The Role of Anti-tubercular Therapy in Patients with Presumed Ocular Tuberculosis

2015 ◽  
Vol 23 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Rupesh Agrawal ◽  
Bhaskar Gupta ◽  
Julio J. Gonzalez-Lopez ◽  
Farzana Rahman ◽  
Sumita Phatak ◽  
...  
Keyword(s):  
Ocular Tuberculosis ◽  
Anti Tubercular Therapy ◽  
Presumed Ocular Tuberculosis

Singapore Ocular Tuberculosis Immunity Study (SPOTIS): Role of T-lymphocyte Profiling in Patients with Presumed Ocular Tuberculosis

2020 ◽  
pp. 1-7 ◽  
Author(s):  
Paul E. Hutchinson ◽  
Ae Ra Kee ◽  
Rupesh Agrawal ◽  
Nobuyo Yawata ◽  
Mayjane Jg Tumulak ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Ocular Tuberculosis ◽  
Presumed Ocular Tuberculosis

Role of routine nephrectomy for non-functioning kidneys due to genitourinary tuberculosis: Data from an Indian subcontinent

2021 ◽  
pp. 205141582098766
Author(s):  
Pradeep Prakash ◽  
Prabhjot Singh ◽  
Amlesh Seth ◽  
Rishi Nayyar ◽  
Brusabhanu Nayak
Keyword(s):  
Indian Subcontinent ◽  
Disease Recurrence ◽  
Drug Resistant ◽  
Second Line ◽  
Sensitivity Testing ◽  
Level Of Evidence ◽  
Lower Blood ◽  
Anti Tubercular Therapy ◽  
Open Nephrectomy

Objective: To evaluate the role of routine nephrectomy for tuberculous non-functioning kidney (TNFK) after receiving anti-tubercular therapy (ATT) by demonstrating whether live tubercle bacilli persist in nephrectomy specimens after treatment or not. Materials and methods: Patients with TNFK who underwent nephrectomy after completion of at least 6 months of ATT were included in this prospective cohort study. We sent tissue/pus from a nephrectomy specimen for acid-fast bacilli (AFB) staining, polymerase chain reaction (PCR) and culture to look for live bacilli. Bacilli were considered alive only if AFB culture was positive. Results: Twenty-four patients underwent nephrectomy for TNFK between April 2015 and October 2017 (18 laparoscopic and 6 open nephrectomy). Laparoscopic nephrectomy was associated with lower blood loss (225 ml versus 408 ml, p = 0.0003) and shorter hospital stay (3 versus 3.8 days, p = 0.06) compared with open nephrectomy; however, mean operative time and overall complications were similar. Eight specimens were AFB smear and/or tuberculosis PCR positive, out of which three showed viable bacilli upon culture. Drug sensitivity testing showed multi-drug resistant strain in all three patients who were treated with second-line ATT. Conclusion: It is preferable to do routine nephrectomy for TNFKs as they are more likely to harbour live bacilli and lead to disease recurrence. Viability testing for AFB must be performed on all operated specimens to identify drug resistant bacilli so that patients may be treated with second-line therapy if required. Level of evidence: 4.

scholarly journals Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review

2021 ◽  
Vol 6 (1) ◽  
pp. e000663
Author(s):  
Samra Rahman ◽  
Muhammad Irfan ◽  
M A Rehman Siddiqui
Keyword(s):  
Interferon Gamma ◽  
Interferon Gamma Release Assay ◽  
Limited Evidence ◽  
Ocular Tuberculosis ◽  
Diagnosis And Management ◽  
Pubmed Database ◽  
Interferon Gamma Release Assays ◽  
Infectious Uveitis ◽  
Release Assay

Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.

scholarly journals Serpiginoid choroiditis associated with presumed ocular tuberculosis

2019 ◽  
Vol 9 (2) ◽  
pp. 127 ◽  
Author(s):  
De-Kuang Hwang ◽  
Te-An Wang ◽  
Kang-Jung Lo ◽  
Shih-Jen Chen
Keyword(s):  
Ocular Tuberculosis ◽  
Presumed Ocular Tuberculosis

scholarly journals A case series of symptomatic ocular tuberculosis and the response to anti-tubercular therapy

2010 ◽  
Vol 55 (1) ◽  
pp. 16 ◽  
Author(s):  
BMGD Yasaratne ◽  
D Madegedara ◽  
NS Senanayake ◽  
T Senaratne
Keyword(s):  
Case Series ◽  
Ocular Tuberculosis ◽  
Anti Tubercular Therapy

Management of ocular tuberculosis(OTB): The role of CT and Positron Emission Tomography(PET) imaging

2021 ◽  
Author(s):  
Kavina Manalan ◽  
Ilaria Testi ◽  
Bhavini Dixit ◽  
Yorissa Payadachee ◽  
Charanjit Sethi ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Emission Tomography ◽  
Ocular Tuberculosis ◽  
Positron Emission

scholarly journals P10 The role of fdg-pet ct imaging in ocular tuberculosis

2017 ◽  
Author(s):  
CS Sethi ◽  
M Bhalla ◽  
MR Stanford ◽  
L Martin ◽  
G Russell ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Ocular Tuberculosis ◽  
Pet Ct ◽  
Fdg Pet Ct

scholarly journals Feasibility of surgical management in patients with mammary tuberculosis-study of 100 cases.

2018 ◽  
Vol 27 (1) ◽  
pp. 44-49
Author(s):  
RN Laila ◽  
B Islam ◽  
S Banu ◽  
J Raihan
Keyword(s):  
Surgical Intervention ◽  
Treatment Strategies ◽  
Diagnosis And Treatment ◽  
Idiopathic Granulomatous Mastitis ◽  
Breast Tuberculosis ◽  
Chest Disease ◽  
Disease Hospital ◽  
Anti Tubercular Therapy

Tuberculous mastitis is a rare entity in patients with mammary disease even in countries where incidence of tuberculosis is high. In Bangladesh, TB is an endemic disease but breast tuberculosis is rarely reported. Its clinical patterns and treatment strategies are changing day by day. With this study, we aimed to analyze the role of surgery in diagnosis and treatment of hundred (100) cases received care for tuberculous mastitis at the Chest Disease Hospital, Rajshahi, from July’ 2012 to July’ 2016. This is a prospective nonrandomized descriptive study. Diagnosis was made in all patients initially by cytological examination from suspected lesions, which revealed typical tuberculous lesions. In all the patients the diagnosis was confirmed by biopsy of the lesion (open biopsy or core cut biopsy) with histological examination and detection of acid fast bacilli in discharge by Gene x-pert test and Z-N staining to exclude idiopathic granulomatous mastitis, malignancy and very rare concomitant malignancy. Medical therapy with anti-tubercular drugs (ATT) ranging from 9 to 12 months with follow up monthly was the mainstay of treatment. Surgical intervention reserved for selected refractory cases (36%). Extension of anti-tubercular therapy from 9 to 12 or 18 months required in fifty-eight(58) patients on the basis of slow clinical response. Complete resolution obtained in 92 patients but residual tiny mass in eight patients confirmed by repeated FNAC or biopsy to be fibrotic. Surgery play an essential role both in diagnosis and treatment of tubercular mastitis in addition with ATT but beware about unnecessary surgical intervention as majority of patients cured with only ATT.TAJ 2014; 27(1): 44-49

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