
Author(s):  
B. J. Kjeldsen ◽  
O. Kronborg ◽  
C. Fenger ◽  
O. D. Jørgensen
Keyword(s):  
Colorectal Cancer ◽  
Radical Surgery ◽  
Randomized Study ◽  
Prospective Randomized Study

Continuous versus intermittent chemotherapy in metastatic colorectal cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 3582-3582 ◽  
Author(s):  
C. G. Alexopoulos ◽  
A. A. Kotsori
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Stable Disease ◽  
Randomized Study ◽  
Intermittent Chemotherapy ◽  
Group A ◽  
Group B ◽  
Line Chemotherapy

3582 Background: The current policy concerning the duration of chemotherapy in metastatic colorectal cancer (MCC) varies considerably (Clin Oncol 1997;9:248) while no benefit of continuous versus intermittent 5-FU was found in a published randomized study (Lancet 2003;361:457). Serious cumulative toxicity is not usually a problem with long-term 5-FU/FA, but this is not the case with contemporary triple regimens (FOLFIRI, FOLFOX). We, therefore, performed a randomized study of continuous versus intermittent FOLFIRI as first line chemotherapy in MCC. Methods: Patients with MCC and ECOG 0–2 were given 6 biweekly courses of FOLFIRI (Irinotecan 180mg/m2 + De Gramont). Patients with response or stable disease were randomized to continue with another 6 FOLFIRI (group A) or discontinue until relapse when 6 FOLFIRI were readministered (group B). Time to progression (TTP) was calculated from study entrance until 1st progression for group A, and 2nd progression for group B, and overall survival (OS) from study entrance until death. Results: Fifty eight (M=38, F=20) patients entered into the study. Two (3.4%) withdrew before evaluation, 1 (1.7%) died of stroke, 1 (1.7%) was lost to FU and 15 (26%) progressed before or at the completion of 6 FOLFIRI. Thirty nine (67%) patients (M=25, F=14), median age 69 (38–79) responded (21=54%) or had stable disease (18=46%) and were randomized: 19 (49%) to group A and 20 (51%) to group B. Median TTP was 8 months 95% CI: 5.3–10.7) for group A and 9 (95% CI: 7.8–10) for group B (p=NS). 10/19 (52%) in group A received 2nd line chemotherapy vs 7/20 (35%) in group B (p=NS). With a median follow-up of 13 months, 21 patients are alive (12 in group A and 9 in group B). Median OS was 21 months (95% CI: 15 - 26.7) in group A vs 15 (95% CI: 12.6 - 17.3) in group B (p=NS), and 18 months (95% CI: 15.5 - 21) for all 39 patients. Conclusions: In MCC, when response or stability has been achieved after 6 courses ofFOLFIRI there seemstobe little more benefit from continuing chemotherapy than from retreating patients at relapse No significant financial relationships to disclose.

scholarly journals Management of patients with early-stage colon cancer: guidelines of the Italian Medical Oncology Association

ESMO Open ◽  
2020 ◽  
Vol 5 (6) ◽  
pp. e001001
Author(s):  
Lisa Salvatore ◽  
Marco Imperatori ◽  
Ermenegildo Arnoldi ◽  
Carlo Carnaghi ◽  
Stefano Cordio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Early Diagnosis ◽  
Medical Oncology ◽  
Radical Surgery ◽  
Early Stage ◽  
Colorectal Cancers ◽  
Early Stage Colon Cancer ◽  
Cancer Guidelines

About 75% of colorectal cancers are diagnosed as early stage, in which radical surgery is achievable. In the last decade, in Italy, the overall incidence of colorectal cancer has remained stable, while mortality gradually decreased, which is attributable to early diagnosis and improved medical, surgical and locoregional treatments. The Italian Medical Oncology Association formulated guidelines to manage early-stage colon cancer, including screening, diagnosis, treatment and follow-up, which we herein present.

The Follow-up After Radical Surgery of Colorectal Cancer: Is it Time for a “Tailored” Strategy?

2011 ◽  
Vol 10 (2) ◽  
pp. 81-84
Author(s):  
Margherita Nannini ◽  
Maria Abbondanza Pantaleo ◽  
Guido Biasco
Keyword(s):  
Colorectal Cancer ◽  
Radical Surgery

scholarly journals Clinicopathological Features of Stage I–III Colorectal Cancer Recurrence Over 5 Years After Radical Surgery Without Receiving Neoadjuvant Therapy: Evidence From a Large Sample Study

2021 ◽  
Vol 8 ◽  
Author(s):  
Dakui Luo ◽  
Yufei Yang ◽  
Zezhi Shan ◽  
Qi Liu ◽  
Sanjun Cai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Neoadjuvant Therapy ◽  
Radical Surgery ◽  
Early Stage ◽  
Multivariate Logistic Regression Analysis ◽  
Late Recurrence ◽  
Signet Ring Cell ◽  
Stage I ◽  
Cancer Center

Late recurrence (5 or more years) after radical resection of colorectal cancer (CRC) is rare. This study aims to investigate the features of late recurrence in stage I–III CRC. A total of 9,754 stage I–III patients with CRC who underwent radical surgery without receiving neoadjuvant therapy, at the Fudan University Shanghai Cancer Center (FUSCC), were enrolled in this study. These patients were divided into three groups: early recurrence (3 months−2 years), intermediate recurrence (2–5 years), and late recurrence (over 5 years). The median duration of follow-up was 53.5 ± 30.1 months. A total of 2,341 (24.0%) patients developed recurrence. The late recurrence rate was 11.7%. Patients with a higher risk of late recurrence were more likely to be older, to be at the T4 stage, to have a higher degree of colon cancer, to have a lower frequency of signet ring cell carcinoma, to have fewer poorly differentiated tumors, to be at the early stage of CRC, along with less perineural and vascular invasions. Multivariate logistic regression analysis identified age, differentiation, T stage, N stage, perineural, and vascular invasions as independent factors for late recurrence. Late recurrent CRC has some distinctive characteristics. Although recurrence over 5 years after surgery is infrequent, an enhanced follow-up is still needed for the selected patients after 5 years.

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