Applications of high-voltage paper electrophoresis for the characterization of drug metabolites

Xenobiotica ◽  
1981 ◽  
Vol 11 (12) ◽  
pp. 841-847 ◽  
Author(s):  
J. A. Bell ◽  
A. Bradbury ◽  
L. E. Martin ◽  
R. J. N. Tanner
Keyword(s):  
High Voltage ◽  
Paper Electrophoresis ◽  
Drug Metabolites

High-Voltage Paper Electrophoresis for Characterization of Drug Metabolites

1973 ◽  
Vol 62 (11) ◽  
pp. 1810-1817 ◽  
Author(s):  
Walter D. Conway ◽  
Vijay K. Batra ◽  
Alan Abramowitz
Keyword(s):  
High Voltage ◽  
Paper Electrophoresis ◽  
Drug Metabolites

Synthesis and chromatographic characterization of [Tc-99m]technetium-humic acid species

2000 ◽  
Vol 88 (2) ◽  
Author(s):  
D. Rößler ◽  
K. Franke ◽  
R. Süß ◽  
E. Becker ◽  
H. Kupsch
Keyword(s):  
Humic Acid ◽  
Stannous Chloride ◽  
Gel Permeation Chromatography ◽  
Paper Electrophoresis ◽  
Gel Permeation ◽  
Soil Humic Acid ◽  
Chromatographic Characterization ◽  
Ph Dependent ◽  
Layer Chromatography

A natural moor soil humic acid (HA) was labeled with Tc-99m via reduction of pertechnetate with stannous chloride. The humic acid species obtained were characterized by thin layer chromatography (TLC), gel permeation chromatography (GPC), sequential chromatographic analysis (SCA), paper electrophoresis and micropore filtration. Labeling was found to take place in all ranges of molecular weight. Due to the complex humic acid composition and the formation of hydroxo species the labeling yields strongly depend on the separation conditions, ranging from 42% to 80%. The pH-dependent distribution of mobile and immobile species was determined by SCA for HTcO

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