Enhancement of Human T Lymphocyte Function by Prothymosin α: Incremed Production of Interleukin-2 and Expression of Interleukin-2 Receptors in Normal Human Peripheral Blood t Lymphocytes

1990 ◽  
Vol 12 (4) ◽  
pp. 595-617 ◽  
Author(s):  
Constantin N. Baxevanis ◽  
Stathis Frillingos ◽  
Konstantin Seferiadis ◽  
George J. Reclos ◽  
Paula Arsenis ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
T Lymphocyte ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Interleukin 2 ◽  
Lymphocyte Function ◽  
Prothymosin Α ◽  
Human T Lymphocyte ◽  
Normal Human ◽  
Normal Human Peripheral Blood

Ferritin in normal human peripheral blood T-lymphocyte subpopulations

1984 ◽  
Vol 86 (1) ◽  
pp. 255-260 ◽  
Author(s):  
X. López-Karpovitch ◽  
M.R. Padrós-Semorile ◽  
X. Alvarez-Hernández
Keyword(s):  
T Lymphocyte ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Lymphocyte Subpopulations ◽  
T Lymphocyte Subpopulations ◽  
Normal Human ◽  
Normal Human Peripheral Blood

scholarly journals Identification of Fas-L-Expressing Apoptotic T Lymphocytes in Normal Human Peripheral Blood

2001 ◽  
Vol 158 (2) ◽  
pp. 387-391 ◽  
Author(s):  
Giuseppe De Panfilis ◽  
Arnaldo Caruso ◽  
Paolo Sansoni ◽  
Giorgio Pasolini ◽  
Diego Semenza ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Normal Human ◽  
Normal Human Peripheral Blood ◽  
Fas L

scholarly journals Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens.

1986 ◽  
Vol 164 (1) ◽  
pp. 339-344 ◽  
Author(s):  
L L Lanier ◽  
J J Ruitenberg ◽  
J H Phillips
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Cytotoxic T Cells ◽  
Low Frequency ◽  
Normal Peripheral Blood ◽  
Normal Human ◽  
Normal Human Peripheral Blood

CD3+ T lymphocytes expressing neither CD4 nor CD8 antigens exist in normal human peripheral blood in low frequency (approximately 3% of lymphocytes). The CD3+,4-,8- phenotype was stably maintained after in vitro culture in IL-2. Culture of CD3+,4-,8- cells in only rIL-2 generated cytotoxic T cells that lysed NK-sensitive and NK-insensitive tumor cell targets without MHC restriction. These experiments clearly show that phenotypically and functionally competent T cells expressing neither CD4 nor CD8 are present in normal peripheral blood.

scholarly journals Identification of normal human peripheral blood monocytes and liver as sites of synthesis of coagulation factor XIII a-chain

Blood ◽  
1987 ◽  
Vol 70 (2) ◽  
pp. 579-582
Author(s):  
LJ Weisberg ◽  
DT Shiu ◽  
PR Conkling ◽  
MA Shuman
Keyword(s):  
Peripheral Blood ◽  
Factor Xiii ◽  
Human Peripheral Blood ◽  
Cdna Probe ◽  
Coagulation Factor ◽  
Blood Monocytes ◽  
Peripheral Blood Monocytes ◽  
Normal Human ◽  
Normal Human Peripheral Blood ◽  
A Chain

Factor XIII is the fibrin-stabilizing factor that covalently cross- links fibrin monomers to form a highly organized, stable fibrin clot. The plasma form of factor XIII is a heterodimer, a2b2, consisting of two a-chains and two b-chains; the intracellular form, such as in platelets and placenta, is a dimer, a2, consisting of a-chains only. The catalytic function of factor XIII, a transglutaminase, resides in the a-chain. To address questions regarding sites of synthesis of factor XIII a-chain, an EcoRI restriction fragment from the protein- coding region of the factor XIII a-chain cDNA was used as a probe for Northern blot analysis. The cDNA probe showed hybridization with a single approximately 4.0-kilobase (kb) message in poly (A)+ mRNA prepared from normal human peripheral blood monocytes and normal human liver. The results demonstrate conclusively that factor XIII a-chains are actively synthesized in circulating monocytes and in liver. To our knowledge, these data represent the first demonstration of synthesis of any blood coagulation factor in primary uncultured and unstimulated monocytes or macrophage cells.

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