Effect of Exogenous Angiotensin-II on Local Blood Flow in Kidneys with Neoplasm: Experiments in the rat

1. Six healthy male subjects received 0.9% (w/v) NaCl (saline) followed by incremental doses of bradykinin (1, 3 and 10 pmol/min), via the left brachial artery. Blood flow and the response of blood flow to lower-body negative pressure were measured in both forearms during infusion of saline and each dose of bradykinin. 2. Bradykinin produced a moderate and dose-dependent increase in blood flow in the infused, but not the non-infused, forearm. Lower-body negative pressure produced an approximately 15–20% reduction in blood flow in both forearms, and this response was unaffected by local infusion of bradykinin. 3. Bradykinin, in contrast to angiotensin II, had no acute effect on peripheral sympathetic responses to lower-body negative pressure. We conclude that, in forearm resistance vessels in man, withdrawal of angiotensin II, rather than accumulation of bradykinin, is likely to account for the attenuation of peripheral sympathetic responses after acute administration of a converting-enzyme inhibitor.

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Measurement of local blood flow of the intestine by hydrogen clearance method; Experimental study

The Japanese Journal of Surgery ◽

10.1007/bf02468717 ◽

1979 ◽

Vol 9 (1) ◽

pp. 63-70 ◽

Cited By ~ 6

Author(s):

Yoshio Mishima ◽

Hiroshi Shigematsu ◽

Yoshiaki Horie ◽

Masanori Satoh

Keyword(s):

Experimental Study ◽

Blood Flow ◽

Local Blood Flow ◽

Hydrogen Clearance Method ◽

Hydrogen Clearance

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Morning sickness is just the side effect of a new tachykinin that the placenta secretes to improve local blood flow

Journal of Molecular Endocrinology ◽

10.1530/jme-17-0274 ◽

2018 ◽

Vol 60 (1) ◽

pp. C1-C2

Author(s):

Phil Lowry

Keyword(s):

Blood Flow ◽

Side Effect ◽

Local Blood Flow ◽

Morning Sickness

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Local blood flow, oxygen tension, and oxygen consumption in the rat spinal cord

Journal of Neurosurgery ◽

10.3171/jns.1983.58.4.0526 ◽

1983 ◽

Vol 58 (4) ◽

pp. 526-530 ◽

Cited By ~ 15

Author(s):

Nariyuki Hayashi ◽

Barth A. Green ◽

Mayra Gonzalez-Carvajal ◽

Joseph Mora ◽

Richard P. Veraa

Keyword(s):

Spinal Cord ◽

Blood Flow ◽

Oxygen Consumption ◽

Oxygen Tension ◽

Tissue Oxygen ◽

Local Blood Flow ◽

Rat Spinal Cord ◽

Spinal Cord Blood Flow ◽

Content Type ◽

Tissue Oxygen Consumption

✓ Using a reliable and reproducible microelectrode technique, consistent simultaneous measurements of local spinal cord blood flow (SCBF), tissue oxygen tension, and tissue oxygen consumption were made at cervical, thoracic, and lumbar levels in the rat spinal cord. These observations showed that the metabolic state is maintained constant along the cord, despite significant variations in vasculature. The physiological and anatomical aspects of these findings are discussed.

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Effect of Ibotenic Acid Stereotactically Injected into Striatum or Hippocampus on Local Blood Flow and Glucose Utilization in Rats

Excitotoxins ◽

10.1007/978-1-4757-0384-9_19 ◽

1983 ◽

pp. 251-255

Author(s):

Ch. Owman ◽

J. Andersson ◽

N. H. Diemer ◽

K. Fuxe

Keyword(s):

Blood Flow ◽

Glucose Utilization ◽

Ibotenic Acid ◽

Local Blood Flow

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Gastrointestinal blood flow and oxygen consumption in awake newborn piglets: effect of feeding

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.1983.245.5.g697 ◽

1983 ◽

Vol 245 (5) ◽

pp. G697-G702 ◽

Cited By ~ 4

Author(s):

P. T. Nowicki ◽

B. S. Stonestreet ◽

N. B. Hansen ◽

A. C. Yao ◽

W. Oh

Keyword(s):

Blood Flow ◽

Cardiac Output ◽

O2 Consumption ◽

Gi Tract ◽

Local Blood Flow ◽

O2 Uptake ◽

O2 Extraction ◽

Gastrointestinal Blood Flow ◽

O2 Delivery ◽

Effect Of Feeding

Regional and total gastrointestinal (GI) blood flow, O2 delivery, and whole-gut O2 extraction and O2 consumption were measured before and 30, 60, and 120 min after feeding in nonanesthetized, awake 2-day-old piglets. Cardiac output and blood flow to kidneys, heart, brain, and liver were also determined. Blood flow was measured using the radiolabeled microsphere technique. In the preprandial condition, total GI blood flow was 106 +/- 9 ml X min-1 X 100 g-1, while O2 extraction was 17.2 +/- 0.9% and O2 consumption was 1.99 +/- 0.19 ml O2 X min-1 X 100 g-1. Thirty minutes after slow gavage feeding with 30 ml/kg artificial pig milk, O2 delivery to the GI tract and O2 extraction rose significantly (P less than 0.05) by 35 +/- 2 and 33 +/- 2%, respectively. The increase in O2 delivery was effected by a significant increase in GI blood flow, which was localized to the mucosal-submucosal layer of the small intestine. O2 uptake by the GI tract increased 72 +/- 4% 30 min after feeding. Cardiac output and blood flow to non-GI organs did not change significantly with feeding, whereas arterial hepatic blood flow decreased significantly 60 and 120 min after feeding. The piglet GI tract thus meets the oxidative demands of digestion and absorption by increasing local blood flow and tissue O2 extraction.

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Stimulation of renal sodium reabsorption by angiotensin II

AJP Renal Physiology ◽

10.1152/ajprenal.1977.232.4.f298 ◽

1977 ◽

Vol 232 (4) ◽

pp. F298-F306 ◽

Cited By ~ 5

Author(s):

M. D. Johnson ◽

R. L. Malvin

Keyword(s):

Blood Flow ◽

Angiotensin Ii ◽

Flow Rate ◽

Sodium Reabsorption ◽

Urinary Flow ◽

Filtration Fraction ◽

Water Diuresis ◽

Urinary Osmolality ◽

Anesthetized Dogs ◽

Renal Sodium Reabsorption

Various parameters of renal function were studied before, during, and after the infusion of physiological increments of angiotensin II directly into one renal artery of anesthetized dogs. During water diuresis and during antidiuresis induced with exogenous antidiuretic hormone (ADH), angiotensin II consistently reduced UNaV, UKV, and CPAH, and increased the filtration fraction in the infused kidney. Urinary osmolality was increased only in the presence of ADH, while during water diuresis angiotensin II had no apparent effect on urinary osmolality or flow rate. During saline diuresis, a mean increment of angiotensin II concentration of 14 pg/ml was sufficient to significantly reduce UNaV and urinary flow rate. Changes in CCr, CPAH, and filtration fraction did not correlate with changes in sodium excretion, and intracortical distribution of blood flow remained unaltered. These data support the hypothesis that normal circulating levels of angiogensin II play a direct renal role in the control of sodium, potassium, and water homeostasis, and that angiotensin II exerts a direct, stimulatory effect on tubular sodium reabsorption independent of changes in GFR, RPF, filtration fraction, or intracortical distribution of blood flow.

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