scholarly journals Pulse Waveform Analysis of the Ocular Blood Flow Using Laser Speckle Flowgraphy before and after Glaucoma Treatment

2019 ◽  
Vol 2019 ◽  
pp. 1-14
Author(s):  
Satoko Masai ◽  
Kyoko Ishida ◽  
Ayako Anraku ◽  
Tetsuro Takumi ◽  
Goji Tomita
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Rate Of Change ◽  
Laser Speckle ◽  
Waveform Analysis ◽  
Laser Speckle Flowgraphy ◽  
Mean Deviation ◽  
Before And After ◽  
Glaucoma Treatment ◽  
Significant Change

Although reduction in intraocular pressure (IOP) is the principle of glaucoma treatment, impaired ocular blood flow is believed to play a role in the progression of glaucoma. This study evaluated the effect of glaucoma treatment on pulse waveforms for optic nerve head (ONH) microcirculation in patients with glaucoma. Fifty-one subjects were included on the basis of the glaucoma treatment administered, which involved instillation of prostaglandin (PG) analogs (PG group; n = 28) or trabeculectomy (trabeculectomy group; n = 23). ONH blood flow, represented by the mean blur rate (MBRT) and pulse waveforms, was measured using laser speckle flowgraphy before and 1 and 3 months after treatment. Three months after treatment, IOP exhibited a significant decrease (p<0.05). Although there was no significant change in MBRT after treatment, the acceleration time index (ATI) significantly decreased (p=0.034) in the PG group. In the trabeculectomy group, there was no significant change in the MBRT after treatment, while fluctuation (p=0.019) and blowout score (BOS) (p=0.036) exhibited significant decrease and increase, respectively. Multiple regression analysis showed that mean deviation was significantly associated with the rate of change in the BOS (p=0.013), age was a significant contributing factor for the rate of change in fluctuation in the trabeculectomy group, reflection was significantly associated with the ATI (p=0.037) in the in the PG group. Both glaucoma treatments can change the pulse waveforms, with MBRT remaining unchanged, and IOP reduction owing to the treatment may contribute to stable blood flow in the tissue area of the ONH. As impaired ocular blood flow plays a role in the progression of glaucomatous damage, it would be beneficial if glaucoma treatment could improve the stability of ONH microcirculation.

scholarly journals Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kaku Itoh ◽  
Masato Furuhashi ◽  
Yosuke Ida ◽  
Hiroshi Ohguro ◽  
Megumi Watanabe ◽  
...  
Keyword(s):  
Blood Flow ◽  
Diabetic Retinopathy ◽  
Fatty Acid ◽  
Proliferative Diabetic Retinopathy ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Fatty Acid Binding ◽  
High Positive Correlation ◽  
Blood Biochemical

AbstractThe fatty acid-binding protein4 (FABP4) and vascular endothelial growth factor A (VEGFA) play key roles in the metabolic and cardiovascular diseases, and proliferative diabetic retinopathy (PDR), respectively. To identify FABP4 in vitreous fluid in PDR, vitreous concentrations of FABP4 (V-FABP4) and VEGFA (V-VEGFA) from PDR (n = 20) and non-PDR (n = 20) patients were determined by Enzyme-Linked ImmunoSorbent Assays. The data, which included height and weight, systemic blood pressures, several blood biochemical parameters and blood flow at the optic nerve head (ONH) by laser speckle flowgraphy (LSFG) were collected. The levels of V-FABP4 and V-VEGFA were significantly higher in PDR patients than in non-PDR patients (P < 0.001) with a high positive correlation (r = 0.72, P < 0.001) between them. The findings were not affected by body mass index values and the presence of vitreous hemorrhaging. Among the clinical parameters, V-FABP4 correlated positively with creatinine and negatively with age and aspartate transaminase (AST) levels, while V-VEGFA correlated positively with fasting plasma glucose and hemoglobin A1c (HbA1c) levels but negatively with AST. Multiple regression analyses indicated that V-VEGFA, or V-FABP4, AST and HbA1c were independent predictors of V-FABP4 or V-VEGFA, respectively. Both were negatively correlated, but more evident in V-FABP4, with the ONH ocular blood flow.

scholarly journals Ocular blood flow values measured by laser speckle flowgraphy correlate with the postmenstrual age of normal neonates

2016 ◽  
Vol 254 (8) ◽  
pp. 1631-1636 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Postmenstrual Age ◽  
Normal Neonates

scholarly journals Reproducibility of Neonate Ocular Circulation Measurements Using Laser Speckle Flowgraphy

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Yuji Katayama ◽  
Tetsushi Arimura ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intraclass Correlation ◽  
Ocular Blood Flow ◽  
Eye Diseases ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ocular Circulation ◽  
Time Index ◽  
Mean Blur Rate ◽  
Normal Sleep

Measuring the ocular blood flow in neonates may clarify the relationships between eye diseases and ocular circulation abnormalities. However, no method for noninvasively measuring ocular circulation in neonates is established. We used laser speckle flowgraphy (LSFG) modified for neonates to measure their ocular circulation and investigated whether this method is reproducible. During their normal sleep, we studied 16 subjects (adjusted age of 34–48 weeks) whose blood flow could be measured three consecutive times. While the subjects slept in the supine position, three mean blur rate (MBR) values of the optic nerve head (ONH) were obtained: the MBR-A (mean of all values), MBR-V (vessel mean), and MBR-T (tissue mean), and nine blood flow pulse waveform parameters in the ONH were examined. We analyzed the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) for each parameter. The COVs of the MBR values were all ≤10%. The ICCs of the MBR values were all >0.8. Good COVs were observed for the blowout score, blowout time, rising rate, falling rate, and acceleration time index. Although the measurement of ocular circulation in the neonates was difficult, our results exhibited reproducibility, suggesting that this method could be used in clinical research.

