Gastric Accommodation in Functional Dyspepsia

1997 ◽  
Vol 32 (3) ◽  
pp. 193-197 ◽  
Author(s):  
Arnold Berstad ◽  
Trygve Hauksen ◽  
Odd Helge Gilja ◽  
Kristian Hveem ◽  
Karl Anton Undeland ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Accommodation

Persian herbal medicine in functional dyspepsia: a systematic review article.

2020 ◽  
Vol 17 ◽  
Author(s):  
Maryam Azimi ◽  
Mohammad Javad Zahedi
Keyword(s):  
Clinical Trials ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Nigella Sativa ◽  
Curcuma Longa ◽  
Crocus Sativus ◽  
Herbal Remedies ◽  
Asparagus Racemosus ◽  
Gastric Accommodation ◽  
Cynara Scolymus

Introduction: According to Rome IV, functional dyspepsia is diagnosed with presence of dyspepsia in the absence of organic or metabolic causes. FD caused by several factors such as impaired gastric accommodation and hypersensitivity to gastric distention. Several studies have reported effectiveness of herbal medicine on FD. This article, thus, reviews Persian herbal medicine in FD. Method: Electronic databases including Pubmed, Scopus, Cochrain, Embase, Web of science and Ovid were searched so as to find clinical articles related to dyspepsia and herbal medicine by July 2019. Our search strategies were traditional medicine, complementary and alternative medicine, herb, plant, and dyspepsia. We excluded all articles except Persian clinical trials. Results: We found 34 clinical trials with 15 herbs and 4 compound herbal remedies like Asparagus racemosus, Brassica oleracea, Cynara scolymus, Ocimum basilicum, Mentha longifolia, Mentha pulegium, Mentha piperata, Pimpinella anisum, Nigella sativa, Mastic gum, Curcuma longa, Pistatio atlantica, Glycyrrhiza glabra, Solanum tuberosum and Zingiber officinale and compound remedies of Rosa damascene & Crocus sativus, Trachyspermum copticom & Apium graveolence, Carum carvi & Mentha pipperata, Gingiber officinalis & Cynara scolymus are effective in functional dyspepsia. Conclusion: Many people use herbal and traditional remedies for treatment of disorders such as gastrointestinal disordersو , especially in Asian countries. Several studies reported the efficacy of herbal medicine in functional dyspepsia. Although their mechanisms are not fully understood, it seems they can modulate GI motility and improve symptoms of FD.

scholarly journals Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial

2020 ◽  
Vol 318 (4) ◽  
pp. G635-G645 ◽  
Author(s):  
Justin Brandler ◽  
Laurence J. Miller ◽  
Xiao Jing Wang ◽  
Duane Burton ◽  
Irene Busciglio ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Animal Studies ◽  
Delayed Gastric Emptying ◽  
Gastrointestinal Hormones ◽  
Receptor Activation ◽  
Gastric Accommodation ◽  
Double Blind ◽  
Secretin Receptor ◽  
Therapeutic Mechanism

Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD). Secretin is a key regulator of GA in animal studies. Our aim was to study the effects of secretin on gastric motility, satiation, postprandial symptoms, and key hormones. We performed two double-blind, randomized, saline-controlled crossover trials in 10 healthy volunteers and 10 patients with FD by Rome IV criteria. We used measured GA (by validated SPECT method) after a 111In radiolabeled Ensure 300-mL meal and quantified gastric emptying for 30 min by scintigraphy. Satiation was measured by volume to fullness (VTF) and maximum tolerated volume (MTV) on an Ensure nutrient drink test and postprandial symptoms 30 min post-MTV. Fasting and postprandial GLP-1, GIP, and HPP were measured. The ages and sex distribution of healthy controls and patients with FD were similar. Compared with placebo, secretin delayed gastric emptying at 30 min in both health [−11% (−16, −4), P = 0.004]; and FD [−8% (−9, 0), P = 0.03]. Satiation (VTF and MTV), GA, and plasma levels of GLP-1, GIP, and HPP did not differ between treatment arms in health or FD. On ANCOVA analysis (adjusting for age and sex), secretin did not consistently increase postprandial symptoms in health or FD. Secretin delayed gastric emptying in both health and FD without significantly altering GA, VTF, or MTV or selected hormones. Thus, secretin receptor activation may provide a novel therapeutic mechanism for patients with FD and rapid gastric emptying. NEW & NOTEWORTHY The naturally occurring hormone secretin retards gastric emptying of solids without deleteriously affecting gastric accommodation, satiation, other upper gastrointestinal hormones, or postprandial symptoms. Given these findings, a subset of patients with rapid gastric emptying (e.g., the estimated 20% of patients with functional dyspepsia) could be candidates for treatments that stimulate a secretin receptor such as sacubitril, which inhibits neprilysin, an enzyme that degrades secretin.

