Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity

2021 ◽  
Author(s):  
Ying Zhu ◽  
Feng xu ◽  
Dewen Lu ◽  
Peijing Rong ◽  
Jiafei Cheng ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Slow Waves ◽  
Dyspeptic Symptom ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Efferent Activity ◽  
Gastric Slow Waves

Objectives: This study was designed to investigate whether transcutaneous auricular vagal nerve stimulation (taVNS) would be able to improve major pathophysiologies of functional dyspepsia (FD) in patients with FD. Methods: Acute: Thirty-six FD patients (21F) were studied in two sessions (taVNS and sham-ES). Physiological measurements, including gastric slow waves, gastric accommodation and autonomic functions, were assessed by the electrogastrogram (EGG), a nutrient drink test and the spectral analysis of heart rate variability derived from the electrocardiogram (ECG), respectively. Chronic: Thirty-six FD patients (25F) were randomized to receive 2-week taVNS or sham-ES. The dyspeptic symptom scales, anxiety and depression scores and the same physiological measurements were assessed at the beginning and the end of the 2-week treatment. Results: Acute: In comparison with sham-ES, acute taVNS improved gastric accommodation (p=0.008), increased the percentage of normal gastric slow waves (%NSW, fasting: p=0.010; fed: p=0.007) and vagal activity (fasting: p=0.056; fed: p=0.026). Chronic：In comparison with baseline, 2-week taVNS but not sham-ES reduced symptoms of dyspepsia (p=0.010), decreased the scores of anxiety (p=0.002) and depression (p<0.001), improved gastric accommodation (p<0.001) and the %NSW (fasting: p<0.05; fed: p<0.05) by enhancing vagal efferent activity (fasting: p=0.015; fed: p=0.048). Compared with the HC, the patients showed increased anxiety (p<0.001) and depression (p<0.001), and decreased gastric accommodation (p<0.001) and %NSW (p<0.001) as well as decreased vagal activity (fasting: p=0.047). Conclusions: The noninvasive taVNS has a therapeutic potential for treating non-severe FD by improving gastric accommodation and gastric pace-making activity via enhancing vagal activity.

115 – Transcutaneous Auricular Vagal Nerve Stimulation Improves Functional Dyspepsia by Enhancing Vagal Efferent Activity

2019 ◽  
Vol 156 (6) ◽  
pp. S-30
Author(s):  
Ying Zhu ◽  
Feng Xu ◽  
Dewen Lu ◽  
Lin Lin ◽  
Jiande Chen
Keyword(s):  
Functional Dyspepsia ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Efferent Activity

733 AMELIORATING EFFECTS AND MECHANISMS OF AURICULAR VAGAL NERVE STIMULATION IN A RODENT MODEL OF FUNCTIONAL DYSPEPSIA

2021 ◽  
Vol 160 (6) ◽  
pp. S-148
Author(s):  
Liwei Hou ◽  
Juan Han ◽  
Wei Wei ◽  
Jiande Chen ◽  
Jiliang Fang ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Nerve Stimulation ◽  
Rodent Model ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation

scholarly journals Sacral nerve stimulation increases gastric accommodation in rats: a spinal afferent and vagal efferent pathway

2020 ◽  
Vol 318 (3) ◽  
pp. G574-G581
Author(s):  
Feng Ye ◽  
Yi Liu ◽  
Shiying Li ◽  
Sujuan Zhang ◽  
Robert D. Foreman ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Gastric Fundus ◽  
Vagal Activity ◽  
Sprague Dawley ◽  
Gastric Accommodation ◽  
Gastric Tone ◽  
Efferent Activity ◽  
Sacral Nerve ◽  
Efferent Pathway

Impaired gastric accommodation (GA) has been frequently reported in various gastrointestinal diseases. No standard treatment strategy is available for treating impaired GA. We explored the possible effect of sacral nerve stimulation (SNS) on GA and discovered a spinal afferent and vagal efferent mechanism in rats. Sprague-Dawley rats (450–500 g) with a chronically implanted gastric cannula and ECG electrodes were studied in a series of sessions to study: 1) the effects of SNS with different parameters on gastric tone, compliance, and accommodation using a barostat device; two sets of parameters were tested as follows: parameter 1) 5 Hz, 500 µs, 10 s on 90 s off; 90% motor threshold and parameter 2) same as parameter 1 but 25 Hz; 2) the involvement of spinal afferent pathway via detecting c-fos immunoreactive (IR) cells in the nucleus of the solitary tract (NTS) of the brain; 3) the involvement of vagal efferent activity via the spectral analysis of heart rate variability derived from the ECG; and 4) the nitrergic mechanism, Nω-nitro-l-arginine methyl ester (l-NAME), a nitric oxide synthase (NOS) inhibitor, was given before SNS at 5 Hz. Compared with sham-SNS: 1) SNS at 5 Hz inhibited gastric tone and increased gastric compliance and GA. No difference was noted between the stimulation frequencies of 5 and 25 Hz. 2) SNS increased the expression of c-fos in the NTS. 3) SNS increased cardiac vagal efferent activity and decreased the sympathovagal ratio. 4) l-NAME blocked the relaxation effect of SNS. In conclusion, SNS with certain parameters relaxes gastric fundus and improves gastric accommodation mediated via a spinal afferent and vagal efferent pathway. NEW & NOTEWORTHY Currently, there is no adequate medical therapy for impaired gastric accommodation, since medications that relax the fundus often impair antral peristalsis and thus further delay gastric emptying that is commonly seen in patients with functional dyspepsia or gastroparesis. The advantage of the potential sacral nerve stimulation therapy is that it improves gastric accommodation by enhancing vagal activity, and the enhanced vagal activity would lead to enhanced antral peristalsis rather than inhibiting it.

