Relationship between articular cartilage damage and subchondral bone properties and meniscal ossification in the Dunkin Hartley guinea pig model of osteoarthritis

2011 ◽  
Vol 40 (5) ◽  
pp. 391-399 ◽  
Author(s):  
JS Thomsen ◽  
TS Straarup ◽  
CC Danielsen ◽  
H Oxlund ◽  
A Brüel
Keyword(s):  
Articular Cartilage ◽  
Guinea Pig ◽  
Subchondral Bone ◽  
Cartilage Damage ◽  
Pig Model ◽  
Articular Cartilage Damage ◽  
Bone Properties ◽  
Guinea Pig Model

scholarly journals Intra-Articular Injections of Curcumin Monoglucuronide TBP1901 Suppresses Articular Cartilage Damage and Regulates Subchondral Bone Alteration in an Osteoarthritis Rat Model

Cartilage ◽  
2021 ◽  
pp. 194760352110432
Author(s):  
Akihiro Nakahata ◽  
Akira Ito ◽  
Ryo Nakahara ◽  
Atsuhiro Kishimoto ◽  
Atsushi Imaizumi ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Acute Phase ◽  
Subchondral Bone ◽  
Rat Model ◽  
Saline Solution ◽  
Cartilage Damage ◽  
Chronic Phase ◽  
Synovial Inflammation ◽  
Free Form ◽  
Articular Cartilage Damage

Objective Curcumin monoglucuronide (TBP1901) is highly water soluble and can convert to free form curcumin, which has pharmacological effects, on intravenous administration. This study aimed to investigate the effectiveness of TBP1901 intra-articular injections in an osteoarthritis (OA) rat model. Methods Sixty-four male Wistar rats (12 weeks old) who underwent destabilized medial meniscus (DMM) surgery were randomly separated into the TBP1901 injection or saline solution (control) injection group. They were sacrificed at 1, 2, 6, or 10 weeks postoperatively (weeks 1, 2, 6, and 10; n = 8 for each group). TBP1901 (30 mg/mL) or saline solution of 50 μL was injected into the knee joints twice a week during weeks 1 and 2 to investigate the effects in the acute phase of posttraumatic (PT) OA or once a week during weeks 6 and 10 to investigate it in the chronic phase of PTOA. Histology, immunohistochemistry, and micro-computed tomography were performed to evaluate the changes in OA. Results TBP1901 injections significantly reduced synovial inflammation at weeks 1 and 2, and tumor necrosis factor-α expression in the articular cartilage at week 6. The TBP1901 injections also significantly suppressed articular cartilage damage, subchondral bone (SB) plate thickening, SB plate perforation, and osteophyte formation at week 10. Conclusions TBP1901 intra-articular injections suppressed synovial inflammation in the acute phase of PTOA in DMM rats. In the chronic phase, TBP1901 suppresses articular cartilage damage and regulates SB plate changes.

In vivo activity of pyrimidine-dispirotripiperaziniumin in the male guinea pig model of genital herpes

2020 ◽  
Vol 09 (01) ◽  
Author(s):  
Novoselova EA ◽  
Alimbarova LM ◽  
Monakhova NS ◽  
Lepioshkin AY ◽  
Ekins S ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Genital Herpes ◽  
Pig Model ◽  
Guinea Pig Model
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