scholarly journals An Alternative to Current Therapies of Functional Dyspepsia: Self-Administrated Transcutaneous Electroacupuncture Improves Dyspeptic Symptoms

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Ting Ji ◽  
Xueliang Li ◽  
Lin Lin ◽  
Liuqin Jiang ◽  
Meifeng Wang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Gastric Emptying ◽  
Functional Dyspepsia ◽  
Therapeutic Potential ◽  
Treatment Options ◽  
Treatment Method ◽  
Gastric Accommodation ◽  
Dyspeptic Symptoms ◽  
New Treatment

Functional dyspepsia is of high prevalence with little treatment options. The aim of this study was to develop a new treatment method using self-management transcutaneous electroacupuncture (TEA) for functional dyspepsia (FD). Twenty-eight patients with FD were enrolled and underwent a crossover clinical trial with 2-week TEA at ST36 and PC6 and 2-week sham-TEA at nonacupuncture sham-points. Questionnaires were used to assess symptoms of dyspepsia and quality of life. Physiological testing included gastric emptying and electrogastrography. It was found that (1) TEA but not sham-TEA significantly improved dyspeptic symptoms and 4 domains in quality of life; improvement was also noted in self-rated anxiety and depression scores; (2) gastric emptying was significantly and substantially increased with 2-week TEA but not sham-TEA; and (3) gastric accommodation was also improved with TEA but not sham-TEA, reflected as increased ingested nutrient volumes at the levels of satiety and maximum tolerance. These findings suggest a therapeutic potential of self-administrated TEA method for functional dyspepsia, possibly attributed to improvement in gastric motility.

Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity

2021 ◽  
Author(s):  
Ying Zhu ◽  
Feng xu ◽  
Dewen Lu ◽  
Peijing Rong ◽  
Jiafei Cheng ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Slow Waves ◽  
Dyspeptic Symptom ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Efferent Activity ◽  
Gastric Slow Waves

Objectives: This study was designed to investigate whether transcutaneous auricular vagal nerve stimulation (taVNS) would be able to improve major pathophysiologies of functional dyspepsia (FD) in patients with FD. Methods: Acute: Thirty-six FD patients (21F) were studied in two sessions (taVNS and sham-ES). Physiological measurements, including gastric slow waves, gastric accommodation and autonomic functions, were assessed by the electrogastrogram (EGG), a nutrient drink test and the spectral analysis of heart rate variability derived from the electrocardiogram (ECG), respectively. Chronic: Thirty-six FD patients (25F) were randomized to receive 2-week taVNS or sham-ES. The dyspeptic symptom scales, anxiety and depression scores and the same physiological measurements were assessed at the beginning and the end of the 2-week treatment. Results: Acute: In comparison with sham-ES, acute taVNS improved gastric accommodation (p=0.008), increased the percentage of normal gastric slow waves (%NSW, fasting: p=0.010; fed: p=0.007) and vagal activity (fasting: p=0.056; fed: p=0.026). Chronic：In comparison with baseline, 2-week taVNS but not sham-ES reduced symptoms of dyspepsia (p=0.010), decreased the scores of anxiety (p=0.002) and depression (p<0.001), improved gastric accommodation (p<0.001) and the %NSW (fasting: p<0.05; fed: p<0.05) by enhancing vagal efferent activity (fasting: p=0.015; fed: p=0.048). Compared with the HC, the patients showed increased anxiety (p<0.001) and depression (p<0.001), and decreased gastric accommodation (p<0.001) and %NSW (p<0.001) as well as decreased vagal activity (fasting: p=0.047). Conclusions: The noninvasive taVNS has a therapeutic potential for treating non-severe FD by improving gastric accommodation and gastric pace-making activity via enhancing vagal activity.

Role of impaired gastric accommodation to a meal in functional dyspepsia

1998 ◽  
Vol 115 (6) ◽  
pp. 1346-1352 ◽  
Author(s):  
Jan Tack ◽  
Hubert Piessevaux ◽  
Bernard Coulie ◽  
Philip Caenepeel ◽  
Jozef Janssens
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Accommodation
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