Reactive oxygen species (ROS) reduce the expression of BRAK/CXCL14 in human head and neck squamous cell carcinoma cells

2010 ◽  
Vol 44 (8) ◽  
pp. 913-924 ◽  
Author(s):  
Yojiro Maehata ◽  
Shigeyuki Ozawa ◽  
Kyo Kobayashi ◽  
Yasumasa Kato ◽  
Fumihiko Yoshino ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Human Head ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species

scholarly journals Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells

2004 ◽  
Vol 24 (22) ◽  
pp. 9695-9704 ◽  
Author(s):  
Andrew Fribley ◽  
Qinghua Zeng ◽  
Cun-Yu Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species

ABSTRACT PS-341, also known as Velcade or Bortezomib, represents a new class of anticancer drugs which has been shown to potently inhibit the growth and/or progression of human cancers, including head and neck squamous cell carcinoma (HNSCC). Although it has been logically hypothesized that NF-κB is a major target of PS-341, the underlying mechanism by which PS-341 inhibits tumor cell growth is unclear. Here we found that PS-341 potently activated the caspase cascade and induced apoptosis in human HNSCC cell lines. Although PS-341 could inhibit NF-κB activation, the inhibition of NF-κB was not sufficient to initiate apoptosis in HNSCC cells. Using biochemical and microarray approaches, we found that proteasome inhibition by PS-341 induced endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in HNSCC cells. The inhibition of ROS significantly suppressed caspase activation and apoptosis induced by PS-341. Consistently, PS-341 could not induce the ER stress-ROS in PS-341-resistant HNSCC cells. Taken together, our results suggest that in addition to the abolishment of the prosurvival NF-κB, PS-341 might directly induce apoptosis by activating proapoptotic ER stress-ROS signaling cascades in HNSCC cells, providing novel insights into the PS-341-mediated antitumor activity.

scholarly journals ATM kinase is a master switch for the ΔNp63α phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage

Cell Cycle ◽  
2008 ◽  
Vol 7 (18) ◽  
pp. 2846-2855 ◽  
Author(s):  
Yiping Huang ◽  
Tanusree Sen ◽  
Jatin Nagpal ◽  
Sunil Upadhyay ◽  
Barry Trink ◽  
...  
Keyword(s):  
Dna Damage ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Human Head ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Atm Kinase
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