IgG Heavy Chain (Gm) Allotypes in Rheumatoid Arthritis and in Healthy Individuals Seropositive for IgM-Rheumatoid Factor

1985 ◽  
Vol 14 (2) ◽  
pp. 144-148 ◽  
Author(s):  
J. T. Gran ◽  
P. I. Gaarder ◽  
G. Husby ◽  
E. Thorsby
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Heavy Chain ◽  
Healthy Individuals ◽  
Igm Rheumatoid Factor ◽  
Gm Allotypes

scholarly journals A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 ◽  
Vol 155 (6) ◽  
pp. 1690-1701 ◽  
Author(s):  
L Hang ◽  
A N Theofilopoulos ◽  
F J Dixon
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Joint Inflammation ◽  
Close Correlation ◽  
Human Rheumatoid Arthritis ◽  
Igm Rheumatoid Factor ◽  
Joint Pathology ◽  
Old Females

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.

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