The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy

2013 ◽  
Vol 38 (6) ◽  
pp. 691-698 ◽  
Author(s):  
Yukihiro Shiga ◽  
Masahiko Shimura ◽  
Toshifumi Asano ◽  
Satoru Tsuda ◽  
Yu Yokoyama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Normal Subjects ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Posture Change

scholarly journals Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaku Itoh ◽  
Masato Furuhashi ◽  
Yosuke Ida ◽  
Hiroshi Ohguro ◽  
Megumi Watanabe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Fatty Acid ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Fatty Acid Binding ◽  
High Positive Correlation ◽  
Blood Biochemical

AbstractThe fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. The levels of V-FABP4 and V-VEGFA were significantly higher in PDR patients than in non-PDR patients (P < 0.001) with a high positive correlation (r = 0.72, P < 0.001) between them. The findings were not affected by body mass index values and the presence of vitreous hemorrhaging. Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST. Multiple regression analyses indicated that V-VEGFA, or V-FABP4, AST and HbA1c were independent predictors of V-FABP4 or V-VEGFA, respectively. Both were negatively correlated, but more evident in V-FABP4, with the ONH ocular blood flow.

scholarly journals Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates

2016 ◽  
Vol 254 (8) ◽  
pp. 1631-1636 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Postmenstrual Age ◽  
Normal Neonates

scholarly journals Reproducibility of Neonate Ocular Circulation Measurements Using Laser Speckle Flowgraphy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraclass Correlation ◽  
Ocular Blood Flow ◽  
Eye Diseases ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ocular Circulation ◽  
Time Index ◽  
Mean Blur Rate ◽  
Normal Sleep

Measuring the ocular blood flow in neonates may clarify the relationships between eye diseases and ocular circulation abnormalities. However, no method for noninvasively measuring ocular circulation in neonates is established. We used laser speckle flowgraphy (LSFG) modified for neonates to measure their ocular circulation and investigated whether this method is reproducible. During their normal sleep, we studied 16 subjects (adjusted age of 34–48 weeks) whose blood flow could be measured three consecutive times. While the subjects slept in the supine position, three mean blur rate (MBR) values of the optic nerve head (ONH) were obtained: the MBR-A (mean of all values), MBR-V (vessel mean), and MBR-T (tissue mean), and nine blood flow pulse waveform parameters in the ONH were examined. We analyzed the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) for each parameter. The COVs of the MBR values were all ≤10%. The ICCs of the MBR values were all >0.8. Good COVs were observed for the blowout score, blowout time, rising rate, falling rate, and acceleration time index. Although the measurement of ocular circulation in the neonates was difficult, our results exhibited reproducibility, suggesting that this method could be used in clinical research.

scholarly journals Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168190 ◽  
Author(s):  
Nikolaus Luft ◽  
Piotr A. Wozniak ◽  
Gerold C. Aschinger ◽  
Klemens Fondi ◽  
Ahmed M. Bata ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Flow Measurements ◽  
Blood Flow Measurements

scholarly journals Pulse Waveform Analysis of the Ocular Blood Flow Using Laser Speckle Flowgraphy before and after Glaucoma Treatment

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Satoko Masai ◽  
Kyoko Ishida ◽  
Ayako Anraku ◽  
Tetsuro Takumi ◽  
Goji Tomita
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Rate Of Change ◽  
Laser Speckle ◽  
Waveform Analysis ◽  
Laser Speckle Flowgraphy ◽  
Mean Deviation ◽  
Before And After ◽  
Glaucoma Treatment ◽  
Significant Change

Although reduction in intraocular pressure (IOP) is the principle of glaucoma treatment, impaired ocular blood flow is believed to play a role in the progression of glaucoma. This study evaluated the effect of glaucoma treatment on pulse waveforms for optic nerve head (ONH) microcirculation in patients with glaucoma. Fifty-one subjects were included on the basis of the glaucoma treatment administered, which involved instillation of prostaglandin (PG) analogs (PG group; n = 28) or trabeculectomy (trabeculectomy group; n = 23). ONH blood flow, represented by the mean blur rate (MBRT) and pulse waveforms, was measured using laser speckle flowgraphy before and 1 and 3 months after treatment. Three months after treatment, IOP exhibited a significant decrease (p<0.05). Although there was no significant change in MBRT after treatment, the acceleration time index (ATI) significantly decreased (p=0.034) in the PG group. In the trabeculectomy group, there was no significant change in the MBRT after treatment, while fluctuation (p=0.019) and blowout score (BOS) (p=0.036) exhibited significant decrease and increase, respectively. Multiple regression analysis showed that mean deviation was significantly associated with the rate of change in the BOS (p=0.013), age was a significant contributing factor for the rate of change in fluctuation in the trabeculectomy group, reflection was significantly associated with the ATI (p=0.037) in the in the PG group. Both glaucoma treatments can change the pulse waveforms, with MBRT remaining unchanged, and IOP reduction owing to the treatment may contribute to stable blood flow in the tissue area of the ONH. As impaired ocular blood flow plays a role in the progression of glaucomatous damage, it would be beneficial if glaucoma treatment could improve the stability of ONH microcirculation.

scholarly journals The Traditional Kampo Medicine Tokishakuyakusan Increases Ocular Blood Flow in Healthy Subjects

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Shin Takayama ◽  
Yukihiro Shiga ◽  
Taiki Kokubun ◽  
Hideyuki Konno ◽  
Noriko Himori ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Healthy Subjects ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Plain Water ◽  
Mean Blur Rate ◽  
The Mean

The aim of this study was to examine the effects of oral administration of kampo medical formulas on ocular blood flow (OBF). A crossover protocol was used to randomly administer five grams of yokukansan, tokishakuyakusan (TSS), keishibukuryogan, or hachimijiogan to 13 healthy blinded subjects (mean age: 37.3 ± 12.3 years). The mean blur rate, a quantitative OBF index obtained with laser speckle flowgraphy, was measured at the optic nerve head before and 30 minutes after administration. Blood pressure (BP) and intraocular pressure (IOP) were also recorded. No significant changes were observed in mean BP or IOP after the administration of any of the kampo medical formulas. There was a significant increase in OBF 30 minutes after administration of TSS (100% to 103.6 ± 6.9%,P<0.01). Next, TSS was administered to 19 healthy subjects (mean age: 32.0 ± 11.0 years) and OBF was measured before and 15, 30, 45, and 60 minutes after administration. Plain water was used as a control. OBF increased significantly after TSS administration compared to control (P<0.01) and also increased from 30 to 60 minutes after administration compared to baseline (P<0.05). These results suggest that TSS can increase OBF without affecting BP or IOP in healthy subjects.

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