scholarly journals A Change in Ocular Circulation after Photocoagulation for Retinopathy of Prematurity in a Neonate

2017 ◽  
Vol 8 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Tadashi Matsumoto ◽  
Takashi Itokawa ◽  
Tomoaki Shiba ◽  
Kotaro Hine ◽  
Yuichi Hori
Keyword(s):  
Optic Nerve ◽  
Retinopathy Of Prematurity ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Ocular Circulation ◽  
Before And After ◽  
Photocoagulation Treatment ◽  
The Mean ◽  
The Right

Background: The dilation of veins and tortuosity of arteries that occur in retinopathy of prematurity (ROP) are improved by therapy, and thus posttherapy changes in ocular circulation are also conceivable. We report a case of ROP in which we were able to measure the ocular circulation before and after photocoagulation therapy, using a laser speckle flowgraphy (LSFG) system that is modified for neonates. Case Report: A female infant was born at 25 weeks’ gestation with a birth weight of 808 g. We performed photocoagulation in both eyes at age 15 weeks, and we measured the ocular circulation with the “LSFG-baby” system before and at 12 weeks after the photocoagulation treatment. We also measured the mean blur rate (MBR) in the optic nerve head (ONH) and the relative flow volume (RFV) in the retinal vessels, and we examined the change rates from before to after treatment. The changing rate of the MBR-A (the mean of all values) in the ONH in the right and left eyes was 76.5 and 98.5%, respectively. The vascular RFV in the severe dilation and tortuosity quadrant also tended to decrease. Conclusions: Photocoagulation improved the dilation of veins and tortuosity of arteries and reduced the ocular blood flow in this neonate with ROP. The LSFG-baby system effectively and directly revealed the optic nerve and retinal blood vessels.

scholarly journals Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy

PLoS ONE ◽  
2016 ◽  
Vol 11 (12) ◽  
pp. e0168190 ◽  
Author(s):  
Nikolaus Luft ◽  
Piotr A. Wozniak ◽  
Gerold C. Aschinger ◽  
Klemens Fondi ◽  
Ahmed M. Bata ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Flow Measurements ◽  
Blood Flow Measurements

The Influence of Posture Change on Ocular Blood Flow in Normal Subjects, Measured by Laser Speckle Flowgraphy

2013 ◽  
Vol 38 (6) ◽  
pp. 691-698 ◽  
Author(s):  
Yukihiro Shiga ◽  
Masahiko Shimura ◽  
Toshifumi Asano ◽  
Satoru Tsuda ◽  
Yu Yokoyama ◽  
...  
Keyword(s):  
Blood Flow ◽  
Normal Subjects ◽  
Ocular Blood Flow ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Posture Change

scholarly journals Decrease in choroidal blood flow after half and one-third dose verteporfin photodynamic therapy for chronic central serous chorioretinopathy

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Shun Kumashiro ◽  
Seiji Takagi ◽  
Takashi Itokawa ◽  
Akiko Tajima ◽  
Tatsuhiko Kobayashi ◽  
...  
Keyword(s):  
Blood Flow ◽  
Photodynamic Therapy ◽  
Central Serous Chorioretinopathy ◽  
Serous Retinal Detachment ◽  
Rate Of Change ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Choroidal Blood Flow ◽  
Chronic Central Serous Chorioretinopathy

Abstract Background The effect of various reduced doses of verteporfin photodynamic therapy (PDT) on choroidal blood flow in chronic central serous chorioretinopathy (CSC) remains unclear. Therefore, this study aimed to evaluate choroidal blood flow after half-dose PDT (1/2PDT) and one-third dose PDT (1/3PDT) with verteporfin for chronic CSC using laser speckle flowgraphy and spectral-domain optical coherence tomography. Methods Twenty-seven eyes of 27 patients with serous retinal detachment (SRD) caused by chronic CSC for more than 6 months were included in this study. Patients were divided into the 1/2PDT (n = 12; January 2018 to July 2019) and 1/3PDT (n = 15; August 2016 to December 2017) groups based on the treatment period. The best-corrected visual acuity (BCVA), central retinal thickness (CRT), central choroidal thickness (CCT), and mean blur rate in the macular area (m-MBR) and optic nerve head (ONH-MBR) were obtained using laser speckle flowgraphy and evaluated at baseline (pre-treatment), and 2 weeks, 1 month, 3 months, and 6 months after treatment. Results We found that SRD disappeared after 1 month in 92 and 93% of patients’ eyes in the 1/2PDT and 1/3PDT groups, respectively. Recurrence of SRD was observed in one eye at the 6-month follow-up after 1/2PDT and two eyes at the 3-month follow-up after 1/3PDT. No significant improvement was observed in baseline BCVA in the 1/3PDT and 1/2PDT groups. The average m-MBR against baseline significantly decreased at 2 weeks and 1, 3, and 6 months in the 1/2PDT group. The average m-MBR against baseline decreased significantly only at the 2 weeks follow-up in the 1/3PDT group. The average rate of change in the CCT against baseline decreased significantly throughout for up to 6 months in the 1/2PDT group and for up to 3 months in the 1/3PDT group. No significant fluctuation was observed in the ONH-MBR. Conclusions: Here, PDT significantly affected choroidal blood flow depending on the verteporfin dose in chronic CSC. Trial registration This trial was retrospectively registered (UMIN000026850; Approval date 03/04/2017).

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