scholarly journals Ameliorating Effect of Transcutaneous Electroacupuncture on Impaired Gastric Accommodation in Patients with Postprandial Distress Syndrome-Predominant Functional Dyspepsia: A Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Feng Xu ◽  
Yan Tan ◽  
Zhihui Huang ◽  
Nina Zhang ◽  
Yuemei Xu ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Motility ◽  
Distress Syndrome ◽  
Therapeutic Potential ◽  
Vagal Activity ◽  
Gastric Accommodation ◽  
Fed State ◽  
Gastric Slow Waves ◽  
Drink Test ◽  
Tolerable Volume

Patients with functional dyspepsia (FD) have both reduced gastric accommodation and impaired gastric motility that are difficult to treat. The aim of this study was to investigate the therapeutic potential of transcutaneous electroacupuncture (TEA) for both of these disorders in FD patients. Acute experiments were performed in FD patients to study the effect of TEA and sham-TEA on gastric accommodation assessed by a nutrient drink test and gastric motility assessed by the measurement of the electrogastrogram (EGG). TEA or sham-TEA was performed via cutaneous electrodes at acupoints ST36 and PC6 or sham-points nonacupoints. It was found that (1) gastric accommodation (maximum tolerable volume) was reduced in FD patients compared with the controlsP<0.03. TEA improved gastric accommodation in FD patientsP<0.02. (2) Acute TEA significantly increased the percentage and power of normal gastric slow waves in the fed state assessed in the FD patients by the EGG in comparison with sham-TEA. (3) TEA increased vagal activity assessed by the spectral analysis of the heart rate variability in the fed state in FD patients. It was concluded that needleless method of transcutaneous electroacupuncture may have a therapeutic potential for treating both impaired gastric accommodation and impaired gastric motility in patients with FD.

scholarly journals Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis

2017 ◽  
Vol 313 (3) ◽  
pp. G192-G202 ◽  
Author(s):  
Haifeng Jin ◽  
Jie Guo ◽  
Jiemin Liu ◽  
Bin Lyu ◽  
Robert D. Foreman ◽  
...  
Keyword(s):  
Nerve Stimulation ◽  
Plasma Levels ◽  
Inflammatory Responses ◽  
Rodent Model ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Vagal Activity ◽  
Trinitrobenzenesulfonic Acid ◽  
Histological Score ◽  
Anti Inflammatory

The purpose of this study was to determine the effects and mechanisms of vagal nerve stimulation (VNS) and additive effects of electroacupuncture (EA) on colonic inflammation in a rodent model of IBD. Chronic inflammation in rats was induced by intrarectal TNBS (2,4,6-trinitrobenzenesulfonic acid). The rats were then treated with sham ES (electrical stimulation), VNS, or VNS + EA for 3 wk. Inflammatory responses were assessed by disease activity index (DAI), macroscopic scores and histological scores of colonic tissues, plasma levels of TNFα, IL-1β, and IL-6, and myeloperoxidase (MPO) activity of colonic tissues. The autonomic function was assessed by the spectral analysis of heart rate variability (HRV) derived from the electrocardiogram. It was found that 1) the area under curve (AUC) of DAI was substantially decreased with VNS + EA and VNS, with VNS + EA being more effective than VNS ( P < 0.001); 2) the macroscopic score was 6.43 ± 0.61 in the sham ES group and reduced to 1.86 ± 0.26 with VNS ( P < 0.001) and 1.29 ± 0.18 with VNS + EA ( P < 0.001); 3) the histological score was 4.05 ± 0.58 in the sham ES group and reduced to 1.93 ± 0.37 with VNS ( P < 0.001) and 1.36 ± 0.20 with VNS + EA ( P < 0.001); 4) the plasma levels of TNFα, IL-1β, IL-6, and MPO were all significantly decreased with VNS and VNS + EA compared with the sham ES group; and 5) autonomically, both VNS + EA and VNS substantially increased vagal activity and decreased sympathetic activity compared with sham EA ( P < 0.001, P < 0.001, respectively). In conclusion, chronic VNS improves inflammation in TNBS-treated rats by inhibiting proinflammatory cytokines via the autonomic mechanism. Addition of noninvasive EA to VNS may enhance the anti-inflammatory effect of VNS. NEW & NOTEWORTHY This is the first study to address and compare the effects of vagal nerve stimulation (VNS), electrical acupuncture (EA) and VNS + EA on TNBS (2,4,6-trinitrobenzenesulfonic acid)-induced colitis in rats. The proposed chronic VNS + EA, VNS, and EA were shown to decrease DAI and ameliorate macroscopic and microscopic damages in rats with TNBS-induced colitis via the autonomic pathway. The addition of EA to VNS provided a significant effect on the behavioral assessment of inflammation (DAI, CMDI, and histological score) but not on cytokines or mechanistic measurements, suggesting an overall systemic effect of EA. View this article’s corresponding video summary at https://youtu.be/-rEz6HMkErM .

Benefit of vagal nerve stimulation in epilepsia partialis continua: a case report

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
C Bussmann ◽  
HM Meinck ◽  
HH Steiner ◽  
W Broxtermann ◽  
CG Bien ◽  
...  
Keyword(s):  
Case Report ◽  
Nerve Stimulation ◽  
Vagal Nerve ◽  
Vagal Nerve Stimulation ◽  
Epilepsia Partialis Continua
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